Patents by Inventor OLIVER LIU

OLIVER LIU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240159645
    Abstract: Synthetic human cell mimic hydrogel particles and their use in cytometric or coulter device applications are described. The synthetic human cell mimic hydrogel particles described herein are selectively tunable to have at least one optical, volumetric, or capacitance property that is substantially similar to a corresponding optical, volumetric, or capacitance property of the human cell mimic hydrogel particle's natural biological cell counterpart.
    Type: Application
    Filed: January 19, 2024
    Publication date: May 16, 2024
    Applicant: Slingshot Biosciences, Inc.
    Inventors: Jeffrey KIM, Oliver LIU, Jeremy AGRESTI, Anh Tuan NGUYEN
  • Patent number: 11927519
    Abstract: Synthetic human cell mimic hydrogel particles and their use in cytometric or coulter device applications are described. The synthetic human cell mimic hydrogel particles described herein are selectively tunable to have at least one optical, volumetric, or capacitance property that is substantially similar to a corresponding optical, volumetric, or capacitance property of the human cell mimic hydrogel particle's natural biological cell counterpart.
    Type: Grant
    Filed: April 26, 2023
    Date of Patent: March 12, 2024
    Assignee: Slingshot Biosciences, Inc.
    Inventors: Jeffrey Kim, Oliver Liu, Jeremy Agresti, Anh Tuan Nguyen
  • Publication number: 20240013862
    Abstract: The present disclosure provides methods and systems for identifying insecticidal protein-encoding GIs (GIs). The present disclosure also teaches methods for producing sequenced and assembled metagenomic libraries that are amenable to GI search bioinformatic tools and techniques.
    Type: Application
    Filed: September 29, 2021
    Publication date: January 11, 2024
    Inventors: Oliver LIU, Sangita GANESH
  • Publication number: 20230297943
    Abstract: A method of facilitating a product return transaction may include receiving product return data from a merchant indicating merchant-specific information on product returns to the merchant and receiving an indication of a product return request from a customer. The method may further include employing a trained model to determine a likelihood of return rating associated with physical receipt of a returned product associated with the product return request based on the product return data, responsive to the likelihood of return rating exceeding a threshold, extending a credit to the customer based on a value of the returned product, and enabling the customer to initiate a product repurchase using the credit.
    Type: Application
    Filed: March 18, 2022
    Publication date: September 21, 2023
    Inventors: Mark L Sainz Zaragoza, Hossein Ghodrati Noushahr, Pablo Lopez Alvarez, Enric Gili Fort, Oliver Liu, Eduardo Vilar
  • Publication number: 20230298029
    Abstract: A method of evaluating a merchant cash advance option may include receiving time series information including a plurality of signals representing transactions of merchants and customers where at least one of the signals relates to product returns. The method may further include aggregating the time series information, generating a plurality of trained models associated with the product returns, employing a selected model to forecast return volume and repurchase volume for a given merchant, determining a risk assessment value for the given merchant, and, if the risk assessment value is below a risk threshold, providing an offer of a merchant cash advance to the given merchant based on the forecast return volume and repurchase volume.
    Type: Application
    Filed: March 17, 2022
    Publication date: September 21, 2023
    Inventors: Pablo Lopez Alvarez, Enric Gili Fort, Mark L Sainz Zaragoza, Oliver Liu, Eduardo Vilar
  • Patent number: 11761877
    Abstract: Hydrogel particles and their use in cytometric applications are described. The hydrogel particles described herein are selectively tunable to have at least one optical property substantially similar to at least one optical property of a target cell. In this regard, the hydrogel particles provided herein, in one aspect, are used as a calibration reagent for the detection of a target cell in a sample.
    Type: Grant
    Filed: April 28, 2022
    Date of Patent: September 19, 2023
    Assignee: Slingshot Biosciences, Inc.
    Inventors: Jeffrey Kim, Oliver Liu, Jeremy Agresti, Anh Tuan Nguyen
  • Patent number: 11747261
    Abstract: Hydrogel particles and their use in cytometric applications are described. The hydrogel particles described herein are selectively tunable to have at least one optical property substantially similar to at least one optical property of a target cell. In this regard, the hydrogel particles provided herein, in one aspect, are used as a calibration reagent for the detection of a target cell in a sample.
    Type: Grant
    Filed: July 20, 2020
    Date of Patent: September 5, 2023
    Assignee: Slingshot Biosciences, Inc.
    Inventors: Jeffrey Kim, Oliver Liu, Jeremy Agresti, Anh Tuan Nguyen
  • Publication number: 20230266223
    Abstract: Synthetic human cell mimic hydrogel particles and their use in cytometric or coulter device applications are described. The synthetic human cell mimic hydrogel particles described herein are selectively tunable to have at least one optical, volumetric, or capacitance property that is substantially similar to a corresponding optical, volumetric, or capacitance property of the human cell mimic hydrogel particle's natural biological cell counterpart.
    Type: Application
    Filed: April 26, 2023
    Publication date: August 24, 2023
    Applicants: Slingshot Biosciences, Inc., Slingshot Biosciences, Inc.
    Inventors: Jeffrey KIM, Oliver LIU, Jeremy AGRESTI, Anh Tuan NGUYEN
  • Patent number: 11686661
    Abstract: Hydrogel particles and their use in cytometric applications are described. The hydrogel particles described herein are selectively tunable to have at least one optical property substantially similar to at least one optical property of a target cell. In this regard, the hydrogel particles provided herein, in one aspect, are used as a calibration reagent for the detection of a target cell in a sample.
    Type: Grant
    Filed: November 18, 2022
    Date of Patent: June 27, 2023
    Assignee: Slingshot Biosciences, Inc.
    Inventors: Jeffrey Kim, Oliver Liu, Jeremy Agresti, Anh Tuan Nguyen
  • Publication number: 20230187027
    Abstract: The present disclosure provides methods and systems for identifying natural product-encoding multi-gene clusters (MGCs). In some embodiments, the present disclosure also teaches methods for producing sequenced and assembled metagenomic libraries that are amenable to MGC search bionformatic tools and techniques.
    Type: Application
    Filed: September 23, 2022
    Publication date: June 15, 2023
    Inventors: Oliver LIU, Eyal AKIVA, Tom Hayon EYLES, Ute GALM, Sangita GANESH, Stephanie Leanne Brown HENDRIX, William W. HWANG, Jeffrey Hoon KIM, Alexander NECKELMANN, Samuel OTENG-PABI, Claus PELIKAN, Devin SCANNELL, Zachariah SERBER, Jennifer SHOCK, Michael W. SNEDDON, Xiao YANG
  • Publication number: 20230152202
    Abstract: Hydrogel particles and their use in cytometric applications are described. The hydrogel particles described herein are selectively tunable to have at least one optical property substantially similar to at least one optical property of a target cell. In this regard, the hydrogel particles provided herein, in one aspect, are used as a calibration reagent for the detection of a target cell in a sample.
    Type: Application
    Filed: November 18, 2022
    Publication date: May 18, 2023
    Applicant: Slingshot Biosciences, Inc.
    Inventors: Jeffrey KIM, Oliver LIU, Jeremy AGRESTI, Anh Tuan NGUYEN
  • Patent number: 11618898
    Abstract: The disclosure provides compositions and methods for producing natural products in microorganisms that are otherwise unexpressed, poorly expressed or poorly transcribed. In particular aspects, the disclosure provides compositions and methods for activating a silent gene or gene cluster with a bacteriophage and/or Streptomyces Antibiotic Regulatory Protein (SARP) transcription factor.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: April 4, 2023
    Assignee: Zymergen Inc.
    Inventors: Oliver Liu, Jeffrey Hoon Kim
  • Publication number: 20230067460
    Abstract: The present disclosure provides feeder hydrogel particles that can function to support the growth, proliferation, and/or activation of a target cell in culture. The present disclosure also provides methods of culturing target cells with feeder hydrogel particles.
    Type: Application
    Filed: October 28, 2022
    Publication date: March 2, 2023
    Inventors: Anh Tuan NGUYEN, Jeffrey KIM, Keunho AHN, Oliver LIU, Jeremy AGRESTI
  • Patent number: 11495326
    Abstract: The present disclosure provides methods and systems for identifying natural product-encoding multi-gene clusters (MGCs). In some embodiments, the present disclosure also teaches methods for producing sequenced and assembled metagenomic libraries that are amenable to MGC search bioinformatic tools and techniques.
    Type: Grant
    Filed: September 21, 2021
    Date of Patent: November 8, 2022
    Assignee: Zymergen Inc.
    Inventors: Oliver Liu, Eyal Akiva, Tom Hayon Eyles, Ute Galm, Sangita Ganesh, Stephanie Leanne Brown Hendrix, William W. Hwang, Jeffrey Hoon Kim, Alexander Neckelmann, Samuel Oteng-Pabi, Claus Pelikan, Devin Scannell, Zachariah Serber, Jennifer Shock, Michael W. Sneddon, Xiao Yang
  • Publication number: 20220260476
    Abstract: Hydrogel particles and their use in cytometric applications are described. The hydrogel particles described herein are selectively tunable to have at least one optical property substantially similar to at least one optical property of a target cell. In this regard, the hydrogel particles provided herein, in one aspect, are used as a calibration reagent for the detection of a target cell in a sample.
    Type: Application
    Filed: April 28, 2022
    Publication date: August 18, 2022
    Applicant: Slingshot Biosciences, Inc.
    Inventors: Jeffrey KIM, Oliver LIU, Jeremy AGRESTI, Anh Tuan NGUYEN
  • Publication number: 20220178810
    Abstract: The present disclosure relates to compositions comprising a hydrogel particle with optical properties substantially similar to the optical properties of a target cell, and methods for their use.
    Type: Application
    Filed: September 10, 2021
    Publication date: June 9, 2022
    Applicant: SLINGSHOT BIOSCIENCES
    Inventors: Jeffrey KIM, Oliver LIU, Jeremy AGRESTI, Anh Tuan NGUYEN
  • Publication number: 20220005550
    Abstract: The present disclosure provides methods and systems for identifying natural product-encoding multi-gene clusters (MGCs). In some embodiments, the present disclosure also teaches methods for producing sequenced and assembled metagenomic libraries that are amenable to MGC search bionformatic tools and techniques.
    Type: Application
    Filed: September 21, 2021
    Publication date: January 6, 2022
    Inventors: Oliver LIU, Eyal AKIVA, Tom Hayon EYLES, Ute GALM, Sangita GANESH, Stephanie Leanne Brown HENDRIX, William W. HWANG, Jeffrey Hoon KIM, Alexander NECKELMANN, Samuel OTENG-PABI, Claus PELIKAN, Devin SCANNELL, Zachariah SERBER, Jennifer SHOCK, Michael W. SNEDDON, Xiao YANG
  • Patent number: 11189362
    Abstract: The present disclosure provides methods and systems for identifying natural product-encoding multi-gene clusters (MGCs). In some embodiments, the present disclosure also teaches methods for producing sequenced and assembled metagenomic libraries that are amenable to MGC search bionformatic tools and techniques.
    Type: Grant
    Filed: February 16, 2021
    Date of Patent: November 30, 2021
    Assignee: Zymergen Inc.
    Inventors: Oliver Liu, Eyal Akiva, Tom Hayon Eyles, Ute Galm, Sangita Ganesh, Stephanie Leanne Brown Hendrix, William W. Hwang, Jeffrey Hoon Kim, Alexander Neckelmann, Samuel Oteng-Pabi, Claus Pelikan, Devin Scannell, Zachariah Serber, Jennifer Shock, Michael Sneddon, Xiao Yang
  • Publication number: 20210277414
    Abstract: The disclosure presents a platform for discovering novel insecticidal proteins from highly heterogeneous environmental sources. The methodology utilizes metagenomic enrichment procedures and unique genetic amplification techniques, which enables access to a broad class of unknown microbial diversity and their resultant proteome. The disclosed insecticidal protein discovery platform (IPDP) can be computationally driven and is able to integrate molecular biology, automation, and advanced machine learning protocols. The platform will enable researchers to rapidly and accurately access the vast repertoire of untapped insecticidal proteins produced by uncharacterized and complex microbial environmental samples. Also presented herein are a group of newly discovered pore-forming toxins (PFT) from a rare class of insecticidal proteins, which were discovered utilizing the insecticidal protein discovery platform.
    Type: Application
    Filed: May 24, 2021
    Publication date: September 9, 2021
    Inventors: William W. HWANG, Jeffrey KIM, Oliver LIU, Jennifer SCHOCK
  • Publication number: 20210277390
    Abstract: The disclosure is directed to an approach for discovering novel insecticidal proteins from highly heterogeneous environmental sources. The methodology utilizes metagenomic enrichment procedures that increase the representation of specific genera of bacteria, prior to deep sequencing, in order to access novel variants of insecticidal proteins. In aspects, the taught methods are useful for creating large genomic libraries enriched for Bacillus sp. The enriched genomic libraries are useful for the discovery of novel cry toxin genes, which enable the identification of novel Cry proteins.
    Type: Application
    Filed: May 17, 2021
    Publication date: September 9, 2021
    Inventors: Jeffrey KIM, Oliver LIU, Jennifer SHOCK, Maritza DUARTE