Abstract: The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.

Abstract: Various implementations disclosed herein include devices, systems, and methods for normal estimation using a directional measurement, such as a gravity vector. In various implementations, a device includes a non-transitory memory and one or more processors coupled with the non-transitory memory. In some implementations, a method includes identifying planar surfaces in an environment represented by an image. Each planar surface is associated with a respective orientation. A directional vector associated with the environment is determined. A subset of the planar surfaces that have a threshold orientation relative to the directional vector is identified. For each planar surface in the subset of the planar surfaces, a normal vector for the planar surface is determined based on the orientation of the planar surface and the directional vector.

Abstract: The present disclosure relates to a spacer for an assembly of a backlight of a display. The disclosure additionally relates to an assembly for a backlight of a display having such a spacer, and to a display having a backlight having such an assembly. The spacer comprises at least one crosspiece. The crosspiece in this case has attachment surfaces for attachment of a first light guide and a second light guide and a receptacle for a sheet stack.

Abstract: A dialysis machine includes a leakage construction having a leakage collecting device and a leakage connector. The leakage connector is preferably a leakage adapter arranged between an opening of the leakage collecting device and a hose. The leakage connector has a main body to which a seal is attached, which can be brought into sealing contact with the leakage collecting device.

Abstract: Various implementations disclosed herein include devices, systems, and methods for pose estimation using one point correspondence, one line correspondence, and a directional measurement. In various implementations, a device includes a non-transitory memory and one or more processors coupled with the non-transitory memory. In some implementations, a method includes obtaining an image corresponding to a physical environment. A first correspondence between a first set of pixels in the image and a spatial point in the physical environment is determined. A second correspondence between a second set of pixels in the image and a spatial line in the physical environment is determined. Pose information is generated as a function of the first correspondence, the second correspondence, and a directional measurement.

Abstract: Various implementations disclosed herein include devices, systems, and methods for normal estimation using a directional measurement, such as a gravity vector. In various implementations, a device includes a non-transitory memory and one or more processors coupled with the non-transitory memory. In some implementations, a method includes identifying planar surfaces in an environment represented by an image. Each planar surface is associated with a respective orientation. A directional vector associated with the environment is determined. A subset of the planar surfaces that have a threshold orientation relative to the directional vector is identified. For each planar surface in the subset of the planar surfaces, a normal vector for the planar surface is determined based on the orientation of the planar surface and the directional vector.

Abstract: In one implementation, a method of estimating the heading of a device is performed by the device including a processor, non-transitory memory, and an image sensor. The method includes determining a geographic location of the device. The method includes capturing, using the image sensor, an image at the geographic location. The method includes detecting one or more lines within the image. The method includes determining a heading of the device based on the one or more lines and the geographic location.

Abstract: The present invention relates to compounds that are IL-17A modulators. The compounds have the structural Formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with modulation of IL-17A activity.

Abstract: Thermoplastic moulding composition consisting of (A) 51 to 69.9 wt % of polyamide elastomer; (B) 15 to 38 wt % of ethylene-?-olefin copolymer; (C) 3 to 25 wt % of polyamide selected from the group consisting of: PA6, PA66, PA6/66, PA610, PA612, PA614, PA616, PA6/610, PA66/610 or mixtures thereof; (D) 0.1 to 2.0 wt % of heat stabilizers based on copper and/or iodide, organic stabilizers or a mixture thereof; (E) 0 to 5.0 wt % of additives, different from (A) to (D); where the sum of (A) to (E) makes 100 wt % of the total moulding composition, and with the proviso that the sum of (B) and (C) is in the range from 30 to 48 wt % based on the total moulding composition.

Abstract: The present invention relates to compounds that are IL-17A modulators. The compounds have the structural Formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with modulation of IL-17A activity.

Abstract: A cooking system is provided. The cooking system includes a housing, a lid, a heating element, a vent tube, and a piston. The housing has a hollow interior. The lid is movable relative to the housing, where the lid and housing cooperate to form a cooking chamber. The heating element is mounted within the lid. The vent tube is arranged within the lid and extends between the cooking chamber and an external environment. The vent tube includes an inlet channel, an outlet channel, and a central channel arranged between the inlet and outlet channel. A piston is arranged within the central channel and configured to alternate between a venting and a non-venting position such that a low-moisture fluid is drawn through the inlet channel into the cooking chamber from the external environment, and a high-moisture fluid is evacuated through the outlet channel into the external environment from the cooking chamber.

Abstract: In one implementation, a method of estimating the heading of a device is performed by the device including a processor, non-transitory memory, and an image sensor. The method includes determining a geographic location of the device. The method includes capturing, using the image sensor, an image at the geographic location. The method includes detecting one or more lines within the image. The method includes determining a heading of the device based on the one or more lines and the geographic location.

Abstract: The present invention relates to medical combination products comprising (i) at least one antibody construct comprising at least one domain which binds to a target antigen expressed on the surface of a cell and at least one other domain which binds to CD3 as well as (ii) at least one molecule that is an antagonist of/an inhibitor of signaling, which is based on an interaction of TNF with its cognate receptor (TNFR), wherein the antagonisation or the inhibition of TNF or its cognate receptor prevents, reduces, or blocks TNF/TNFR mediated signalling. Furthermore, the invention provides therapeutic and preventive methods and medical uses of said combination products, as well as a kit comprising said at least one antibody construct and at least one antagonist/inhibitor of TNF or its cognate receptor, wherein the interaction of said antagonist/inhibitor of TNF with its cognate receptor reduces, mitigates, prevents, or treats cytokine release syndrome.

Abstract: Systems and methods for measuring short wave infrared fluorescence and autofluorescent signals are disclosed. In some embodiments, for example, a method may include exposing a portion of tissue that does not include a fluorescent probe to an excitation source of the tissue, wherein at least a portion of the tissue has an autofluorescence spectrum which includes wavelengths greater than 900 nm, and imaging the tissue with a detector that is sensitive to electromagnetic radiation with wavelengths greater than or equal to 900 nm. In certain other embodiments, a system comprises a fluorescent probe including a fluorescent component attached to a carrier, an excitation source, and a detector that detects a tail portion of the fluorescence of the fluorescent component. Methods associated with such a system are also disclosed.

Abstract: Various implementations disclosed herein include devices, systems, and methods for normal estimation using a directional measurement, such as a gravity vector. In various implementations, a device includes a non-transitory memory and one or more processors coupled with the non-transitory memory. In some implementations, a method includes identifying planar surfaces in an environment represented by an image. Each planar surface is associated with a respective orientation. A directional vector associated with the environment is determined. A subset of the planar surfaces that have a threshold orientation relative to the directional vector is identified. For each planar surface in the subset of the planar surfaces, a normal vector for the planar surface is determined based on the orientation of the planar surface and the directional vector.

Abstract: An example method includes obtaining user consent to collect and make use of personal information for providing behavioral coaching; obtaining contextual and fitness related information of a user; determining, by inputting the contextual and fitness related information into a model that defines a motivational state, a current motivational state of the user; determining, based at least in part on the current motivational state of the user, a type of information to output as part of the behavioral coaching, wherein the type of information is selected from a group comprising education information, inspirational information, and achievement information; determining, based on the type of information to output, a channel for outputting the type of information as part of the behavioral coaching; and outputting, by the computing device, via the channel, a notification including content of the type of information.

Abstract: A cooking system is provided. The cooking system includes a housing, a lid, a heating element, a vent tube, and a piston. The housing has a hollow interior. The lid is movable relative to the housing, where the lid and housing cooperate to form a cooking chamber. The heating element is mounted within the lid. The vent tube is arranged within the lid and extends between the cooking chamber and an external environment. The vent tube includes an inlet channel, an outlet channel, and a central channel arranged between the inlet and outlet channel. A piston is arranged within the central channel and configured to alternate between a venting and a non-venting position such that a low-moisture fluid is drawn through the inlet channel into the cooking chamber from the external environment, and a high-moisture fluid is evacuated through the outlet channel into the external environment from the cooking chamber.

Abstract: In some implementations, a method includes: extracting key-points from a reference image associated with a scene; generating a multi-cone structure including cones based on the key-points and intrinsic parameters, wherein an apex of the cones corresponds to a camera origin point associated with the reference image, and wherein each axis of the cones intersects a respective key-point; aligning the multi-cone structure based on a nominal alignment vector in order to restrict two rotational degrees of freedom; and determining a rigid transformation for the multi-cone structure, including a value for a remaining rotational degree of freedom and values for three translational degrees of freedom, within a search space associated with the scene, wherein a number of the cones within the multi-cone structure that include at least one point in a three-dimensional (3D) point cloud associated with the scene is maximal when the multi-cone structure is transformed by the rigid transformation.

Abstract: An advanced data platform may receive an asset pricing request containing information about an asset. An optimization engine may determine a predicted price for the asset at different locations and times and compute a price matrix accordingly. The engine may identify an optimized predicted price from the price matrix, taking into account the spatial and temporal factors and various optimization conditions. A view for presentation of the optimized predicted price for the asset on a client device is generated and communicated to the client device over a network. When the asset is a vehicle, the engine may compute a linear regression model that defines a set of input variables with associated regression coefficients, the set of input variables comprising input variables representing attributes describing the vehicle.

Abstract: Various implementations disclosed herein include devices, systems, and methods for pose estimation using one point correspondence, one line correspondence, and a directional measurement. In various implementations, a device includes a non-transitory memory and one or more processors coupled with the non-transitory memory. In some implementations, a method includes obtaining an image corresponding to a physical environment. A first correspondence between a first set of pixels in the image and a spatial point in the physical environment is determined. A second correspondence between a second set of pixels in the image and a spatial line in the physical environment is determined. Pose information is generated as a function of the first correspondence, the second correspondence, and a directional measurement.