Abstract: A method of preparing a vesicular particle having at least in part a lipid and/or polymeric membrane that is a barrier between the interior and exterior of the vesicular particle, wherein the membrane includes at least one inorganic core nanoparticle embedded in the membrane, the method includes the steps of i) providing a first dispersion with one or more inorganic core particles having a hydrophobic dispersant shell, in a solution of membrane forming lipids and/or polymers in a non-aqueous solvent; and ii) introducing the first dispersion into a non-solvent for the membrane forming lipids and/or polymers, wherein the volume of the non-solvent exceeds the volume of the first dispersion, thereby forming the vesicular particles; the produced particle preparations and their uses.