Patents by Inventor Oliver RAMMO

Oliver RAMMO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR TARGET RELEASE FROM INTEIN COMPLEXES
    Publication number: 20230391821
    Abstract: The present disclosure relates to methods of releasing a target molecule from intein complexes comprising an intein-C tagged target molecule and intein-N polypeptides, by contacting the intein complexes with nitrogen containing heteroaromatic derivatives, and/or by increasing residence time of intein complexes in a medium effective to remove the target molecule. Modulating the pH further facilitates target release.
    Type: Application
    Filed: September 27, 2021
    Publication date: December 7, 2023
    Applicant: MERCK PATENT GMBH
    Inventors: Oliver RAMMO, Vanessa KOHL
  • REUSE OF INTEIN-BOUND RESINS FOR PROTEIN PURIFICATION
    Publication number: 20230064395
    Abstract: The present disclosure relates to methods of protein purification by attaching an intein-C fragment to a target protein, passing a sample containing the intein-C tagged protein over a chromatographic resin carrying an intein-N fragment so as to create an intein-N intein-C complex, releasing the target protein from the intein-C fragment, and regenerating the column under conditions that disrupt the intein-N intein-C complex while preserving column functionality for multiple reuses.
    Type: Application
    Filed: March 23, 2021
    Publication date: March 2, 2023
    Applicant: Merck Patent GmbH
    Inventors: Oliver RAMMO, Romas SKUDAS