Abstract: The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.

Abstract: The present invention includes a process for producing a protein product from plants and yeasts. The process comprises the steps of: a) providing a thin stillage or a thin stillage concentrate; b) separating a protein concentrate from the provided thin stillage from a) by means of solid-liquid separation; c) diluting the protein concentrate from b) with an aqueous process liquid to a dry substance content of at most 15 wt. %, tempering the diluted protein concentrate to a temperature of at least 60° C.

Abstract: The present invention relates to bispecific antibodies against ROR1 and CD3, their manufacture and use.

Abstract: A combine harvester includes a housing having a rear hood and defining an interior, a blower for generating an air stream in a substantially rearward direction, and a cleaning system separating residue from a crop material such that the residue is transported via the air stream rearwardly to be discharged from the housing. A chopper rotor assembly is disposed within the interior below the rear hood and includes a chopper rotor having a plurality of blades for chopping the residue as it is received via the air stream. A chopper housing is disposed within the interior and defines an inlet of the chopper rotor for receiving the residue and an outlet spaced rearward from the chopper rotor for discharge of the chopped residue from the interior of the housing. An air gap through which the air stream may exit the interior is defined between the rear hood and chopper rotor.

Abstract: A combine harvester includes a housing having a rear hood and defining an interior, a blower for generating an air stream in a substantially rearward direction, and a cleaning system separating residue from a crop material such that the residue is transported via the air stream rearwardly to be discharged from the housing. A chopper rotor assembly is disposed within the interior below the rear hood and includes a chopper rotor having a plurality of blades for chopping the residue as it is received via the air stream. A chopper housing is disposed within the interior and defines an inlet of the chopper rotor for receiving the residue and an outlet spaced rearward from the chopper rotor for discharge of the chopped residue from the interior of the housing. An air gap through which the air stream may exit the interior is defined between the rear hood and chopper rotor.

Abstract: The present disclosure relates to methods for enhancing the efficiency of therapies involving immune effector cells such as T cells engineered to express antigen receptors such as T cell receptors (TCRs) or chimeric antigen receptors (CARs). It is demonstrated herein that such antigen receptor-engineered immune effector cells, even when provided to a subject in sub-therapeutic amounts, are extremely effective in the treatment of cancer diseases, even those cancer diseases that are known to be difficult to treat with antigen receptor-engineered immune effector cells, such as solid tumors or cancers, if additionally target antigen for the antigen receptor is provided to the subject. Immune effector cells may be engineered ex vivo or in vitro and subsequently the immune effector cells may be administered to a subject in need of treatment, or immune effector cells may be engineered in vivo in a subject in need of treatment.

Abstract: A harvest header for a harvesting machine includes a carrying frame, a mechanism for receiving or cutting harvest material from a field, a control device, a power-operated actuator operably controlled by the control device, and a transverse conveyor screw movably controlled between two or more positions. The position of the transverse conveyor screw is adjustably controlled by the actuator in order to transport the harvest material to a discharge opening. The control device independently controls the actuator based on at least one harvest material property.

Abstract: A combine harvester includes a load-bearing undercarriage movable via a drivable device engaged in the ground, a threshing and separating device attached to the load-bearing undercarriage, and a feeder house attached to the load-bearing undercarriage. The feeder house includes an endless traction mechanism which circulates about a vertically movable lower deflection roller and a drivable upper deflection roller. A harvesting attachment is coupled to the feeder house for receiving or cutting off harvested crops which are lying or standing upright on a field and which are able to be supplied via the feeder house to the threshing and separating device. An actuator is actuated by an external force arranged for adjusting the vertical position of the lower deflection roller and is connected to a control device which is coupled to a sensor for determining a throughput by a transmission of a signal.

Abstract: A cutter head for a harvester, with a cutterbar for cutting crop from a field, a reel with reel fingers which is disposed above the cutterbar, and a cross conveyor for transporting the cut crop to a rear discharge opening. The reel includes reel arms that can be driven about a rotating axis, reel finger carriers supported on the reel arms so they can rotate about the lengthwise axes of the arms, with reel fingers mounted thereon, and an externally powered actuator connected to an electronic control unit for adjusting the rotary angle of the reel finger carrier relative to the reel arms.

Abstract: A spreader of a combine for conveying crop residue rearwardly from a rotor assembly includes a frame coupled to the combine and has a top portion adapted to receive a portion of crop residue during a harvesting operation. An impellor includes one or more blades for rotatably conveying crop residue rearwardly, and an actuator is controllably moved between an extended position and a retracted position. The actuator is pivotally coupled to the combine. A linkage assembly is pivotally coupled to the actuator at one end and to the frame at another end. The spreader is disposable in a first position when the actuator is in the extended position, and the spreader is disposable in a second position when the actuator is in the retracted position. A movement from the extended position to the retracted position induces pivotal movement of the spreader from the first position to the second position.

Abstract: A combine double-decker crop residue spreader for use with a rotating chopper having chopper blades and through which air is blown may include a divider panel separating a lower portion from an upper portion of the spreader. The divider panel extends rearwardly from a location where the chopper blades transition from rotating towards the divider panel to rotating away from the divider. An airflow conduit extends above the divider panel in the upper portion to rearwardly direct air flow. At least one lower vertical panel below the divider panel in the lower portion rearwardly directs crop residue.

Abstract: A request for contract documentation is received from a provider computer. One or more classifier values associated with the request are compared to one or more values stored in one or more index cores. Based on the determination that a match exists, one or more contracting documents are retrieved from a contracts database, where the contracts database includes the updated format of each of the contracting documents. A contract template is generated including the one or more contracting documents. The contract template is compiled and communicated for signature and subsequent approval.

Abstract: A chopping blade for a straw chopper comprises a fastening opening, two side faces, and cutting edges arranged on one or both ends of the side faces. At least one of the side faces is equipped with means for reducing the frictional resistance of the chopping blade relative to the air and/or the chopping material.

Abstract: An arrangement for switching over a combine harvester between swath deposit operation and wide distribution operation comprises a front element and a rear element which follows downstream. The rear element may be attached in an articulated fashion, in an inherently rigid fashion, at its upstream end about a first pivoting axis and may be moved between a swath deposit position and a wide distribution position by an adjustment drive. The front element may be attached in an articulated fashion at its upstream end about a second pivoting axis, may be inherently rigid and may also be coupled to the adjustment drive.

Abstract: A harvest header for a harvesting machine includes a carrying frame, a mechanism for receiving or cutting harvest material from a field, a control device, a power-operated actuator operably controlled by the control device, and a transverse conveyor screw movably controlled between two or more positions. The position of the transverse conveyor screw is adjustably controlled by the actuator in order to transport the harvest material to a discharge opening. The control device independently controls the actuator based on at least one harvest material property.

Abstract: A combine harvester includes a housing having a rear hood and defining an interior, a blower for generating an air stream in a substantially rearward direction, and a cleaning system separating residue from a crop material such that the residue is transported via the air stream rearwardly to be discharged from the housing. A chopper rotor assembly is disposed within the interior below the rear hood and includes a chopper rotor having a plurality of blades for chopping the residue as it is received via the air stream. A chopper housing is disposed within the interior and defines an inlet of the chopper rotor for receiving the residue and an outlet spaced rearward from the chopper rotor for discharge of the chopped residue from the interior of the housing. An air gap through which the air stream may exit the interior is defined between the rear hood and chopper rotor.

Abstract: A combine harvester includes a load-bearing undercarriage movable via a drivable device engaged in the ground, a threshing and separating device attached to the load-bearing undercarriage, and a feeder house attached to the load-bearing undercarriage. The feeder house includes an endless traction mechanism which circulates about a vertically movable lower deflection roller and a drivable upper deflection roller. A harvesting attachment is coupled to the feeder house for receiving or cutting off harvested crops which are lying or standing upright on a field and which are able to be supplied via the feeder house to the threshing and separating device. An actuator is actuated by an external force arranged for adjusting the vertical position of the lower deflection roller and is connected to a control device which is coupled to a sensor for determining a throughput by a transmission of a signal.

Abstract: A combine harvester includes a housing having a rear hood and defining an interior, a blower for generating an air stream in a substantially rearward direction, and a cleaning system separating residue from a crop material such that the residue is transported via the air stream rearwardly to be discharged from the housing. A chopper rotor assembly is disposed within the interior below the rear hood and includes a chopper rotor having a plurality of blades for chopping the residue as it is received via the air stream. A chopper housing is disposed within the interior and defines an inlet of the chopper rotor for receiving the residue and an outlet spaced rearward from the chopper rotor for discharge of the chopped residue from the interior of the housing. An air gap through which the air stream may exit the interior is defined between the rear hood and chopper rotor.

Abstract: The present disclosure concerns a cutter head for a harvester, with a cutterbar for cutting crop from a field, a reel with reel fingers which is disposed above the cutterbar, and a cross conveyor for transporting the cut crop to a rear discharge opening. The reel includes reel arms that can be driven about a rotating axis, reel finger carriers supported on the reel arms so they can rotate about the lengthwise axes of the arms, with reel fingers mounted thereon, and an externally powered actuator connected to an electronic control unit for adjusting the rotary angle of the reel finger carrier relative to the reel arms.

Abstract: A combine harvester has a straw chute with a straw conveyor which comprises a conveyor rotor which can be set into rotation and has dogs distributed helically around the conveyor rotor.