Patents by Inventor Olga Marianna Mathe

Olga Marianna Mathe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of trans 4-amino-cyclohexyl acetic acid ethyl ester HCl
    Patent number: 8802888
    Abstract: The invention relates to a process for the preparation of trans 4-amino-cyclohexil ethyl acetate HCl wherein d) hydrogenating 4-nitrophenyl acetic acid in a protic solvent at a temperature between 40-50° C. in the presence of Pd/C under 0.1-0.6 bar overpressure, and e) further hydrogenating the 4-aminophenyl acetic acid obtained in situ in step a) at a temperature between 50-60° C. under 1-4 bar overpressures, then f) heating to reflux the 4-aminocyclohexil acetic acid obtained in step b) for 1-3 hours in hydrochloric ethanol, and if desired after removing the solvent acetonitrile was added to the residue obtained and distilled off.
    Type: Grant
    Filed: December 17, 2009
    Date of Patent: August 12, 2014
    Assignee: Richter Gedeon Nyrt.
    Inventors: Laszlo Hegedus, Laszlo Czibula, Balint Juhasz, Judit Nagyne Bagdy, Denes Markos, Olga Marianna Mathe, Julia Mathe
  • PROCESS FOR THE PREPARATION OF TRANS 4-AMINO-CYCLOHEXYL ACETIC ACID ETHYL ESTER HCL
    Publication number: 20110288329
    Abstract: The invention relates to a process for the preparation of trans 4-amino-cyclohexil ethyl acetate HCl wherein d) hydrogenating 4-nitrophenyl acetic acid in a protic solvent at a temperature between 40-50° C. in the presence of Pd/C under 0.1-0.6 bar overpressure, and e) further hydrogenating the 4-aminophenyl acetic acid obtained in situ in step a) at a temperature between 50-60° C. under 1-4 bar overpressures, then f) heating to reflux the 4-aminocyclohexil acetic acid obtained in step b) for 1-3 hours in hydrochloric ethanol, and if desired after removing the solvent acetonitrile was added to the residue obtained and distilled off.
    Type: Application
    Filed: December 17, 2009
    Publication date: November 24, 2011
    Inventors: Tibor Bence Mathe, Olga Marianna Mathe, Julia Mathe Heiress, Laszlo Hegedus, Laszlo Czibula, Balint Juhasz, Judit Nagyne Bagdy, Denes Markos