Abstract: The invention relates to an emblem (80) for a motor vehicle (1), comprising an optical sensor system (30) which is suitable for a) monitoring a detection region (21) lying outside of the motor vehicle (1), b) triggering a signal for starting an authentication check between an ID transmitter (13) and the motor vehicle (1) in the event that a user (10) is detected in the detection region (21), c) monitoring an actuation region (22) which lies outside of the motor vehicle (1) and which differs from the detection region (21), and d) providing an operating signal for the motor vehicle (1) in the event that a user (10) is detected in the actuation region (22).

Abstract: The invention relates to an assembly module (20) for a motor vehicle (1), comprising an optical sensor system (30) which is suitable a) for monitoring a detection area (21) located outside of the vehicle (1), b) if a user (10) is detected in the detection area (21), for triggering a signal to commence an authentication check between an ID transponder (13) and the motor vehicle (1), c) for monitoring an actuation area (22) which is located outside of the vehicle (1) and which is different from the detection area (21), d) if a user (10) is detected in the actuation area (22), for providing a working signal for the vehicle (1), wherein an emergency actuation means (90) is provided for additionally triggering the working signal, which emergency actuation means is suitable e) for providing a working signal for the vehicle (1) via an activation of the emergency actuation means (90) by a body part (11, 12) of the user (10).

Abstract: The invention relates to an assembly module (20) for a motor vehicle, comprising an optical sensor system (30), which can be used to a) monitor a detection area (21) on the outside of the motor vehicle (1) in order to determine the proximity of a user (10), b) in the event a user (10) is detected in the detection area (21), a signal for starting an authentication test between an ID transmitter (13) and an access control system (14) of the motor vehicle (1) is triggered.

Abstract: The invention relates to an assembly module (20) for a motor vehicle (1), said assembly module having an optical sensor system (30) which is suitable a) for monitoring an activation region (22) outside of the motor vehicle (1) during an activation duration in order to identify a user's intention in the activation region (22), b) for providing a working signal in the case that a user's intention has been identified. According to the invention, auxiliary means (31, 43, 45, 80) are provided which help the user (10) to make the user's intention in the activation region (22, 28) known so that the working signal can be provided.

Abstract: The invention relates to an assembly module (20) for a motor vehicle (1), comprising an optical sensor system (30) which can be used a) to monitor a detection area (150) on the outside of the motor vehicle (1) in order to determine the proximity of a user (10), b) to measure the distance to the user (10) within the detection area (150) and c) to release a signal for carrying out an action on the motor vehicle (1) in the event a user (10) is detected in a predefined actuation area (180) within the detection area (150).

Abstract: An electronic assembly for a motor vehicle includes a housing, a control and evaluation device disposed in the housing which is adapted to be coupled to a control device of the motor vehicle and an illumination device coupled to the control and evaluation device. The illumination device is adapted to be actuated by the control and evaluation device. A target area characterizing a detection area outside of the housing can be marked by an optical signal. The illumination device is adapted to be activated by the control and evaluation device for emitting light with different colors.

Abstract: The disclosure relates to a pixel array for an electrofluidic display element, comprising a plurality of adjacent pixels that form the pixel array, each pixel having a pixel chamber with a polygonal, preferably rectangular, pixel surface and a height. Each pixel has at least one main reservoir channel which opens, via a first width (D) and length (L), into the pixel chamber and a single- or multi-part reservoir channel which surrounds the chamber, borders the pixel surface and opens, along its length and a second width into the pixel chamber. A polar and/or electrically conductive liquid is or can be held in the pixels, said liquid being capable of motion back-and-forth between the reservoir channels and the pixel chamber by the application of an electric field, and the reservoir channels surrounding adjacent pixels run towards each other in a corner region in which the adjacent pixels border one another.

Abstract: A closed loop handlebar locking device is securely coupled to a bike and allows safe and accurate steering and operation of the bike when in use. The handlebar locking device is further suitable for securely locking the bike when the bike is not in use. Handlebar locking device is configurable to lock a bike to a fixed object, such as a signpost while still attached to the stem of the bike. The handlebar locking device is also configurable to lock the bike when a suitable object, such as a signpost is not available. In such a situation the handlebar locking device may be removed from the stem and passed around the frame and through one or both wheels. The handlebar locking device is attached to the stem via a stem piece that remains attached to the stem when the handlebar locking device is detached. Brakes, lights, computer and other accessories and components are attached to the stem piece. The bike is unsuitable for operation even if the handlebar locking device is defeated by a would-be thief.

Abstract: To produce a display element for an electrowetting display, there is provided a quantity of fluid which is greater than both the first volume of a display chamber and the second volume of a reservoir chamber, but less than the sum of the first volume and second volume. The fluid is divided into first and second partial drops, the first being introduced into the display chamber, the second being introduced into the reservoir chamber. The display and reservoir chambers are brought together so that a first opening in a first intermediate film of the display chamber and a second opening in a second intermediate film of the reservoir chamber at least partly overlap. An electrical field is applied to the display chamber and to the reservoir chamber, thereby uniting the first partial drop and the second partial drop.

Abstract: The present invention relates to a gene therapy vector which is useful in the treatment or prevention of hypertrophic cardiomyopathy in a subject in need thereof. The gene therapy vector of the invention comprises a nucleic acid sequence encoding a cardiac sarcomeric protein and a cardiomyocyte-specific promoter which is operably linked to said nucleic acid sequence. The invention furthermore relates to a cell which comprises the gene therapy vector. Pharmaceutical compositions which comprise the gene therapy vector and/or a cell comprising said vector are also provided. In another aspect, the invention relates to a method for treating or preventing hypertrophic cardiomyopathy in a subject by introducing the gene therapy vector of the invention into a subject in need of treatment.

Abstract: The present invention relates to Abhydrolase containing domain 5 (ABHD5) and N-terminal fragments of HDAC4 (HDAC4-NT) and variants of the aforementioned peptides for the treatment and prevention of heart failure. The present invention further provides vectors for the cardiomyocyte-specific expression of said peptides and a test system comprising ABHD5 for the identification of novel compounds which are useful for the treatment of heart failure.

Abstract: A device for amplifying a laser beam is provided. The device includes at least one amplifier chamber in which a laser-active material is provided, at least one transmitting optical member delimiting the amplifier chamber and being arranged at a tilt angle, ?, with respect to a plane oriented perpendicularly with respect to an optical axis of the laser beam, and at least one detection unit. The laser beam is reflected by the transmitting optical member into a back reflected laser beam, and the detection unit is arranged such that it detects the back reflected laser beam.

Abstract: The invention relates to a fluidic, in particular an electrofluidic display element, comprising at least one pixel chamber (1) which is in fluid communication with at least one reservoir volume (2), wherein an electrically conducting and/or polar liquid (3) can be reciprocated between the pixel chamber (1) and the reservoir volume (2), wherein the pixel chamber (1) has a height (H) and a pixel width (B) and the reservoir volume (2) has a reservoir width (D) and a length (L), characterized in that the width (D) of the reservoir volume (2) is insignificantly greater than or equal to the height (H) of the pixel chamber (1).

Abstract: A device for displaying information comprising at least one display element which includes: a liquid, the surface energy thereof being variable by means of an electric field; a first and a second volume for receiving the liquid, wherein said first and said second volume are defined by a first effective radius or a second effective radius, respectively, a fluidic passage between said first and said second volume, wherein in a first state said liquid substantially occupies said first volume and wherein in a second state said liquid substantially occupies said second volume, is characterized in that said passage is configured such that the fraction of the liquid facing to the unoccupied volume comprises a radius which is smaller than the effective radius of the presently occupied volume.

Abstract: The invention relates to a fluidic, in particular an electrofluidic display element, comprising at least one pixel chamber (1) which is in fluid communication with at least one reservoir volume (2), wherein an electrically conducting and/or polar liquid (3) can be reciprocated between the pixel chamber (1) and the reservoir volume (2), wherein the pixel chamber (1) has a height (H) and a pixel width (B) and the reservoir volume (2) has a reservoir width (D) and a length (L), characterized in that the width (D) of the reservoir volume (2) is insignificantly greater than or equal to the height (H) of the pixel chamber (1).

Abstract: The invention relates to a display apparatus having at least one electronically controllable display element that comprises: at least one nonpolar and at least two electrically conductive or polar liquids; a fluidically sealed volume having a visible sub-volume and at least two holding volumes connected fluidically to the visible sub-volume; and at least one voltage source that is applied to a first electrode arrangement; the visible sub-volume being of planar embodiment so that when the first electrode arrangement is in the zero-voltage state, the electrically conductive or polar liquids are drawn into the respective holding volume; and the display element furthermore comprising mechanical and/or electrical means for selectably retaining in their holding volumes those electrically conductive or polar liquids which are not intended to be moved into the visible sub-volume by an impingement of voltage on the first electrode arrangement.

Abstract: The invention relates to a display device having at least one electrically controllable display element comprising a first and at least one further liquid, a plurality of fluidically closed volumes and at least one voltage source which is connected to an electrode array, wherein said volumes include flat visible subvolumes which stacked upon another along their shortest dimension, having associated second subvolumes which pass through those flat visible subvolumes which are underlying that flat visible subvolume which is associated with the respective second subvolume.

Abstract: The invention relates to a display element for the display of a plurality of a colors and a method for their display. For this purpose, the invention teaches a display element 1 based on one or more color-producing surfaces 2 which can be oriented parallel to the viewing direction 3 of an observer, for example, so that the observer views only the narrow edges of the surfaces 2. The actual content is perceptible only because a movable reflector 4 is also provided in which the color-producing surface 2 is reflected. The display element claimed by the invention has a particularly good aperture. In the case of static images, the power consumption of the display element is very low. In one preferred embodiment, the display element also makes possible the presentation of a large color space and can be independent of the presence of ambient light.

Abstract: The present invention is concerned with the provision of a polynucleotide encoding an AAV capsid polypeptide comprising an inserted peptide and a vector comprising said polynucleotide. Moreover, contemplated is a host cell comprising said polynucleotide or vector, a method for the manufacture of said capsid polypeptide as well as said polypeptide. Further included is an antibody specifically binding to said polypeptide and a medicament comprising said polynucleotide, vector, polypeptide, or antibody. Also contemplated are the use of said polynucleotide, vector, polypeptide, or antibody for the manufacture of a medicament for the treatment of vascular disease and a method for the identification of a compound binding to said polypeptide.

Abstract: The invention relates to a security element including at least one display element for non-resettable visible display of information, wherein said display element comprises a first and a second volume which are fluidically connected via at least one duct, and only one electrically controllable electrode which is associated to one of said volumes and is configured, when charged with an electric voltage, to vary the surface tension of a liquid which is present in said associated volume, wherein said liquid comprises at least an electrically conducting and/or polar and a non-polar fraction, and at least said electrically conducting fraction being completely and in a stable manner provided in that of both volumes which is not associated with an electrode and wherein said electrically conducting and/or polar fraction may be moved irreversibly and at least partly due to a single charging of the electrode into the volume which is associated with an electrode.