Patents by Inventor Olga Y. Zaborina

Olga Y. Zaborina has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phosphorylated Tri-Block Copolymers with Anti-Microbial Properties
    Publication number: 20230285446
    Abstract: The disclosure provides products and methods of treating diseases and disorders involving microbial pathogens, such as intestinal microbial pathogens, e.g., Pseudomonas aeruginosa, by administering an effective amount of a phosphorylated polyethylene glycol compound of defined structural organization. Those diseases and disorders characterized by an epithelium attacked by a microbial pathogen are contemplated, including gastrointestinal infections and inflammation, e.g., treatment of intestinal or esophageal anastomosis or treatment or suppression of anastomotic leakage.
    Type: Application
    Filed: January 18, 2023
    Publication date: September 14, 2023
    Applicants: The University of Chicago, UChicago Argonne, LLC
    Inventors: John C. Alverdy, Matthew Tirrell, Olga Y. Zaborina, Jun Mao, Wei Chen
  • Phosphorylated tri-block copolymers with antimicrobial properties
    Patent number: 11571443
    Abstract: The disclosure provides products and methods of treating diseases and disorders involving microbial pathogens, such as intestinal microbial pathogens, e.g., Pseudomonas aeruginosa, by administering an effective amount of a phosphorylated polyethylene glycol compound of defined structural organization. Those diseases and disorders characterized by an epithelium attacked by a microbial pathogen are contemplated, including gastrointestinal infections and inflammation, e.g., treatment of intestinal or esophageal anastomosis or treatment or suppression of anastomotic leakage.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: February 7, 2023
    Assignee: The University of Chicago
    Inventors: John C. Alverdy, Matthew Tirrell, Olga Y. Zaborina, Jun Mao, Wei Chen
  • MATERIALS AND METHODS OF USING AN INHIBITOR OF PLASMINOGEN ACTIVATION TO TREAT ANASTOMOTIC LEAK
    Publication number: 20210252040
    Abstract: Disclosed herein is the de novo synthesis of phosphorylated polyethylene glycol compounds with three defined ABA (hydrophilic/-phobic/-philic) structures: ABA-PEG10k-Pi10, ABA-PEG16k-Pi14, and ABA-PEG20k-Pi20 and linear polymer PEG20k-Pi20 absent of hydrophobic block. The disclosure also provides materials and methods for treating or reducing the risk or likelihood of developing, anastomotic leak or other microbe-mediated disorders by administering a therapeutically effective amount of a plasminogen inhibitor such as tranexamic acid and/or a phosphate-loaded polymer.
    Type: Application
    Filed: April 23, 2019
    Publication date: August 19, 2021
    Applicants: THE UNIVERSITY OF CHICAGO, RUSH UNIVERSITY MEDICAL CENTER
    Inventors: John C. ALVERDY, Olga Y. ZABORINA, Richard A. JACOBSON
  • PHOSPHORYLATED TRI-BLOCK COPOLYMERS WITH ANTI-MICROBIAL PROPERTIES
    Publication number: 20190247423
    Abstract: The disclosure provides products and methods of treating diseases and disorders involving microbial pathogens, such as intestinal microbial pathogens, e.g., Pseudomonas aeruginosa, by administering an effective amount of a phosphorylated polyethylene glycol compound of defined structural organization. Those diseases and disorders characterized by an epithelium attacked by a microbial pathogen are contemplated, including gastrointestinal infections and inflammation, e.g., treatment of intestinal or esophageal anastomosis or treatment or suppression of anastomotic leakage.
    Type: Application
    Filed: September 29, 2017
    Publication date: August 15, 2019
    Inventors: John C. Alverdy, Matthew Tirrell, Olga Y. Zaborina, Jun Mao, Wei Chen