Patents by Inventor Oliver M. Colvin

Oliver M. Colvin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for evaluating the ability to metabolize pharmaceuticals
    Patent number: 6929912
    Abstract: Methods for detecting variant genes having a polymorphism associated with reduced metabolism of a substrate selected from the group consisting of a CYP3A4 substrate, a CYP3A5 substrate and a GSTM1 substrate in an individual are disclosed. The methods are genotyping methods to identify specific polymorphisms which have been found to be associated with reduced metabolism of chemotherapeutic agents, such as cyclophosphamide and BCNU. Also disclosed are novel polymorphic nucleic acid molecules useful in the methods of the invention.
    Type: Grant
    Filed: February 26, 2002
    Date of Patent: August 16, 2005
    Assignees: Genaissance Pharmaceuticals, Inc., Duke University
    Inventors: Marco Guida, Jeff Hall, William P. Petros, James J. Vredenburgh, Oliver M. Colvin, Jeffrey R. Marks
  • Methods for evaluating the ability to metabolize pharmaceuticals and compositions therefor
    Publication number: 20030096251
    Abstract: Methods for detecting variant genes having a polymorphism associated with reduced metabolism of a substrate selected from the group consisting of a CYP3A4 substrate, a CYP3A5 substrate and a GSTM1 substrate in an individual are disclosed. The methods are genotyping methods to identify specific polymorphisms which have been found to be associated with reduced metabolism of chemotherapeutic agents, such as cyclophosphamide and BCNU. Also disclosed are novel polymorphic nucleic acid molecules useful in the methods of the invention.
    Type: Application
    Filed: February 26, 2002
    Publication date: May 22, 2003
    Inventors: Marco Guida, Jeff Hall, William P. Petros, James J. Vredenburgh, Oliver M. Colvin, Jeffrey R. Marks