Patents by Inventor Oliver CHRISTOPHE

Oliver CHRISTOPHE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-PROTEIN S SINGLE-DOMAIN ANTIBODIES AND POLYPEPTIDES COMPRISING THEREOF
    Publication number: 20230265211
    Abstract: Vitamin K-dependent Protein S (PS) is a natural anticoagulant acting as a non-enzymatic cofactor for both activated protein C (APC) and tissue factor pathway inhibitor (TFPI). The inventors identify an anti-PS nanobody that very surprisingly enhances the APC-cofactor activity of PS through unknown mechanisms. Very interestingly, this nanobody exerts an antithrombotic effect in injured mesenteric microvessels of mice. As a consequence, it10 constitutes a novel class of antithrombotic agents that could be used for the treatment of acute microthrombosis in pathological states such as sepsis, COVID-19, distal microvascular thrombosis induced by stroke, or sickle-cell disease. Thus, the present invention relates to isolated single-domain antibodies (sdAb) directed against protein S (PS) and polypeptides comprising thereof.
    Type: Application
    Filed: June 28, 2021
    Publication date: August 24, 2023
    Inventors: François SALLER, Cécile DENIS, Delphine BORGEL, Frédéric BORGEL, Oliver CHRISTOPHE, Peter LENTING
  • GOSSYPOL DERIVATIVES, PRODUCTION METHOD THEREOF AND USES OF SAME
    Publication number: 20110046233
    Abstract: The present invention relates to compounds of general formula (1): in which, independently of each other, R1 and R2 represent: —OH, or —CH2—O—R3, or —CH2—S—R3, or R3, R4, R5 and R6 representing, independently of each other, —H or a carbon-containing group with 1 to 10 carbon atoms, saturated or unsaturated, optionally substituted with one or more heteroatomic groups. The invention also relates to pharmaceutical compositions containing these compounds, and their uses, in particular in the context of the treatment of cancer.
    Type: Application
    Filed: November 4, 2010
    Publication date: February 24, 2011
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (I.N.S.E.R.M.)
    Inventors: VI-THUY DAO, Jean De Gunzburg, Robert Michelot, Oliver Christophe De Mil
  • Gossypol derivatives, production method thereof and uses of same
    Patent number: 7851510
    Abstract: The present invention relates to compounds of general formula (1): in which, independently of each other, R1 and R2 represent: —OH, or —CH2—O—R3, or —CH2—S—R3, or R3, R4, R5 and R6 representing, independently of each other, —H or a carbon-containing group with 1 to 10 carbon atoms, saturated or unsaturated, optionally substituted with one or more heteroatomic groups. The invention also relates to pharmaceutical compositions containing these compounds, and their uses, in particular in the context of the treatment of cancer.
    Type: Grant
    Filed: January 6, 2005
    Date of Patent: December 14, 2010
    Assignees: Centre National de la Recherche Scientifique (C.N.R.S.), Institut National de la Sante et de la Recherche Medicale (I.N.S.E.R.M)
    Inventors: Vi-Thuy Dao, Jean De Gunzburg, Robert Michelot, Oliver Christophe De Mil
  • GOSSYPOL DERIVATIVES, PRODUCTION METHOD THEREOF AND USES OF SAME
    Publication number: 20090318566
    Abstract: The present invention relates to compounds of general formula (1): in which, independently of each other, R1 and R2 represent: —OH, or —CH2—O—R3, or —CH2—S—R3, or R3, R4, R5 and R6 representing, independently of each other, —H or a carbon-containing group with 1 to 10 carbon atoms, saturated or unsaturated, optionally substituted with one or more heteroatomic groups. The invention also relates to pharmaceutical compositions containing these compounds, and their uses, in particular in the context of the treatment of cancer.
    Type: Application
    Filed: January 6, 2005
    Publication date: December 24, 2009
    Inventors: Vi-Thuy Dao, Jean De Gunzburg, Robert Michelot, Oliver Christophe De Mil