Abstract: Provided are chemical entities selected from compounds of formula (I), wherein R1, R2 and m have meanings given in the description, and pharmaceutically acceptable salts, solvates and stereoisomers thereof, which are inhibitors of ATR and are potentially useful in the treatment of cancer. Further provided are pharmaceutical compositions of the chemical entities, combination products containing the chemical entities, the use of the compositions as therapeutic agents, and methods of treatment using these compositions.

Abstract: Provided are chemical entities selected from compounds of formula (I), wherein R1, R2 and m have meanings given in the description, and pharmaceutically acceptable salts, solvates and stereoisomers thereof, which are inhibitors of ATR and are potentially useful in the treatment of cancer. Further provided are pharmaceutical compositions of the chemical entities, combination products containing the chemical entities, the use of the compositions as therapeutic agents, and methods of treatment using these compositions.

Abstract: A detent mount bracket for an adjusting device in a motor vehicle seat includes first and second hinge parts that are adjustable with respect to each other about a hinge axis. A stopper part is slidably disposed between a detent position and a release position on the first hinge part, and comprises an outer toothed surface and a first control region. An adjusting part is connected to a shaft and comprises a second control region cooperating with the first control region. An elastic means biases the stopper part in the detent position. On the second hinge part defines an inner toothed surface, which mates with the outer toothed surface. The stopper part is axially slidably disposed on the first hinge part, is substantially non-rotatably disposed, and is spaced an additional axial distance apart from the first hinge part in the detent position than in the release position.