Patents by Inventor Oliver Cromwell

Oliver Cromwell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA SEQUENCE, AND RECOMBINANT PREPARATION OF GROUP 4 MAJOR ALLERGENS FROM CEREALS
    Publication number: 20130164313
    Abstract: The present invention relates to the provision of DNA sequences of group 4 major allergens from cereals. The invention also encompasses fragments, new combinations of partial sequences and point mutants having a hypoallergenic action. The recombinant DNA molecules and the derived polypeptides, fragments, new combinations of partial sequences and variants can be utilised for the therapy of pollen-allergic diseases. The proteins prepared by recombinant methods can be employed for in vitro and in vivo diagnosis of pollen allergies.
    Type: Application
    Filed: November 16, 2010
    Publication date: June 27, 2013
    Inventors: Andreas NANDY, Helmut Fiebig, Oliver Cromwell
  • DNA sequence, and recombinant preparation of the grass pollen allergen Lol p 4
    Patent number: 8420097
    Abstract: The present invention relates to the provision of a DNA sequence of the major grass pollen allergen Lol p 4. The invention also encompasses fragments, new combinations of partial sequences and point mutants having a hypoallergenic action. The recombinant DNA molecules and the derived polypeptides, fragments, new combinations of partial sequences and variants can be utilized for the therapy of pollen-allergic diseases. The proteins prepared by recombinant methods can be employed for in vitro and in vivo diagnosis of pollen allergies.
    Type: Grant
    Filed: July 9, 2010
    Date of Patent: April 16, 2013
    Assignee: Merck Patent GmbH
    Inventors: Andreas Nandy, Helmut Fiebig, Oliver Cromwell
  • Method for isolating and purifying grass pollen allergens
    Patent number: 8329185
    Abstract: The invention relates to a method for quickly and effectively isolating and purifying five, namely the group 1, 2, 3, 10 and 13 allergens from grass pollen. The purification of said grass pollen is based on the inventive combination of hydrophobic interaction chromatography, gel filtration and cation exchange chromatography. The proteins obtained by the inventive method facilitate an improved diagnosis of pollen allergies and are used in pharmaceutical preparations for the therapy of pollenogenic diseases.
    Type: Grant
    Filed: December 13, 2007
    Date of Patent: December 11, 2012
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Roland Suck, Oliver Cromwell, Helmut Fiebig
  • DNA SEQUENCE AND PREPARATION OF GRASS POLLEN ALLERGEN PHL P4 BY RECOMBINANT METHODS
    Publication number: 20120288526
    Abstract: The present invention relates to the provision of the genetic sequence of the major grass pollen allergen Phl p 4. The invention covers fragments, new combinations of partial sequences and point mutants having a hypoallergenic action. The recombinant DNA molecules and the derived polypeptides, fragments, new combinations of partial sequences and variants can be utilised for the therapy of pollen-allergic diseases. The proteins prepared by recombinant methods can be employed for the in vitro and in vivo diagnosis of pollen allergies.
    Type: Application
    Filed: February 24, 2011
    Publication date: November 15, 2012
    Applicant: Merck Patent GmbH
    Inventors: HELMUT FIEBIG, ANDREAS NANDY, ROLAND SUCK, OLIVER CROMWELL, ARND PETERSEN, WOLF-MEINHARD BECKER
  • VARIANTS OF THE MAJOR ALLERGEN PHL P 1 FROM TIMOTHY GRASS
    Publication number: 20120263741
    Abstract: The invention relates to pharmaceutically important variants of the major allergen Phl p 1 from timothy grass, characterised in that a preparation, hitherto not possible, of monomeric molecules which are soluble and stable in physiological media can be carried out with the aid of prokaryotic expression systems and subsequent purification thereof.
    Type: Application
    Filed: March 22, 2010
    Publication date: October 18, 2012
    Inventors: Roland SUCK, Helmut Fiebig, Oliver Cromwell
  • Variants of group 1 allergens from having reduced allergenicity and maintained T-cell reactivity
    Patent number: 8263090
    Abstract: The present invention relates to the preparation and use of variants of the group 1 allergens of the Poaceae (sweet grasses) which are characterised by reduced IgE reactivity compared with the known wild-type allergens and at the same time by substantially maintained reactivity with T-lymphocytes. These hypoallergenic allergen variants can be employed for the specific immunotherapy (hyposensitisation) of patients having grass pollen allergy or for the preventive immunotherapy of grass pollen allergies.
    Type: Grant
    Filed: July 11, 2005
    Date of Patent: September 11, 2012
    Assignee: Merck Patent GmbH
    Inventors: Helmut Fiebig, Martin Wald, Andreas Nandy, Helga Kahlert, Bernahrd Weber, Oliver Cromwell
  • DNA sequence and recombinant production of the grass pollen allergen Phl p 4
    Patent number: 8128935
    Abstract: The present invention relates to the provision of the genetic sequence of the major grass pollen allergen Phl p 4. The invention also covers fragments, new combinations of partial sequences and point mutants having a hypoallergenic action. The recombinant DNA molecules and the derived polypeptides, fragments, new combinations of partial sequences and variants can be utilised for the therapy of pollen-allergic diseases. The proteins prepared by recombinant methods can be employed for the in vitro and in vivo diagnosis of pollen allergies.
    Type: Grant
    Filed: June 11, 2003
    Date of Patent: March 6, 2012
    Assignee: Merck Patent GmbH
    Inventors: Helmut Fiebig, Andreas Nandy, Roland Suck, Oliver Cromwell, Arnd Petersen, Wolf-Meinhard Becker
  • Insect poison allergens with reduced IgE reactivity and method for producing the same
    Patent number: 8048424
    Abstract: The invention relates to recombinant insect poison allergens and to a specific method for producing them. Said allergens can be varied according to whether they are produced using folds (conformations) that are identical or different to those that occur naturally. The proteins with folds that do not occur naturally have a reduced IgE reactivity or allergenity and can therefore be used as therapeutic agents in the immunotherapy of allergies.
    Type: Grant
    Filed: August 9, 2007
    Date of Patent: November 1, 2011
    Assignee: Merck Patent GmbH
    Inventors: Roland Suck, Oliver Cromwell, Helmut Fiebig
  • DNA SEQUENCE, AND RECOMBINANT PREPARATION OF THE GRASS POLLEN ALLERGEN LOL P4
    Publication number: 20110104209
    Abstract: The present invention relates to the provision of a DNA sequence of the major grass pollen allergen Lol p 4. The invention also encompasses fragments, new combinations of partial sequences and point mutants having a hypoallergenic action. The recombinant DNA molecules and the derived polypeptides, fragments, new combinations of partial sequences and variants can be utilised for the therapy of pollen-allergic diseases. The proteins prepared by recombinant methods can be employed for in vitro and in vivo diagnosis of pollen allergies.
    Type: Application
    Filed: December 6, 2010
    Publication date: May 5, 2011
    Inventors: Andreas NANDY, Helmut Fiebig, Oliver Cromwell
  • DNA sequence, and recombinant preparation of group 4 major allergens from cereals
    Patent number: 7935347
    Abstract: The invention relates to the preparation of DNA sequences of group 4 major allergens from cereals. The invention also includes fragments, novel combinations of partial sequences and point mutations with hypoallergenic effects. The recombinant DNA molecules and the derived polypeptides, fragments, novel combinations of partial sequences and variants can be used for therapy of pollen-allergy diseases. The proteins produced by recombination can be applied to in-vitro and in-vivo diagnosis of pollen allergies.
    Type: Grant
    Filed: December 1, 2004
    Date of Patent: May 3, 2011
    Assignee: Merck Patent GmbH
    Inventors: Andreas Nandy, Helmut Fiebig, Oliver Cromwell
  • DNA SEQUENCE, AND RECOMBINANT PREPARATION OF THE GRASS POLLEN ALLERGEN LOL P 4
    Publication number: 20100310472
    Abstract: The present invention relates to the provision of a DNA sequence of the major grass pollen allergen Lol p 4. The invention also encompasses fragments, new combinations of partial sequences and point mutants having a hypoallergenic action. The recombinant DNA molecules and the derived polypeptides, fragments, new combinations of partial sequences and variants can be utilised for the therapy of pollen-allergic diseases. The proteins prepared by recombinant methods can be employed for in vitro and in vivo diagnosis of pollen allergies.
    Type: Application
    Filed: July 9, 2010
    Publication date: December 9, 2010
    Inventors: Andreas NANDY, Helmut FIEBIG, Oliver CROMWELL
  • DNA sequence, and recombinant preparation of the grass pollen allergen Lol p4
    Patent number: 7846448
    Abstract: The present invention relates to the provision of a DNA sequence of the major grass pollen allergen Lol p 4. The invention also encompasses fragments, new combinations of partial sequences and point mutants having a hypoallergenic action. The recombinant DNA molecules and the derived polypeptides, fragments, new combinations of partial sequences and variants can be utilized for the therapy of pollen-allergic diseases. The proteins prepared by recombinant methods can be employed for in vitro and in vivo diagnosis of pollen allergies.
    Type: Grant
    Filed: December 1, 2004
    Date of Patent: December 7, 2010
    Assignee: Merck Patent GmbH
    Inventors: Andreas Nandy, Helmut Fiebig, Oliver Cromwell
  • Phl p 5a derivatives having reduced allergeneity and retained t-cell reactivity
    Publication number: 20100158955
    Abstract: The present invention relates to the preparation and use of variants of the group 5 allergen of the Pooideae which are characterised by reduced IgE reactivity compared with the known wild-type allergens and at the same time by substantially retained reactivity with T lymphocytes. These hypoallergenic allergen variants can be employed for the specific immunotherapy (hyposensitisation) of patients having grass pollen allergy or for the preventative immunotherapy of grass pollen allergies.
    Type: Application
    Filed: May 6, 2004
    Publication date: June 24, 2010
    Inventors: Martin Wald, Oliver Cromwell, Andreas Nandy, Helga Kahlert, Bernhard Weber, Helmut Fiebig
  • Variants of the major allergen Phl p 1 from timothy grass
    Patent number: 7731970
    Abstract: The invention relates to pharmaceutically important variants of the major allergen Phl p 1 from timothy grass, characterized in that a preparation, hitherto not possible, of monomeric molecules which are soluble and stable in physiological media can be carried out with the aid of prokaryotic expression systems and subsequent purification thereof.
    Type: Grant
    Filed: July 31, 2003
    Date of Patent: June 8, 2010
    Assignee: Merck Patent GmbH
    Inventors: Roland Suck, Helmut Fiebig, Oliver Cromwell
  • PROCESS FOR THE PREPARATION OF HYPOALLERGENIC MAJOR BIRCH POLLEN ALLERGEN rBet v 1
    Publication number: 20090069236
    Abstract: The invention relates to a process for the preparation of hypoallergenic major birch pollen allergens by means of one or more chromatographic purification steps using essentially unbuffered aqueous bases as eluent and subsequent neutralisation. The hypoallergenic major birch pollen allergens are distinguished by a lack of, but at least by reduced immunoglobulin E binding with simultaneous retention of therapeutically relevant T-cell stimulation. They can therefore be employed as low-side-effect therapeutic agents for specific immunotherapy.
    Type: Application
    Filed: July 3, 2008
    Publication date: March 12, 2009
    Inventors: Roland SUCK, Helmut Fiebig, Oliver Cromwell
  • Variants of Group 1 Allergens from Poaceae Having Reduced Allergenicity and Maintained T-Cell Reactivity
    Publication number: 20080267985
    Abstract: The present invention relates to the preparation and use of variants of the group 1 allergens of the Poaceae (sweet grasses) which are characterised by reduced IgE reactivity compared with the known wild-type allergens and at the same time by substantially maintained reactivity with T-lymphocytes. These hypoallergenic allergen variants can be employed for the specific immunotherapy (hyposensitisation) of patients having grass pollen allergy or for the preventive immunotherapy of grass pollen allergies.
    Type: Application
    Filed: July 11, 2005
    Publication date: October 30, 2008
    Applicant: MERCK PATENT GMBH
    Inventors: Helmut Fiebig, Martin Wald, Andreas Nandy, Helga Kahlert, Bernahrd Weber, Oliver Cromwell
  • Method for isolating and purifying grass pollen allergens
    Publication number: 20080118991
    Abstract: The invention relates to a method for quickly and effectively isolating and purifying five, namely the group 1, 2, 3, 10 and 13 allergens from grass pollen. The purification of said grass pollen is based on the inventive combination of hydrophobic interaction chromatography, gel filtration and cation exchange chromatography. The proteins obtained by the inventive method facilitate an improved diagnosis of pollen allergies and are used in pharmaceutical preparations for the therapy of pollenogenic diseases.
    Type: Application
    Filed: December 13, 2007
    Publication date: May 22, 2008
    Inventors: Roland Suck, Oliver Cromwell, Helmut Fiebig
  • Method for isolating and purifying grass pollen allergens
    Publication number: 20080118536
    Abstract: The invention relates to a method for quickly and effectively isolating and purifying five, namely the group 1, 2, 3, 10 and 13 allergens from grass pollen. The purification of said grass pollen is based on the inventive combination of hydrophobic interaction chromatography, gel filtration and cation exchange chromatography. The proteins obtained by the inventive method facilitate an improved diagnosis of pollen allergies and are used in pharmaceutical preparations for the therapy of pollenogenic diseases.
    Type: Application
    Filed: December 13, 2007
    Publication date: May 22, 2008
    Inventors: Roland Suck, Oliver Cromwell, Helmut Fiebig
  • Dna Sequence, and Recombinant Preparation of Group 4 Major Allergens From Cereals
    Publication number: 20080108561
    Abstract: The invention relates to the preparation of DNA sequences of group 4 major allergens from cereals. The invention also includes fragments, novel combinations of partial sequences and point mutations with hypoallergenic effects. The recombinant DNA molecules and the derived polypeptides, fragments, novel combinations of partial sequences and variants can be used for therapy of pollen-allergy diseases. The proteins produced by recombination can be applied to in-vitro and in-vivo diagnosis of pollen allergies.
    Type: Application
    Filed: December 1, 2004
    Publication date: May 8, 2008
    Applicant: MERCK PATENT GMBH
    Inventors: Andreas Nandy, Helmut Fiebig, Oliver Cromwell
  • Method for isolating and purifying grass pollen allergens
    Patent number: 7326769
    Abstract: The invention relates to a method for quickly and effectively isolating and purifying five, namely the group 1, 2, 3, 10 and 13 allergens from grass pollen. The purification of said grass pollen is based on the inventive combination of hydrophobic interaction chromatography, gel filtration and cation exchange chromatography. The proteins obtained by the inventive method facilitate an improved diagnosis of pollen allergies and are used in pharmaceutical preparations for the therapy of pollenogenic diseases.
    Type: Grant
    Filed: August 18, 2000
    Date of Patent: February 5, 2008
    Assignee: Merck Patentgesellschaft Mit Beschrankter Haftung
    Inventors: Roland Suck, Oliver Cromwell, Helmut Fiebig