Abstract: Provided herein are hierarchical protein structures comprising two or more proteins extending in one or more dimensions, the hierarchical protein structure comprising: a first protein comprising: (i) a patch A comprising one or more polynucleotides conjugated to the surface of the first protein; and (ii) a patch B comprising one or more polynucleotides conjugated to the surface of the first protein; and a second protein comprising: (i) a patch A? comprising one or more polynucleotides conjugated to the surface of the second protein; and (ii) a patch B? comprising one or more polynucleotides conjugated to the surface of the second protein; wherein the one or more polynucleotides of the patch A hybridizes to the one or more polynucleotides of the patch A?, and/or the one or more polynucleotides of the patch B hybridizes to the one or more polynucleotides of the patch B? to form the hierarchical protein structure. Also provided are methods of making the hierarchical protein structures.

Abstract: The present disclosure is generally directed to methods for making protein polymers. The methods comprise utilizing oligonucleotides for controlling the association pathway of oligonucleotide-functionalized proteins into oligomeric/polymeric materials.

Abstract: The present disclosure provides compositions comprising protein crystals and methods for programmable biomaterial synthesis. The methods of the disclosure provide the ability to organize proteins within protein crystals with control over protein orientation.