Abstract: The present invention relates to Abhydrolase containing domain 5 (ABHD5) and N-terminal fragments of HDAC4 (HDAC4-NT) and variants of the aforementioned peptides for the treatment and prevention of heart failure. The present invention further provides vectors for the cardiomyocyte-specific expression of said peptides and a test system comprising ABHD5 for the identification of novel compounds which are useful for the treatment of heart failure.

Abstract: The present invention relates to a compound decreasing the concentration of 2-hydroxy-glutarate (2HG) in a subject for use in treating, preventing, and/or preventing progression of cardiac remodeling, in particular cardiomyopathy and/or heart failure and to viral particles, compositions, uses and methods related thereto.

Abstract: The various implementations described herein include a video camera assembly that includes: (1) a housing; (2) an image sensor encased in the housing and configured to capture activity of the smart home environment; (3) a wireless radio configured to transmit video frames captured by the image sensor to an electronic device via a remote server; (4) at least one infrared transmitter configured to selectively illuminate the smart home environment; (5) one or more circuit boards encased in the housing, the one or more circuit boards including at least one processor mounted thereon; and (6) a heating component coupled to the image sensor, the heating component configured to continuously maintain the image sensor at a temperature above a threshold temperature while the image sensor is capturing the activity of the smart home environment.

Abstract: An attachment mechanism for mounting an electronic device to a surface including a mounting plate configured to attach to the surface, the mounting plate having at least one projection, and a base configured to releasably couple to the mounting plate. The base may include a first biasing member, and a first arm pivotably coupled to the base and biased toward a first direction by the first biasing member, the first arm configured to interlock with the at least one projection when the base is coupled to the mounting plate. The base may further include a release mechanism coupled to the first arm such that actuation of the release mechanism when the base is coupled to the mounting plate in a secured engagement causes movement of the first arm in a second direction to disengage the first arm from the at least one projection to enable detachment of the base from the mounting plate.

Abstract: The various implementations described herein include a video camera assembly that includes: (1) a housing; (2) an image sensor positioned within the housing and having a field of view corresponding to a scene in the smart home environment; and (3) a concave-shaped front face positioned in front of the image sensor such that light from the scene passes through the front face prior to entering the image sensor; where the front face includes: (a) an inner section corresponding to the image sensor; and (b) an outer section between the housing and the inner section, the outer section having a concave shape that extends from an outer periphery of the outer section to an inner periphery of the outer section; and where the concave shape extends around an entirety of the outer periphery.

Abstract: The invention relates to an assembly module (20) for a motor vehicle (1), comprising an optical sensor system (30) which is suitable a) for monitoring a detection area (21) located outside of the vehicle (1), b) if a user (10) is detected in the detection area (21), for triggering a signal to commence an authentication check between an ID transponder (13) and the motor vehicle (1), c) for monitoring an actuation area (22) which is located outside of the vehicle (1) and which is different from the detection area (21), d) if a user (10) is detected in the actuation area (22), for providing a working signal for the vehicle (1), wherein an emergency actuation means (90) is provided for additionally triggering the working signal, which emergency actuation means is suitable e) for providing a working signal for the vehicle (1) via an activation of the emergency actuation means (90) by a body part (11, 12) of the user (10).

Abstract: The various implementations described herein include a video camera assembly that includes: (1) a housing; (2) an image sensor positioned within the housing and having a field of view corresponding to a scene in the smart home environment; and (3) a concave-shaped front face positioned in front of the image sensor such that light from the scene passes through the front face prior to entering the image sensor; where the front face includes: (a) an inner section corresponding to the image sensor; and (b) an outer section between the housing and the inner section, the outer section having a concave shape that extends from an outer periphery of the outer section to an inner periphery of the outer section; and where the concave shape extends around an entirety of the outer periphery.

Abstract: Techniques are disclosed for systems and methods to provide a configurable electric micro-mobility vehicle that can be configured with modular accessories. The micro-mobility vehicle is configurable by including a structure that is adapted to receive and secure one or more of the modular accessories within a short amount of time. The micro-mobility vehicle may include a battery compartment for receiving a modular battery pack and securing the battery pack to an electrical connector of the micro-mobility vehicle. The battery compartment may be physically coupled to a seat tube of the micro-mobility vehicle. The battery compartment may include an opening at one end of the battery compartment for inserting and removing a battery pack.

Abstract: The present invention relates to a modified viral structural protein (VSP) as a tool for specifically targeting a chimeric antigen receptor (CAR) expressed on cells of the immune system. The modified VSPs can assemble into virus like particles (VLP). Exposed areas of the VSPs are modified to comprise in a region located atthe surface of a higher order structure, e.g. such as a capsomeric structure, a capsid, a VLP, a viral vector or a virus, a ligand specifically binding to a CAR (LCAR). The present invention thus, provides a modified VSP. The invention also relates to a nucleic acid encoding said VSP. Further, the invention relates to a capsomeric structure, a capsid, a VLP, a viral vector or a virus comprising at least one VSP. Further, the invention relates to a pharmaceutical composition comprising the VSP, the nucleic acid, the capsomeric structure, the capsid, the VLP, the viral vector or the virus comprising at least one VSP.

Abstract: The various implementations described herein include a video camera assembly that includes: (1) a housing; (2) an image sensor encased in the housing and configured to capture activity of the smart home environment; (3) a wireless radio configured to transmit video frames captured by the image sensor to an electronic device via a remote server; (4) at least one infrared transmitter configured to selectively illuminate the smart home environment; (5) one or more circuit boards encased in the housing, the one or more circuit boards including at least one processor mounted thereon; and (6) a heating component coupled to the image sensor, the heating component configured to continuously maintain the image sensor at a temperature above a threshold temperature while the image sensor is capturing the activity of the smart home environment.

Abstract: The present invention relates to a polynucleotide comprising a Nuclear factor of activated T-cells (NFAT) binding site sequence and a reverse complement of said NFAT binding site sequence separated by a spacer sequence, to said polynucleotide for use in treating and/or preventing disease, and to viral particles, compositions, and uses related thereto. The present invention further relates to a polynucleotide comprising a Nuclear factor of activated T-cells (NFAT) binding site sequence and a reverse complement of said NFAT binding site sequence for use in treating and/or preventing an NFAT-mediated disease.

Abstract: The various implementations described herein include a video camera assembly that includes: (1) a housing; (2) an image sensor encased in the housing and configured to capture activity of the smart home environment; (3) a wireless radio configured to transmit video frames captured by the image sensor to an electronic device via a remote server; (4) at least one infrared transmitter configured to selectively illuminate the smart home environment; (5) one or more circuit boards encased in the housing, the one or more circuit boards including at least one processor mounted thereon; and (6) a heating component coupled to the image sensor, the heating component configured to continuously maintain the image sensor at a temperature above a threshold temperature while the image sensor is capturing the activity of the smart home environment.

Abstract: In order to prevent slices separated from a product caliber by a slicer from adhering temporarily to a cutting surface of a blade and not coming to rest on the desired position on a base when the slices are ejected, the arrangement of one or more recesses in the blade back facing away from the product caliber is suggested in a specific way.

Abstract: An attachment mechanism for mounting an electronic device to a surface including a mounting plate configured to attach to the surface, the mounting plate having at least one projection, and a base configured to releasably couple to the mounting plate. The base may include a first biasing member, and a first arm pivotably coupled to the base and biased toward a first direction by the first biasing member, the first arm configured to interlock with the at least one projection when the base is coupled to the mounting plate. The base may further include a release mechanism coupled to the first arm such that actuation of the release mechanism when the base is coupled to the mounting plate in a secured engagement causes movement of the first arm in a second direction to disengage the first arm from the at least one projection to enable detachment of the base from the mounting plate.

Abstract: A hinge for an electronic device includes a base including a stem, a ball rigidly fixed to the stem, a first friction surface that contacts and is configured to move with respect to a first outer surface of the ball, a second friction surface that contacts and is configured to move with respect to a second outer surface of the ball, the second outer surface of the ball being on a side of the ball that is opposite the first outer surface of the ball, and a biasing member configured to bias the first and/or second friction surface against the ball to generate a frictional force sufficient to hold the first and second friction surfaces in a set position relative to the ball.

Abstract: The present invention relates to an antagonist of the Two-Pore Domain Potassium Channel (TASK-1) K2P3.1 for use in the prevention and/or treatment of cardiac arrhythmia in a subject. The invention also relates to a nucleic acid molecule usable in the prevention and/or treatment of cardiac arrhythmia in a subject. The invention further relates to a cell comprising said nucleic acid molecule. The invention further relates to a vector comprising said nucleic acid molecule.

Abstract: A method for evaluating measurement data from a measurement of a plurality of workpieces includes obtaining a set of measurement data. Each workpiece has an associated set of measurement data. The set of measurement data corresponds to measurement points of the workpieces. The set of measurement data has, for each measurement point of the workpieces, at least one measured coordinate and/or, for each measured coordinate, a divergence from a comparison coordinate. The method includes determining a measure of the correlation of the measured coordinates and/or of the divergences is determined for a plurality of the sets of measurement data, in each case in relation to a pair of measurement points that consists of two measurement points of the workpieces.

Abstract: The various implementations described herein include a video camera assembly that includes: (1) a housing; (2) an image sensor positioned within the housing and having a field of view corresponding to a scene in the smart home environment; and (3) a concave-shaped front face positioned in front of the image sensor such that light from the scene passes through the front face prior to entering the image sensor; where the front face includes: (a) an inner section corresponding to the image sensor; and (b) an outer section between the housing and the inner section, the outer section having a concave shape that extends from an outer periphery of the outer section to an inner periphery of the outer section; and where the concave shape extends around an entirety of the outer periphery.