Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

Abstract: An asymmetric membrane. The asymmetric membrane includes a membrane wall with a first and a second porous surface and an interior situated between the surfaces; a first asymmetrical region towards the first surface; a second asymmetrical region towards the second surface; wherein the asymmetric membrane is made from a polymeric blend comprising an aromatic sulfone polymer and poly (2-oxazoline); and wherein the asymmetric membrane is in the form of a flat sheet.

Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 102, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.

Abstract: A method of treating a metastatic lesion that presents a peptide containing SLLQHLIGL (SEQ ID NO: 310) on a cell surface, including selecting a patient having a metastatic lesion and administering to the patient a composition containing recombinant T lymphocytes or activated T lymphocytes that express a T cell receptor, or a functional fragment thereof, that is reactive with, or binds to, an MHC ligand containing SLLQHLIGL (SEQ ID NO: 310).

Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 102, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO:1 to SEQ ID NO:113, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.

Abstract: A polymeric membrane. The membrane can include a polymeric membrane made from a polymer selected from an aromatic sulfone polymer, polyamide, cellulose, cellulose acetate, polymethylmethacrylate, polyvinylalcohol, and polyacrylnitril, wherein the polymeric membrane has a major surface; a stilbenoid, isoflavone or flavone coated on the major surface of the polymeric membrane.

Abstract: Hydrophobic flat membrane made from a vinylidene fluoride polymer with a wall, a first surface, and a second surface. The membrane has on its first surface a network structure with open pores and on its second surface a continuous skin in which pores are formed, and adjacent to the skin of the second surface a supporting layer with an isotropic pore structure across the wall thickness, wherein the supporting layer extends over at least 80% of the wall thickness and wherein the pores of the supporting layer have an average diameter of less than 1 ?m. The weight average of the molecular weight MW of the vinylidene fluoride polymer lies in the range from 300 000 to 500 000 daltons, and the polydispersivity MW/MN is greater than 5.5. The pores in the skin of the second surface have a closed perimeter in the plane of the skin and an average ratio of the extension in the direction of the longest axis thereof to the extension in the direction of the shortest axis thereof of at most 5.

Abstract: Hydrophobic hollow-fiber membrane made from a vinylidene fluoride polymer with a wall and a wall thickness, an outer surface on its outer side, an inner surface on its inner side and facing its lumen and adjacent to the inner surface a supporting layer having a structure that is substantially isotropic across the wall thickness, the supporting layer extending over at least 80% of the wall thickness and comprising pores having an average diameter of less than 1 ?m, and wherein the hollow-fiber membrane has pores on its outer surface and on its inner surface, characterized in that the vinylidene fluoride polymer has a weight-average molecular weight MW in the range from 550 000 to 700 000 daltons and a polydispersivity greater than 3.0; the pores in the outer and in the inner surface are formed like islands and have a maximum ratio of their longitudinal extension to the transverse extension of 10; the porosity lies in the range from 50 to 90 vol.

Abstract: A catalyst system for the polymerization of olefins may include a first solid catalytic component and a second solid catalytic component. The first solid catalytic component may include: a spherical MgCl2-xROH support; a group 4-8 transition metal; and a diether internal electron donor. The second solid catalytic component may include: a spherical MgCl2-xROH support; a group 4-8 transition metal; and a diether internal electron donor. The first solid catalytic component produces a propylene homopolymer having a Xylene Solubles (XS) value of greater than 2 wt %; and the second solid catalytic component produces a propylene homopolymer having a XS value of less than 2 wt %. The second catalytic component may act as an external electron donor during use, and embodiments herein do not require use of any additional external electron donors to control polymerization and reliably vary the properties of the resulting polymer.

Abstract: Improved Ziegler-Natta catalysts and methods of making the improved catalyst are described. The Ziegler-Natta catalyst is formed using a spherical MgCl2-xROH support, where R is a linear, cyclic or branched hydrocarbon unit with 1-10 carbon atoms and where ROH is an alcohol or a mixture of at least two different alcohols and where x has a range of about 1.5 to 6.0, preferably about 2.5 to 4, more preferably about 2.9 to 3.4, and even more preferably 2.95 to 3.35. The Ziegler-Natta catalyst includes a Group 4-8 transition metal and an internal donor comprising a diether compound. The catalyst has improved activity in olefin polymerization reactions as well as good stereoregularity and hydrogen sensitivity, and may be useful in the production of phthalate-free propylene polymers having a molecular weight distribution (PI(GPC)) in the range from about 5.75 to about 9.

Abstract: A method for making a solid catalyst component for use in a Ziegler-Natta catalyst includes combining in a hydrocarbon solvent a porous particulate support with a hydrocarbon soluble organomagnesium compound to form a suspension. The organomagnesium compound is halogenated followed by addition of an alcohol and the mixture is then reacted with a titanium compound followed by a reaction with at least one diether compound to form the solid catalyst component. Afterwards the reaction product is extracted with a mixture of a titanium compound and a hydrocarbon solvent. The solid catalyst component recovered is combined with an aluminum cocatalyst to form a Ziegler-Natta catalyst system for the polymerization of olefins. In particular, the catalyst system including a diether internal electron donor may have an activity and hydrogen response suitable for the production of propylene polymers having a molecular weight distribution (PI(GPC)) in the range from about 5.75 to about 9.

Abstract: Hydrophobic flat membrane made from a vinylidene fluoride polymer with a wall, a first surface, and a second surface. The membrane has on its first surface a network structure with open pores and on its second surface a continuous skin in which pores are formed, and adjacent to the skin of the second surface a supporting layer with an isotropic pore structure across the wall thickness, wherein the supporting layer extends over at least 80% of the wall thickness and wherein the pores of the supporting layer have an average diameter of less than 1 ?m. The weight average of the molecular weight MW of the vinylidene fluoride polymer lies in the range from 300 000 to 500 000 daltons, and the polydispersivity MW/MN is greater than 5.5. The pores in the skin of the second surface have a closed perimeter in the plane of the skin and an average ratio of the extension in the direction of the longest axis thereof to the extension in the direction of the shortest axis thereof of at most 5.

Abstract: A process for the polymerization of propylene is disclosed. The process may include contacting, in a gas phase polymerization reactor, propylene and optionally one or more comonomers with a catalyst system comprising a Ziegler-Natta catalyst and an external electron donor system comprising di(bicyclo[2.2.1]heptan-2-yl)dimethoxysilane.

Abstract: A catalyst system for the polymerization of olefins may include a first solid catalytic component and a second solid catalytic component. The first solid catalytic component may include: a spherical MgCl2-xROH support; a group 4-8 transition metal; and a diether internal electron donor. The second solid catalytic component may include: a spherical MgCl2-xROH support; a group 4-8 transition metal; and a diether internal electron donor. The first solid catalytic component produces a propylene homopolymer having a Xylene Solubles (XS) value of greater than 2 wt %; and the second solid catalytic component produces a propylene homopolymer having a XS value of less than 2 wt %. The second catalytic component may act as an external electron donor during use, and embodiments herein do not require use of any additional external electron donors to control polymerization and reliably vary the properties of the resulting polymer.

Abstract: A catalyst system for the polymerization of olefins may include a first solid catalytic component and a second solid catalytic component. The first solid catalytic component may include: a spherical MgCl2-xROH support; a group 4-8 transition metal; and a diether internal electron donor. The second solid catalytic component may include: a spherical MgCl2-xROH support; a group 4-8 transition metal; and a diether internal electron donor. The first solid catalytic component produces a propylene homopolymer having a Xylene Solubles (XS) value of greater than 2 wt %; and the second solid catalytic component produces a propylene homopolymer having a XS value of less than 2 wt %. The second catalytic component may act as an external electron donor during use, and embodiments herein do not require use of any additional external electron donors to control polymerization and reliably vary the properties of the resulting polymer.

Abstract: A method for making a solid catalyst component for use in a Ziegler-Natta catalyst includes combining in a hydrocarbon solvent a porous particulate support with a hydrocarbon soluble organomagnesium compound to form a suspension. The organomagnesium compound is halogenated followed by addition of an alcohol and the mixture is then reacted with a titanium compound followed by a reaction with at least one diether compound to form the solid catalyst component. Afterwards the reaction product is extracted with a mixture of a titanium compound and a hydrocarbon solvent. The solid catalyst component recovered is combined with an aluminum cocatalyst to form a Ziegler-Natta catalyst system for the polymerization of olefins. In particular, the catalyst system including a diether internal electron donor may have an activity and hydrogen response suitable for the production of propylene polymers having a molecular weight distribution (PI(GPC)) in the range from about 5.75 to about 9.

Abstract: Improved Ziegler-Natta catalysts and methods of making the improved catalyst are described. The Ziegler-Natta catalyst is formed using a spherical MgCl2-xROH support, where R is a linear, cyclic or branched hydrocarbon unit with 1-10 carbon atoms and where ROH is an alcohol or a mixture of at least two different alcohols and where x has a range of about 1.5 to 6.0, preferably about 2.5 to 4, more preferably about 2.9 to 3.4, and even more preferably 2.95 to 3.35. The Ziegler-Natta catalyst includes a Group 4-8 transition metal and an internal donor comprising a diether compound. The catalyst has improved activity in olefin polymerization reactions as well as good stereoregularity and hydrogen sensitivity, and may be useful in the production of phthalate-free propylene polymers having a molecular weight distribution (PI(GPC)) in the range from about 5.75 to about 9.