Patents by Inventor Oliver D. King

Oliver D. King has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Optical phased array controlled RF phased array
    Patent number: 11947043
    Abstract: A system may include an optical phased array, a photodiode array, and a radiofrequency (RF) antenna element array. The optical phased array may be configured to: receive a laser signal from a signal laser; and output an optical beam. Each photodiode may be configured to: receive at least a portion of the optical beam and at least a portion of an optical plane wave beam, wherein the optical plane wave beam is formed based at least on a local oscillator (LO) laser that outputs a laser beam having a different wavelength from the signal laser; and output an electronic signal based on the at least the portion of the optical beam and the at least a portion of the optical plane wave beam. The RF antenna element array may be configured to output an RF beam based on received electronic signals from the photodiode array.
    Type: Grant
    Filed: September 18, 2020
    Date of Patent: April 2, 2024
    Assignee: Rockwell Collins, Inc.
    Inventors: Oliver S. King, Ronald D. Esman
  • METHODS AND COMPOSITIONS FOR TREATMENT OF MUSCLE DISEASE WITH IPSC-INDUCED HUMAN SKELETAL MUSCLE STEM CELLS
    Publication number: 20240018479
    Abstract: Human skeletal muscle stem cells were generated from facioscapulohumeral muscular dystrophy (FSHD) and healthy control iPSC using a transgene-free skeletal muscle differentiation protocol and production of stable iMyoblasts. Analyses revealed that FSHD and healthy control iMyoblasts are embryonic-like myogenic cells that undergo myotube differentiation ex vivo by growth factor depletion and are efficiently transplantable into the tibialis anterior (TA) muscles of NSG mice, where human muscle under-goes embryonic-to-adult myosin isoform switching. The DUX4 FSHD disease gene maintains its hypomethylated disease state inFSHD iPSC and iMyoblast, and its expression is upregulated during myotube differentiation and in muscle xenografts. Consequently, these iMyoblasts accurately exhibit the molecular pathology of human muscular dystrophies and are useful for the development of drug, gene editing and stem cell therapeutics.
    Type: Application
    Filed: October 25, 2021
    Publication date: January 18, 2024
    Inventors: Charles P. Emerson, Dongsheng Guo, Katelyn M. Daman, Jing Yan, Jennifer Chee-Jen Chen, Meng-jiao Shi, Oliver D. King, Lawrence J. Hayward
  • Molecular diagnosis of FSHD by epigenetic signature
    Patent number: 10870886
    Abstract: The present invention includes methods of determining whether an individual in need thereof has, or is at risk of developing, facioscapulohumeral muscular dystrophy (FSHD).
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: December 22, 2020
    Assignee: University of Massachusetts Medical Center
    Inventors: Peter L. Jones, Takako Jones, Johnny Salameh, Colin Quinn, Oliver D. King
  • Molecular Diagnosis of FSHD By Epigenetic Signature
    Publication number: 20170306403
    Abstract: The present invention includes methods of determining whether an individual in need thereof has, or is at risk of developing, facioscapulohumeral muscular dystrophy (FSHD).
    Type: Application
    Filed: October 7, 2015
    Publication date: October 26, 2017
    Inventors: Peter L. Jones, Takako Jones, Johnny Salameh, Colin Quinn, Oliver D. King
  • COMPOSITIONS AND METHODS FOR CHARACTERIZING AND TREATING MUSCULAR DYSTROPHY
    Publication number: 20160160217
    Abstract: Compositions and methods for identifying new treatments for Facioscapulohumeral muscular dystrophy (FSHD), and uses thereof.
    Type: Application
    Filed: February 12, 2016
    Publication date: June 9, 2016
    Inventors: Charles P. Emerson, Jennifer Chen, Oliver D. King
  • Compositions and methods for characterizing and treating muscular dystrophy
    Patent number: 9260755
    Abstract: Compositions and methods for identifying new treatments for Facioscapulohumeral muscular dystrophy (FSHD), and uses thereof.
    Type: Grant
    Filed: April 11, 2013
    Date of Patent: February 16, 2016
    Assignee: University of Massachusetts
    Inventors: Charles P. Emerson, Jr., Jennifer Chen, Oliver D. King
  • Compositions and Methods for Characterizing and Treating Muscular Dystrophy
    Publication number: 20130347136
    Abstract: Compositions and methods for identifying new treatments for Facioscapulohumeral muscular dystrophy (FSHD), and uses thereof.
    Type: Application
    Filed: April 11, 2013
    Publication date: December 26, 2013
    Inventors: Charles P. Emerson, JR., Jennifer Chen, Oliver D. King