Patents by Inventor Olga V. Lapina

Olga V. Lapina has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SALTS AND POLYMORPHS OF CERTAIN MCL-1 INHIBITORS
    Publication number: 20230357274
    Abstract: The present disclosure relates salts and the crystalline forms of certain 3?,4,4?,5-tetrahydro-2H,2?H-spiro[benzo[b][1,4]oxazepine-3,1?-naphthalene] derivatives as well as pharmaceutical formulations and therapeutic uses thereof. The present disclosure also relates to preparing such salts, crystalline forms and pharmaceutical formulations.
    Type: Application
    Filed: May 3, 2023
    Publication date: November 9, 2023
    Inventors: John Enquist, Michael A. Ischay, Olga V. Lapina, David W. Lin, Christopher S. Regens, David A. Siler, Eric A. Standley, Sarah E. Wortman
  • SOLID FORMS OF FXR AGONISTS
    Publication number: 20230190721
    Abstract: Disclosed herein are novel solid forms of FXR agonists. The disclosure also relates to pharmaceutical compositions containing one or more of the solid forms disclosed herein, as well as methods of using the solid forms in the treatment of conditions mediated by FXR. The disclosure also relates to methods for obtaining such solid forms.
    Type: Application
    Filed: October 31, 2022
    Publication date: June 22, 2023
    Inventors: Derek M. Dalton, Peter C. Fung, Nolan Griggs, Jeffrey N. Hemenway, Olga V. Lapina, Matthew M. Logan, Sean T. Neville, Bryan J. Reynolds, Hui-Wen Shih, Anna M. Wagner
  • Solid forms of FXR agonists
    Patent number: 11524005
    Abstract: Disclosed herein are novel solid forms of FXR agonists. The disclosure also relates to pharmaceutical compositions containing one or more of the solid forms disclosed herein, as well as methods of using the solid forms in the treatment of conditions mediated by FXR. The disclosure also relates to methods for obtaining such solid forms.
    Type: Grant
    Filed: February 14, 2020
    Date of Patent: December 13, 2022
    Assignee: Gilead Sciences, Inc.
    Inventors: Derek M. Dalton, Peter C. Fung, Nolan Griggs, Jeffrey N. Hemenway, Olga V. Lapina, Matthew M. Logan, Sean T. Neville, Bryan J. Reynolds, Hui-Wen Shih, Anna M. Wagner
  • SOLID FORMS OF FXR AGONISTS
    Publication number: 20200281911
    Abstract: Disclosed herein are novel solid forms of FXR agonists. The disclosure also relates to pharmaceutical compositions containing one or more of the solid forms disclosed herein, as well as methods of using the solid forms in the treatment of conditions mediated by FXR. The disclosure also relates to methods for obtaining such solid forms.
    Type: Application
    Filed: February 14, 2020
    Publication date: September 10, 2020
    Inventors: Derek M. Dalton, Peter C. Fung, Nolan Griggs, Jeffrey N. Hemenway, Olga V. Lapina, Matthew M. Logan, Sean T. Neville, Bryan J. Reynolds, Hui-Wen Shih, Anna M. Wagner
  • Synthesis of chirally purified substituted benzothiazole diamines
    Patent number: 10179774
    Abstract: Methods for preparing chirally purified substituted 4,5,6,7-tetrahydro-benzothiazole diamines such as, for example, (6R)2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole and purifying a dominant enantiomer of substituted 4,5,6,7-tetrahydro-benzothiazole diamines from entantiomerically enriched mixtures of substituted 4,5,6,7-tetrahydro-benzothiazole diamines are provided herein.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: January 15, 2019
    Assignee: Knopp Biosciences LLC
    Inventors: Prasad Raje, Rajendrakumar Reddy Gadikota, Jian-Xie Chen, Olga V. Lapina, John M. McCall
  • SYNTHESIS OF CHIRALLY PURIFIED SUBSTITUTED BENZOTHIAZOLE DIAMINES
    Publication number: 20170158649
    Abstract: Methods for preparing chirally purified substituted 4,5,6,7-tetrahydro-benzotiazole diamines such as, for example, (6R)2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole and purifying a dominant enantiomer of substituted 4,5,6,7-tetrahydro-benzotiazole diamines from entantiomerically enriched mixtures of substituted 4,5,6,7-tetrahydro-benzotiazole diamines are provided herein.
    Type: Application
    Filed: December 5, 2016
    Publication date: June 8, 2017
    Inventors: Prasad RAJE, Rajendrakumar Reddy GADIKOTA, Jian-Xie CHEN, Olga V. LAPINA, John M. McCALL
  • Solid forms of an ion channel modulator
    Patent number: 9273038
    Abstract: Crystalline solid forms of the selective late sodium current inhibitor 4-(pyrimidin-2-ylmethyl)-7-(4-(trifluoromethoxy)phenyl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the crystalline forms.
    Type: Grant
    Filed: February 12, 2015
    Date of Patent: March 1, 2016
    Assignee: Gilead Sciences, Inc.
    Inventors: Anna Chiu, Olga V. Lapina, Petinka I. Vlahova
  • SOLID FORMS OF AN ION CHANNEL MODULATOR
    Publication number: 20150225383
    Abstract: Crystalline solid forms of the selective late sodium current inhibitor 4-(pyrimidin-2-ylmethyl)-7-(4-(trifluoromethoxy)phenyl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the crystalline forms.
    Type: Application
    Filed: February 12, 2015
    Publication date: August 13, 2015
    Inventors: Anna Chiu, Olga V. Lapina, Petinka I. Vlahova
  • SYNTHESIS OF CHIRALLY PURIFIED SUBSTITUTED BENZOTHIAZOLE DIAMINES
    Publication number: 20140100372
    Abstract: Methods for preparing chirally purified substituted 4,5,6,7-tetrahydro-benzothiazole diamines such as, for example, (6R)2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole and purifying a dominant enantiomer of substituted 4,5,6,7-tetrahydro-benzothiazole diamines from entantiomerically enriched mixtures of substituted 4,5,6,7-tetrahydro-benzothiazole diamines are provided herein.
    Type: Application
    Filed: August 22, 2013
    Publication date: April 10, 2014
    Applicant: KNOPP NEUROSCIENCES, INC.
    Inventors: Prasad RAJE, Rajendrakumar Reddy GADIKOTA, Jian-Xie CHEN, Olga V. LAPINA, John M. McCALL
  • Synthesis of chirally purified substituted benzothiazole diamines
    Patent number: 8519148
    Abstract: Methods for preparing chirally purified substituted 4,5,6,7-tetrahydro-benzothiazole diamines such as, for example, (6R)2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole and purifying a dominant enantiomer of substituted 4,5,6,7-tetrahydro-benzothiazole diamines from entantiomerically enriched mixtures of substituted 4,5,6,7-tetrahydro-benzothiazole diamines are provided herein.
    Type: Grant
    Filed: March 14, 2008
    Date of Patent: August 27, 2013
    Assignee: Knopp Neurosciences, Inc.
    Inventors: Prasad Raje, Rajendrakumar Reddy Gadikota, Jian-Xie Chen, Olga V. Lapina, John M. McCall
  • POLYMORPHS OF HYDROCHLORIDE SALT OF 5-(3-(ETHYLSULFONYL)PHENYL)-3,8-DIMETHYL-N-(1-METHYLPIPERIDIN-4-YL)-9H-PYRIDO[2,3-B]INDOLE-7-CARBOXAMIDE AND METHODS OF USE THEREFOR
    Publication number: 20090270442
    Abstract: Polymorphic forms of the hydrochloride salt of 5-(3-(ethylsulfonyl)phenyl)-3,8-dimethyl-N-(1-methylpiperidin-4-yl)-9h-pyrido[2,3-b]indole-7-carboxamide (referred to herein as Compound 1) which has the formula: and compositions thereof, wherein the Compound 1 is present in one or more polymorphic forms. Also provided are novel methods for the preparation of the polymorphs of Compound 1, and kits and articles of manufacture of the compositions, and methods of using the compositions to treat various diseases.
    Type: Application
    Filed: April 13, 2009
    Publication date: October 29, 2009
    Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Lauren Graham, Paul Isbester, Olga V. Lapina, Bingidimi I. Mobele, Grant J. Palmer, Karl Reineke, Jonathon S. Salsbury, Luckner Ulysse
  • SYNTHESIS OF CHIRALLY PURIFIED SUBSTITUTED BENZOTHIAZOLES
    Publication number: 20080227985
    Abstract: Methods for preparing chirally purified substituted 4,5,6,7-tetrahydro-benzothiazole diamines such as, for example, (6R)2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole and purifying a dominant enantiomer of substituted 4,5,6,7-tetrahydro-benzothiazole diamines from entantiomerically enriched mixtures of substituted 4,5,6,7-tetrahydro-benzothiazole diamines are provided herein.
    Type: Application
    Filed: March 14, 2008
    Publication date: September 18, 2008
    Applicant: KNOPP NEUROSCIENCES, INC.
    Inventors: Prasad Raje, Rajendrakumar Ruddy Gadikota, Jian-Xie Chen, Olga V. Lapina, John M. McCall
  • Stable Elsamitrucin Salts Suitable for Pharmaceutical Formulations
    Publication number: 20070293445
    Abstract: Stable solid, crystalline forms of elsamitrucin salts are provided that are useful in preparing anti-neoplastic parenteral formulations. Also provided are methods for treating neoplastic diseases in humans using parenteral formulations that include at least one stable elsamitrucin salt.
    Type: Application
    Filed: June 15, 2006
    Publication date: December 20, 2007
    Applicant: SPECTRUM PHARMACEUTICALS, INC.
    Inventors: Ashok Gore, Fred Defesche, Hemant Joshi, Guru Reddy, Luigi Lenaz, Paul K. Isbester, Olga V. Lapina, Grant J. Palmer, Jonathon S. Salsbury