Patents by Inventor Olga Zelenaia

Olga Zelenaia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vectors comprising stuffer/filler polynucleotide sequences and methods of use
    Patent number: 11427835
    Abstract: Recombinant viral vectors such as AAV vectors designed with expression cassettes that approach the natural packaging capacity of the virus, such as AAV are provided. The recombinant viral vectors reduce residual plasmid DNA impurities.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: August 30, 2022
    Assignee: The Children's Hospital of Philadelphia
    Inventors: J. Fraser Wright, Olga Zelenaia
  • AAV8 vector with enhanced functional activity and methods of use thereof
    Patent number: 10392632
    Abstract: This application relates to the fields of gene therapy and molecular biology. In accordance with the present invention, an adeno-associated virus (AAV) vector comprising an altered capsid protein is provided. More specifically, this invention provides adeno-associated viral vectors comprising protein capsid variants which accelerate vector breakdown and clearance, thereby reducing undesirable immune responses.
    Type: Grant
    Filed: February 14, 2012
    Date of Patent: August 27, 2019
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: John Fraser Wright, Olga Zelenaia, Bernd Hauck, Federico Mingozzi, Katherine A. High
  • VECTORS COMPRISING STUFFER/FILLER POLYNUCLEOTIDE SEQUENCES AND METHODS OF USE
    Publication number: 20160032319
    Abstract: Recombinant viral vectors such as AAV vectors designed with expression cassettes that approach the natural packaging capacity of the virus, such as AAV are provided. The recombinant viral vectors reduce residual plasmid DNA impurities.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 4, 2016
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: J. Fraser WRIGHT, Olga ZELENAIA
  • AAV8 Vector with Enhanced Functional Activity and Methods of Use Thereof
    Publication number: 20140037585
    Abstract: Improved compositions and methods for AAV mediated gene therapy are disclosed.
    Type: Application
    Filed: February 14, 2012
    Publication date: February 6, 2014
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: John Fraser Wright, Olga Zelenaia, Bernd Hauck, Federico Mingozzi, Katherine A. High