Abstract: The present invention relates to biomarkers and biomarker panels useful in the prognosis and diagnosis of cancers, in particular epithelial cancers. The present invention also provides methods of treatment of patients diagnosed or having undergone diagnosis or prognosis using the biomarkers and biomarker panels of the invention. Kits for the analysis of the biomarkers and biomarker panels are also provided. The biomarker panel consists of COL11A1, CTS, ANXA6, LGALS3, ANXA1, AB13BP, COMP, COL1A1, LAMB1, CTSG, LAMA4, TNXB, FN1, AGT, FBLN2, HSPG2, COL6A6, VCAN, ANXA5, LAMC1, COL15A1 and VWF.

Abstract: There is disclosed a connector, such as a wet-mateable connector, comprising first and second components having first and second contacts respectively and arranged to be coupled together such that the first and second contacts make a connection. The connector comprises a shuttle associated with the first component and moveable between at least a decoupled position in which the shuttle protects the first contact and a coupled position in which the first contact is exposed. During coupling of the first and second components the shuttle is moved to the coupled position so as to expose the first contact such that it can make an electrical connection with the second contact. The connector also comprises a latch arranged to latch the second component to the shuttle such that upon decoupling of the first and second components, the shuttle is returned to the decoupled position.

Abstract: There is disclosed a connector, such as a wet-mateable connector, comprising first and second components having first and second contacts respectively and arranged to be coupled together such that the first and second contacts make a connection. The connector comprises a shuttle associated with the first component and moveable between at least a decoupled position in which the shuttle protects the first contact and a coupled position in which the first contact is exposed. During coupling of the first and second components the shuttle is moved to the coupled position so as to expose the first contact such that it can make an electrical connection with the second contact. The connector also comprises a latch arranged to latch the second component to the shuttle such that upon decoupling of the first and second components, the shuttle is returned to the decoupled position.