Abstract: Methods for determining a disease condition of a subject of a species are provided that comprises obtaining a dataset of fragment methylation patterns determined by methylation sequencing of nucleic acid from a biological sample of the subject. A fragment methylation pattern comprises the methylation state of each CpG site in the fragment. A patch including a channel comprising parameters for the methylation status of respective CpG sites in a set of CpG sites in a reference genome represented by the patch is constructed by populating, for each respective fragment in the plurality of fragments that aligns to the set of CpG sites, an instance of all or a portion of the plurality of parameters based on the methylation pattern of the respective fragment. Application of the patch to a patch convolutional neural network determines the disease condition of the subject.

Abstract: A multidimensional energy decision system, comprising a plurality of server systems, including at least a statistics server and an interface adapted to receive and send digital information from at least a client system, and further adapted to optionally communicate with the digital exchange via a packet-based data network, wherein the multidimensional energy decision system periodically optimizes operational parameters of client system for a specific time period and a specific energy asset from client system based on forecasted conditions, and directly, or upon decision confirmation from a client system, procures or makes dispatchable energy resources, related externalities, or related derivative financial products, available to a digital exchange or other parties, wherein upon the purchase of a listed asset by another party or across digital exchange, implements dispatch procedures to satisfy the issued contract and, optionally, provides monitoring and verification of performance, is disclosed.

Abstract: A system for single-action energy resource scheduling and participation in energy-related securities, comprising a communications interface executing on a network-connected server and adapted to receive information from a plurality of client user interfaces and a secure action server coupled to the communications interface, wherein the secure action server, on receiving a connection from a client user interface, assigns a unique client identifier to the client user interface and associates the unique identifier with a client account, and wherein the secure action server, on receiving a request from a client user interface, determines whether the client user interface is mapped to an authorized market participant who has enabled single-action scheduling, execution order, or participation confirmation functionality for the client user interface, and passes information to the client user interface pertaining at least to a single action needed to confirm scheduling, execution order, or participation and wherein t

Abstract: A system for presentation and management of energy-related information and securities, comprising a digital exchange, a client system comprising a plurality of display and input modalities, a communications interface software adapted to allow communications between the client system and the digital exchange, and a control interface within the client system adapted to drive the display and input modalities, wherein the control interface, on receiving input from a user, causes data from the digital exchange to be retrieved and displayed in one or more of the display modalities to the user, and upon receipt of a request from the user via an input modality of the client system after the user has retrieved and reviewed data from the digital exchange, an order to execute a transaction is transmitted to the digital exchange by the client system, and on receipt of an order to execute a transaction from a client system, the digital exchange combines the ordered transaction with other similar transactions from a plural