Abstract: A method for operating a railway system. Cryptographic data which includes at least one key and/or at least one digital certificate is stored in a storage device of a vehicle of the railway system. The vehicle transmits the cryptographic data to at least one track-side device of the railway system when the vehicle is in communication range of the least one track-side device as part of the train travel. There is also described a corresponding rail vehicle of a railway system.

Abstract: Gelsolin inhibitors are provided for use in treating diseases such as infectious diseases and cancer. Prognostic methods and methods for screening for gelsolin inhibitors are also provided.

Abstract: A medical instrument includes a first hand lever which has a manually actuated grip portion at its proximal end, a work portion for gripping, clamping or cutting an object at its distal end, and, lying between these, a bearing portion on which a bearing element engages in order to permit pivotability about a rotation axis between the first hand lever and a second hand lever, wherein the second hand lever has a grip portion at its proximal end, a work portion at its distal end, and, lying between these, a guide portion on which the bearing element engages, wherein the guide portion of the second hand lever has on one side a recess for receiving the bearing portion of the first hand lever such that two guide protrusions located distally and proximally of the recess at least partially cover the bearing portion in an operating position.

Abstract: A multifunctional steering column for a transportation vehicle having a steering bracket for connection of the steering column to a transportation vehicle body of the transportation vehicle; a steering tube held on the steering bracket and which has a steering tube axis; a steering wheel connection for mechanical coupling of the steering column to a steering wheel; and a steering gear end at which a steering gear clutch with a steering gear connection for mechanical coupling to a steering gear of the transportation vehicle is arranged. Also disclosed is a transportation vehicle and a method for operating a transportation vehicle.

Abstract: A medical instrument includes a first hand lever which has a manually actuated grip portion at its proximal end, a work portion for gripping, clamping or cutting an object at its distal end, and, lying between these, a bearing portion on which a bearing element engages in order to permit pivotability about a rotation axis between the first hand lever and a second hand lever, wherein the second hand lever has a grip portion at its proximal end a work portion at its distal end, and lying between these, a guide portion on which the bearing element engages, wherein the guide portion of the second hand lever has on one side a recess for receiving the bearing portion of the first hand lever such that two guide protrusions located distally and proximally of the recess at least partially cover the bearing portion in an operating position.

Abstract: A method for operating a railway system. Cryptographic data which includes at least one key and/or at least one digital certificate is stored in a storage device of a vehicle of the railway system. The vehicle transmits the cryptographic data to at least one track-side device of the railway system when the vehicle is in communication range of the least one track-side device as part of the train travel. There is also described a corresponding rail vehicle of a railway system.

Abstract: A multifunctional steering column for a transportation vehicle having a steering bracket for connection of the steering column to a transportation vehicle body of the transportation vehicle; a steering tube held on the steering bracket and which has a steering tube axis; a steering wheel connection for mechanical coupling of the steering column to a steering wheel; and a steering gear end at which a steering gear coupling with a steering gear connection for mechanical coupling to a steering gear of the transportation vehicle is arranged. Also disclosed is a transportation vehicle and a method for operating a transportation vehicle.

Abstract: The invention relates to an extracorporeal blood treatment machine, such as a dialysis machine, comprising leakage detection as well as to a method of detecting leakages in the dialysis fluid circuit of a dialysis machine, wherein at least part of the dialysis fluid system to be monitored in terms of leakage is accommodated in a hermetically sealed housing and the housing is or can be ventilated in a controlled manner, and wherein a parameter, such as the air humidity of the air flowing into the housing is compared to a corresponding parameter, preferably air humidity of the air flowing out of the housing.

Abstract: The invention relates to an extracorporeal blood treatment machine, such as a dialysis machine, comprising leakage detection as well as to a method of detecting leakages in the dialysis fluid circuit of a dialysis machine, wherein at least part of the dialysis fluid system to be monitored in terms of leakage is accommodated in a hermetically sealed housing and the housing is or can be ventilated in a controlled manner, and wherein a parameter, such as the air humidity of the air flowing into the housing is compared to a corresponding parameter, preferably air humidity of the air flowing out of the housing.

Abstract: The invention relates to an extracorporeal blood treatment machine, such as a dialysis machine, comprising leakage detection as well as to a method of detecting leakages in the dialysis fluid circuit of a dialysis machine, wherein at least part of the dialysis fluid system to be monitored in terms of leakage is accommodated in a hermetically sealed housing and the housing is or can be ventilated in a controlled manner, and wherein a parameter, such as the air humidity of the air flowing into the housing is compared to a corresponding parameter, preferably air humidity of the air flowing out of the housing.

Abstract: A method for controlling a pressure (32, 34) in an injection system (14) for an engine (12) of a vehicle (10) comprises the following steps: determining whether the vehicle (10) is decelerating; reducing the delivery rate of a high-pressure pump (16) that supplies fuel to the injection system (14); reducing the pressure in the injection system (14) to a standstill pressure (ps) by means of idle operation of the engine (12); estimating a standstill time (t1) at which the vehicle (10) comes to a standstill; and reducing the delivery rate of the high-pressure pump (16) before the standstill time (t1) is reached, such that the standstill pressure (ps) is attained in the injection system (14) at the standstill time (t1).

Abstract: A method for controlling a pressure (32, 34) in an injection system (14) for an engine (12) of a vehicle (10) comprises the following steps: determining whether the vehicle (10) is decelerating; reducing the delivery rate of a high-pressure pump (16) that supplies fuel to the injection system (14); reducing the pressure in the injection system (14) to a standstill pressure (pS) by means of idle operation of the engine (12); estimating a standstill time (t1) at which the vehicle (10) comes to a standstill; and reducing the delivery rate of the high-pressure pump (16) before the standstill time (t1) is reached, such that the standstill pressure (pS) is attained in the injection system (14) at the standstill time (t1).

Abstract: The invention relates to the regulation of the immune system, and in particular to the finding that the CLEC9a molecule is a marker for dendritic cells which are capable of cross-presenting extracellular antigens via the MHC class I pathway. This makes them particularly suitable for generation of cytotoxic T lymphocyte responses. Materials and methods are provided both for the induction of immune responses against target antigens, and for the inhibition or suppression of undesirable immune responses in which these cells are involved.

Abstract: The invention relates to an extracorporeal blood treatment machine, such as a dialysis machine, comprising leakage detection as well as to a method of detecting leakages in the dialysis fluid circuit of a dialysis machine, wherein at least part of the dialysis fluid system to be monitored in terms of leakage is accommodated in a hermetically sealed housing and the housing is or can be ventilated in a controlled manner, and wherein a parameter, such as the air humidity of the air flowing into the housing is compared to a corresponding parameter, preferably air humidity of the air flowing out of the housing.

Abstract: The invention relates to the regulation of the immune system, and in particular to the finding that the CLEC9a molecule is a marker for dendritic cells which are capable of cross-presenting extracellular antigens via the MHC class I pathway. This makes them particularly suitable for generation of cytotoxic T lymphocyte responses. Materials and methods are provided both for the induction of immune responses against target antigens, and for the inhibition or suppression of undesirable immune responses in which these cells are involved.

Abstract: The invention relates to the regulation of the immune system, and in particular to the finding that the CLEC9a molecule is a marker for dendritic cells which are capable of cross-presenting extracellular antigens via the MHC class I pathway. This makes them particularly suitable for generation of cytotoxic T lymphocyte responses. Materials and methods are provided both for the induction of immune responses against target antigens, and for the inhibition or suppression of undesirable immune responses in which these cells are involved.

Abstract: The invention relates to the regulation of the immune system, and in particular to the finding that the CLEC9a molecule is a marker for dendritic cells which are capable of cross-presenting extracellular antigens via the MHC class I pathway. This makes them particularly suitable for generation of cytotoxic T lymphocyte responses. Materials and methods are provided both for the induction of immune responses against target antigens, and for the inhibition or suppression of undesirable immune responses in which these cells are involved.

Abstract: A method and a device for exciting pressure fluctuations in a fuel supply system of an internal combustion engine are provided, which in turn enable a determination of the sound velocity of the fuel. A quantity that characterizes the pressure in a fuel storage device or a fuel line is evaluated. In at least one operating state of the internal combustion engine, a natural oscillation of the fuel in the fuel storage device or the fuel line is excited.

Abstract: A device and a method for determining pressure fluctuations in a fuel supply system provide two signal filters to enable determining as much information about pressure fluctuations as possible with minimal sensor use. A sensor signal which is characteristic of a pressure in the area of a fuel injector is filtered using the two filters, which have filter characteristics that differ from one another.

Abstract: A method and a device for exciting pressure fluctuations in a fuel supply system of an internal combustion engine are provided, which in turn enable a determination of the sound velocity of the fuel. A quantity that characterizes the pressure in a fuel storage device or a fuel line is evaluated. In at least one operating state of the internal combustion engine, a natural oscillation of the fuel in the fuel storage device or the fuel line is excited.