Patents by Inventor Oliver Rando

Oliver Rando has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS OF DELIVERING SMALL RNAS TO SPERM
    Publication number: 20220307025
    Abstract: Methods and compositions directed to altering a population of sRNAs in a sperm using vesicles isolated from an epididymosome are provided. Methods and compositions directed to altering a population of sRNAs in an oocyte using vesicles isolated from an epididymosome are also provided. Methods for altering an sRNA population in a sperm or an oocyte can be used to prevent, or reduce the severity of, a disease, disorder, or condition that would otherwise be inherited by progeny. For example, certain epigenetic inherited conditions due to paternal effects, such as certain metabolic and stress disorders and conditions, can be ameliorated in progeny using sperm or oocytes having an altered sRNA population.
    Type: Application
    Filed: March 3, 2022
    Publication date: September 29, 2022
    Inventors: Oliver RANDO, Upasna SHARMA, Colin CONINE
  • Process of delivering small RNAs to sperm
    Patent number: 11299733
    Abstract: Methods and compositions directed to altering a population of sRNAs in a sperm using vesicles isolated from an epididymosome are provided. Methods and compositions directed to altering a population of sRNAs in an oocyte using vesicles isolated from an epididymosome are also provided. Methods for altering an sRNA population in a sperm or an oocyte can be used to prevent, or reduce the severity of, a disease, disorder, or condition that would otherwise be inherited by progeny. For example, certain epigenetic inherited conditions due to paternal effects, such as certain metabolic and stress disorders and conditions, can be ameliorated in progeny using sperm or oocytes having an altered sRNA population.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: April 12, 2022
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Oliver Rando, Upasna Sharma, Colin Conine
  • PROCESS OF DELIVERING SMALL RNAS TO SPERM
    Publication number: 20190309294
    Abstract: Methods and compositions directed to altering a population of sRNAs in a sperm using vesicles isolated from an epididymosome are provided. Methods and compositions directed to altering a population of sRNAs in an oocyte using vesicles isolated from an epididymosome are also provided. Methods for altering an sRNA population in a sperm or an oocyte can be used to prevent, or reduce the severity of, a disease, disorder, or condition that would otherwise be inherited by progeny. For example, certain epigenetic inherited conditions due to paternal effects, such as certain metabolic and stress disorders and conditions, can be ameliorated in progeny using sperm or oocytes having an altered sRNA population.
    Type: Application
    Filed: July 12, 2017
    Publication date: October 10, 2019
    Inventors: Oliver RANDO, Upasna SHARMA, Colin CONINE
  • Proteasome regulation of NF-kB activity
    Publication number: 20040097420
    Abstract: Disclosed herein is a method for regulating the activity of NF-&kgr;B in an animal comprising contacting cells of the animal with certain proteasome inhibitors.
    Type: Application
    Filed: January 28, 2003
    Publication date: May 20, 2004
    Applicant: Harvard College
    Inventors: Vito J. Palombella, Alfred L. Goldberg, Thomas P. Maniatis, Oliver Rando
  • Proteasome regulation of NF-KB activity
    Patent number: 6660268
    Abstract: Disclosed herein is a method for regulating the activity of NF-&kgr;B in an animal comprising contacting cells of the animal with certain proteasome inhibitors.
    Type: Grant
    Filed: March 18, 1994
    Date of Patent: December 9, 2003
    Assignee: The President and Fellows of Harvard College
    Inventors: Vito J. Palombella, Alfred L. Goldberg, Thomas P. Maniatis, Oliver Rando