Patents by Inventor Oliver Kaltenbrunner

Oliver Kaltenbrunner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MITIGATION OF THERAPEUTIC PROTEIN FRAGMENTATION DURING CELL CULTURE HARVEST PROCESSES
    Publication number: 20240262908
    Abstract: Disclosed herein are methods for harvesting a recombinant protein comprising an asparaginyl endopeptidase (AEP) cleavage site, as well as methods for inhibiting cleavage of a recombinant protein comprising an AEP cleavage site, during a biomanufacturing process.
    Type: Application
    Filed: February 1, 2024
    Publication date: August 8, 2024
    Applicant: AMGEN INC.
    Inventors: Gang Xiao, Hyo Seon Chung, Quanzhou Luo, Tamer Eris, Joseph Edward Basconi, Xiaoyang Zhao, Pavel Bondarenko, Krista Marie Petty, Oliver Kaltenbrunner
  • LARGE SCALE BIOREACTOR SYSTEM AND METHOD
    Publication number: 20240076604
    Abstract: A large scale bioreactor system includes a stainless steel large scale bioreactor having at least one valve assembly, and an aseptic connector assembly coupled to the at least one valve assembly of the bioreactor. A perfusion device includes an Alternating Tangential Filtration assembly with an autoclaved valve assembly coupled to the aseptic connector assembly, and the aseptic connector assembly includes one of a triclamp aseptic connector or a hose assembly. Single use feed containers include an aseptic connector assembly.
    Type: Application
    Filed: September 5, 2023
    Publication date: March 7, 2024
    Inventors: Gregory S. Stimpfl, Oliver Kaltenbrunner, Mark O. Brothers, David C. Hogenson, Thomsen P. Sawicky, Min Kyu Choi, Jeffrey T. Ranney, John C. Roseland