Abstract: A method for operating a vehicle includes monitoring for a presence of an assigned authorization element in the vehicle during operating the vehicle and operating the vehicle in a secure state when the assigned authorization element is not detected, where a performance parameter of the vehicle is at least temporarily modified in the secure state.

Abstract: The present invention relates to small molecule compounds of formula (I) and their use as FLT3 inhibitors for the treatment of various diseases, such as acute myeloid leukemia (AML). The present invention further relates to methods of synthesizing the compounds and methods of treatment.

Abstract: The present invention relates to small molecule compounds of formula (I) and their use as FLT3 inhibitors for the treatment of various diseases, such as acute myeloid leukemia (AML). The present invention further relates to methods of synthesizing the compounds and methods of treatment.

Abstract: The invention relates to a process for the production of finished parts made of at least one multilayer, fiber-reinforced, flat semifinished-product structure, comprising the following steps: a) heating of the at least one multilayer, fiber-reinforced, flat semifinished-product structure at ambient pressure to a first temperature Ta, where the at least one multilayer, fiber-reinforced, flat semifinished-product structure comprises at least two mutually superposed polymer layers and the individual polymer layers respectively have fiber-reinforcement and do not have coherent bonding to one another or have only partial coherent bonding to one another, and in the event that at least one of the polymer layers comprises a semicrystalline polymer the first temperature Ta is higher than a melting point Tm of the crystalline polymer in accordance with DIN EN ISO 11357-3:2013-04, and in the event that the at least two polymer layers comprise no semicrystalline polymer the first temperature Ta is higher than a glass

Abstract: The present invention relates to small molecule compounds and their use as HDAC inhibitors and in the treatment of various diseases, such as cancer. The present invention further relates to methods of synthesizing the compounds and methods of treatment. H-L(HA), H is a head group selected from (head group 1), (head group 2), (head group 3), (head group 4), (head group 5) and (head group 6).

Abstract: The invention relates to a process for the production of finished parts made of at least one multilayer, fiber-reinforced, flat semifinished-product structure, comprising the following steps: a) heating of the at least one multilayer, fiber-reinforced, flat semifinished-product structure at ambient pressure to a first temperature Ta, where the at least one multilayer, fiber-reinforced, flat semifinished-product structure comprises at least two mutually superposed polymer layers and the individual polymer layers respectively have fiber-reinforcement and do not have coherent bonding to one another or have only partial coherent bonding to one another, and in the event that at least one of the polymer layers comprises a semicrystalline polymer the first temperature Ta is higher than a melting point Tm of the crystalline polymer in accordance with DIN EN ISO 11357-3:2013-04, and in the event that the at least two polymer layers comprise no semicrystalline polymer the first temperature Ta is higher than a glass

Abstract: Some embodiments relate to methods for the recombinant expression of a protein of interest in a mammalian host cell, use of an shRNA or an siRNA directed against the Galectin-1 gene for increasing the expression of a protein of interest in a mammalian host cell and kits comprising an shRNA or an siRNA and a CHO cell.

Abstract: An operating device for a household appliance includes an electronic display panel, and an operating element that is displaceable relative to the display panel to set operating conditions of the household appliance. The operating element has a region which is disposed within an area of the display panel.

Abstract: The present invention relates to small molecule compounds and their use as HDAC inhibitors and in the treatment of various diseases, such as cancer. The present invention further relates to methods of synthesizing the compounds and methods of treatment. H-L(HA), H is a head group selected from (head group 1), (head group 2), (head group 3), (head group 4), (head group 5) and (head group 6).

Abstract: The present invention provides a temperature-regulating element (1) having a thermally conductive surface (3) and a thermally insulating surface (5), said temperature-regulating element comprising a metallic plate (7) having elevations (9), a main body (11) composed of plastic and two connection components (17a, 17b) comprised of plastic. At least one continuous channel (13) for receiving a temperature-regulating medium is formed between the metallic plate (7) and the main body (11), said at least one continuous channel extending from one end face (15a) to an opposite end face (15b) of the main body (11) and being connected to a temperature-regulating medium circuit by the connection components (17a, 17b). The temperature-regulating element (1) is designed such that the main body (11) at least partly surrounds the metallic plate (7).

Abstract: Some embodiments relate to methods for the recombinant expression of a protein of interest in a mammalian host cell, use of an sh RNA or an si RNA directed against the Galectin-1 gene for increasing the expression of a protein of interest in a mammalian host cell and kits comprising an shRNA or an si RNA and a CHO cell.

Abstract: A filter unit for an extractor hood includes at least one filter element, and at least one protection plate which is arranged in a flow direction upstream of the filter element. The protection plate is made of at least two layers and can have a thickness in a range of 0.5 mm to 10 mm.

Abstract: The present invention encompasses compounds of general Formula (1) wherein R1 to R4 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.

Abstract: The present invention provides a temperature-regulating element (1) having a thermally conductive surface (3) and a thermally insulating surface (5), said temperature-regulating element comprising a metallic plate (7) having elevations (9), a main body (11) composed of plastic and two connection components (17a, 17b) comprised of plastic. At least one continuous channel (13) for receiving a temperature-regulating medium is formed between the metallic plate (7) and the main body (11), said at least one continuous channel extending from one end face (15a) to an opposite end face (15b) of the main body (11) and being connected to a temperature-regulating medium circuit by the connection components (17a, 17b). The temperature-regulating element (1) is designed such that the main body (11) at least partly surrounds the metallic plate (7).

Abstract: A method is provided for operating a hybrid vehicle equipped with an internal-combustion engine and an electric drive for generating vehicle propulsion. The vehicle selectively is driven in a first operating mode exclusively by the electric drive or in a second operating mode is driven by the internal combustion engine and by the electric drive, or in a third operating mode is driven exclusively by the internal combustion engine. In the first operating mode, the driver predefines a desired driving torque via a selection element. The first operating mode is maintained even if the desired driving torque is greater than a maximal driving torque that can presently be supplied by the electric motor.

Abstract: A system and method that improve service and device discovery in a UPnP-based wireless communication network and avoids unnecessary broadcast messages on a MAC sublayer of a DLC layer caused by UPnP multicast messages on an IP layer by intercepting UPnP multicast messages in a network protocol stack below the IP layer. A module intercepts multicast UDP packets destined to a UPnP IP multicast address and port, the multicast UDP packets containing UPnP packets as payload. The module executes DLC/MAC-based service discovery functions to perform wireless network-specific device discovery and to find UPnP-enabled devices in the wireless communication network. Once a wireless network device discovery has returned nodes that fulfill criteria given in the search, the module uses unicast DLC/MAC messages to send UPnP packets to only those nodes that are UPnP-enabled and whose device type matches the respective UPnP device type sought.