Patents by Inventor Oliver Kensch
Oliver Kensch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11806404Abstract: The invention relates to site specific homogeneous binder drug conjugates of kinesin spindle protein inhibitors, to active metabolites of these conjugates, to processes for preparing these conjugates, to the use of these conjugates for the treatment and/or prophylaxis of diseases and to the use of these conjugates for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases. Such treatments can be carried out as monotherapy or else in combination with other medicaments or further therapeutic measures.Type: GrantFiled: February 3, 2021Date of Patent: November 7, 2023Assignee: BAYER PHARMA AKTIENGESELLSCHAFTInventors: Hans-Georg Lerchen, Yolanda Cancho Grande, Beatrix Stelte-Ludwig, Anette Sommer, Christoph Mahlert, Anne-Sophie Rebstock, Simone Greven, Nils Griebenow, Jan Tebbe, Oliver Kensch
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Publication number: 20230212532Abstract: The present invention relates to novel recombinant Bacillus megaterium cytochrome P450-monooxygenase (P450-BM3) variants for the C19 hydroxylation of steroids and derivatives thereof or for improved BM3 protein expression. In particular, the present invention also relates to methods and processes using P450-BM3 variants for the production of estrone and estradiol.Type: ApplicationFiled: February 1, 2021Publication date: July 6, 2023Inventors: Oliver KENSCH, Kai THEDE, Petra HELFRICH, Lilly SKALDEN, Ludwig ZORN, Sabine TRENNER, Jens BURMEISTER, Nils KRETSCHMANN, Florian RICHTER, Wayne COCO, Marcus LUDWIG, Dalia BULUT, Frank BERENDES, Jens PILLING, Jakob WAGNER, Ruben LINNHOFF
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Publication number: 20220220457Abstract: The present invention concerns proteins having improved omega-transaminase (?-TA) activity, nucleic acid molecules encoding respective proteins having improved ?-TA activity and methods for stereo selective synthesis of chiral amines and amino acids or increasing of chiral amines isomers in enantiomer mixtures.Type: ApplicationFiled: July 30, 2019Publication date: July 14, 2022Inventors: Nina BOHLKE, Wayne COCO, Mark James FORD, Saskia FUNK, Ulrike KELLER, Oliver KENSCH, Ksenia NIESEL, Nilkolaus PAWLOWSKI, Moritz SCHON, Cindy SCHULENBURG, Andreas Karl STEIB, Christina THIES
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Publication number: 20210252161Abstract: The invention relates to site specific homogeneous binder drug conjugates of kinesin spindle protein inhibitors, to active metabolites of these conjugates, to processes for preparing these conjugates, to the use of these conjugates for the treatment and/or prophylaxis of diseases and to the use of these conjugates for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases. Such treatments can be carried out as monotherapy or else in combination with other medicaments or further therapeutic measures.Type: ApplicationFiled: February 3, 2021Publication date: August 19, 2021Inventors: Hans-Georg LERCHEN, Yolanda CANCHO GRANDE, Beatrix STELTE-LUDWIG, Anette SOMMER, Christoph MAHLERT, Anne-Sophie REBSTOCK, Simone GREVEN, Nils GRIEBENOW, Jan TEBBE, Oliver KENSCH
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Patent number: 10973923Abstract: The invention relates to site specific homogeneous binder drug conjugates of kinesin spindle protein inhibitors, to active metabolites of these conjugates, to processes for preparing these conjugates, to the use of these conjugates for the treatment and/or prophylaxis of diseases and to the use of these conjugates for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases. Such treatments can be carried out as monotherapy or else in combination with other medicaments or further therapeutic measures.Type: GrantFiled: June 20, 2016Date of Patent: April 13, 2021Assignee: BAYER PHARMA AKTIENGESELLSCHAFTInventors: Hans-Georg Lerchen, Yolanda Cancho Grande, Beatrix Stelte-Ludwig, Anette Sommer, Christoph Mahlert, Anne-Sophie Rebstock, Simone Greven, Nils Griebenow, Jan Tebbe, Oliver Kensch
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Publication number: 20190262463Abstract: The invention relates to site specific homogeneous binder drug conjugates of kinesin spindle protein inhibitors, to active metabolites of these conjugates, to processes for preparing these conjugates, to the use of these conjugates for the treatment and/or prophylaxis of diseases and to the use of these conjugates for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases. Such treatments can be carried out as monotherapy or else in combination with other medicaments or further therapeutic measures.Type: ApplicationFiled: June 20, 2016Publication date: August 29, 2019Applicant: BAYER PHARMA AKTIENGESELLSCHAFTInventors: Hans-Georg LERCHEN, Yolanda CANCHO GRANDE, Beatrix STELTE-LUDWIG, Anette SOMMER, Christoph MAHLERT, Anne-Sophie REBSTOCK, Simone GREVEN, Nils GRIEBENOW, Jan TEBBE, Oliver KENSCH
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Patent number: 9999238Abstract: Provided herein are variants of Buttiauxella sp. phytases that may be used in industrial applications including methods for starch liquefaction, alcohol fermentations and for enhancing phosphate digestion in foods and animal feeds.Type: GrantFiled: June 8, 2017Date of Patent: June 19, 2018Assignee: DANISCO US INCInventors: Oliver Kensch, Klaus Schulze Pellengahr, Birgitta Leuthner, Jayarama K Shetty, Michael J. Pepsin, Soeren Dalsgaard, Mai Faurschou Isaksen
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Publication number: 20180125094Abstract: Provided herein are variants of Buttiauxella sp. phytases that may be used in industrial applications including methods for starch liquefaction, alcohol fermentations and for enhancing phosphate digestion in foods and animal feeds.Type: ApplicationFiled: June 8, 2017Publication date: May 10, 2018Inventors: OLIVER KENSCH, KLAUS SCHULZE PELLENGAHR, BIRGITTA LEUTHNER, JAYARAMA K SHETTY, Michael J. PEPSIN, SOEREN DALSGAARD, MAI FAURSCHOU ISAKSEN
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Publication number: 20170143004Abstract: Provided herein are variants of Buttiauxella sp. phytases that may be used in industrial applications including methods for starch liquefaction, alcohol fermentations and for enhancing phosphate digestion in foods and animal feeds.Type: ApplicationFiled: July 25, 2016Publication date: May 25, 2017Applicant: Danisco US Inc.Inventors: Oliver Kensch, Klaus Schulze Pellengahr, Birgitta Leuthner, Jayarama K. Shetty, Michael Pepsin, Soren Dalsgaard, Mai Faurschou Isaksen
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Patent number: 9273295Abstract: The present invention relates to enzymes and processes. In particular, there is described an isolated polypeptide comprising the amino acid sequence corresponding to Citrobacter freundii phytase or a homologue, a modified form, a functional equivalent or an effective fragment thereof. There is also described a host cell transformed or transfected with a nucleic acid encoding a bacterial phytase enzyme or a modified form as well as the use of such a phytase or modified form in food or animal feed.Type: GrantFiled: September 14, 2011Date of Patent: March 1, 2016Assignee: DUPONT NUTRITION BIOSCIENCES APSInventors: Andrei Miasnikov, Vijay Kumar, Oliver Kensch, Klaus Pellangahr, Birgitta Leuthner, Ulrich Kettling, Andre Koltermann
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Patent number: 9040277Abstract: The present disclosure provides novel mannanase variants which have an amino acid sequence that varies from that of the parent/wild type Trichoderma reesei mannanase, and which have one or more advantageous properties like improved thermo stability; temperature/activity profile; pH/activity profile; specific activity; and pH/protease-sensitivity. The novel mannanase variants are useful and used in alcohol fermentations processes and/or productions, for coffee extraction and the processing of coffee waste, as a supplement to food and feed, for enzyme aided bleaching of paper pulps, as bleaching and/or desizing agent in textile industry, for oil and gas well stimulation by hydraulic fracturing, as detergent, as baking ingredients, for removal of biofilms and in delivery systems, for grain processing or for the processing of renewable resources intended for the production of biological fuels, and in the textile, oil drilling, cleaning, laundering, detergent, and cellulose fiber processing industries.Type: GrantFiled: November 24, 2010Date of Patent: May 26, 2015Assignee: BASF SEInventor: Oliver Kensch
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Publication number: 20140234490Abstract: Provided herein are variants of Buttiauxella sp. phytases that may be used in industrial applications including methods for starch liquefaction, alcohol fermentations and for enhancing phosphate digestion in foods and animal feeds.Type: ApplicationFiled: January 22, 2014Publication date: August 21, 2014Applicant: Danisco US Inc.Inventors: Oliver Kensch, Klaus Schulze Pellengahr, Birgitta Leuthner, Jayarama K. Shetty, Michael Pepsin, Soren Dalsgaard, Mai Faurschou Isaksen
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Patent number: 8673609Abstract: Provided herein are variants of Buttiauxella sp. phytases that may be used in industrial applications including methods for starch liquefaction, alcohol fermentations and for enhancing phosphate digestion in foods and animal feeds.Type: GrantFiled: April 17, 2009Date of Patent: March 18, 2014Assignee: Danisco US Inc.Inventors: Oliver Kensch, Klaus Schulze Pellengahr, Birgitta Leuthner, Jayarama K. Shetty, Michael Pepsin, Søren Dalsgaard, Mai Faurschou Isaksen
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Publication number: 20130136825Abstract: The present invention relates to enzymes and processes. In particular, there is described an isolated polypeptide comprising the amino acid sequence corresponding to Citrobacter freundii phytase or a homologue, a modified form, a functional equivalent or an effective fragment thereof. There is also described a host cell transformed or transfected with a nucleic acid encoding a bacterial phytase enzyme or a modified form as well as the use of such a phytase or modified form in food or animal feed.Type: ApplicationFiled: September 14, 2011Publication date: May 30, 2013Applicant: DUPONT NUTRITION BIOSCIENCES APSInventors: Andrei Miasnikov, Vijay Kumar, Oliver Kensch, Klaus Pellangahr, Birgitta Leuthner, Ulrich Kettling, Andre Koltermann
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Patent number: 8409839Abstract: Provided herein are improved variants of polypeptides having cellobiohydrolase II activity, nucleic acids encoding the polypeptides, vectors, host cells containing the nucleic acids and methods for producing the polypeptides. The polypeptides encompassed by this disclosure may be used in numerous applications including the use of the polypeptides for the production of biofuels and for the synthesis of platform chemicals or biopolymers from renewable sources.Type: GrantFiled: December 9, 2009Date of Patent: April 2, 2013Assignee: Direvo Industrial Biotechnology GmbHInventors: Nadine Koch, Oliver Kensch, Klaus Schulze-Pellengahr
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Publication number: 20120301578Abstract: The present invention relates to enzymes and processes. In particular, there is described an isolated polypeptide comprising the amino acid sequence corresponding to Citrobacter freundii phytase or a homologue, a modified form, a functional equivalent or an effective fragment thereof. There is also described a host cell transformed or transfected with a nucleic acid encoding a bacterial phytase enzyme or a modified form as well as the use of such a phytase or modified form in food or animal feed.Type: ApplicationFiled: September 14, 2011Publication date: November 29, 2012Inventors: Andrei Miasnikov, Vijay Kumar, Oliver Kensch, Klaus Pellangahr, Birgitta Leuthner, Ulrich Kettling, Andre Koltermann
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Publication number: 20120282239Abstract: The present disclosure provides novel mannanase variants which have an amino acid sequence that varies from that of the parent/wild type Trichoderma reesei mannanase, and which have one or more advantageous properties like improved thermo stability; temperature/activity profile; pH/activity profile; specific activity; and pH/protease-sensitivity. The novel mannanase variants are useful and used in alcohol fermentations processes and/or productions, for coffee extraction and the processing of coffee waste, as a supplement to food and feed, for enzyme aided bleaching of paper pulps, as bleaching and/or desizing agent in textile industry, for oil and gas well stimulation by hydraulic fracturing, as detergent, as baking ingredients, for removal of biofilms and in delivery systems, for grain processing or for the processing of renewable resources intended for the production of biological fuels, and in the textile, oil drilling, cleaning, laundering, detergent, and cellulose fiber processing industries.Type: ApplicationFiled: November 24, 2010Publication date: November 8, 2012Applicant: BASF SEInventor: Oliver Kensch
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Patent number: 8143046Abstract: The present invention relates to variant phytase enzymes having altered properties.Type: GrantFiled: February 6, 2008Date of Patent: March 27, 2012Assignee: Danisco US Inc., Genencor DivisionInventors: Marguerite A. Cervin, Oliver Kensch, Ulrich Kettling, Steven S. Kim, Birgitta Leuthner, Andrei Miasnikov, Michael Ward, Klaus Pellengahr
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Patent number: 8143045Abstract: The present invention relates to enzymes and processes. In particular, there is described an isolated polypeptide comprising the amino acid sequence corresponding to Citrobacter freundii phytase or a homologue, a modified form, a functional equivalent or an effective fragment thereof. There is also described a host cell transformed or transfected with a nucleic acid encoding a bacterial phytase enzyme or a modified form as well as the use of such a phytase or modified form in food or animal feed.Type: GrantFiled: April 3, 2007Date of Patent: March 27, 2012Assignee: Danisco A/SInventors: Andrei Miasnikov, Vijay Kumar, Oliver Kensch, Klaus Pellangahr, Birgitta Leuthner, Ulrich Kettling, Andre Koltermann
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Publication number: 20120064194Abstract: The present invention relates to enzymes and processes. In particular, there is described a host 3140 cell transformed or transfected with a nucleic acid encoding a bacterial phytase enzyme and variants thereof.Type: ApplicationFiled: July 27, 2011Publication date: March 15, 2012Inventors: Andrei Miasnikov, Vijay Kumar, Oliver Kensch, Klaus Pellengahr, Birgitta Leuthner, Ulrich Kettling, Andre Koltermann