Abstract: Methods for preparing the Bruton's Tyrosine Kinase (“BTK”) inhibitor compound 2-{3?-hydroxymethyl-1-methyl-5-[5-((S)-2-methyl-4-oxetan-3-yl-piperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-[3,4?]bipyridinyl-2?-yl}-7,7-dimethyl-3,4,7,8-tetrahydro-2H,6H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one are provided.

Abstract: A display modification system for use with a display device, including a camera operable to capture images of at least a portion of the display device, an image analysis unit operable to derive the value of one or more parameters associated with the display of images by the display device in dependence upon the captured images, a modification determination unit operable to determine a modification to be applied to a content display process associated with the display device, where the modification includes changes to a content rendering process for generating content to be displayed by the display device and/or one or more display settings associated with the display device, and a modification communication unit operable to transmit information identifying the determined modification to one or both of the display device and a processing device operable to render content for display by the display device.

Abstract: Location mapping and navigation user interfaces may be generated and presented via mobile computing devices. A mobile device may detect its location and orientation using internal systems, and may capture image data using a device camera. The mobile device also may retrieve map information from a map server corresponding to the current location of the device. Using the image data captured at the device, the current location data, and the corresponding local map information, the mobile device may determine or update a current orientation reading for the device. Location errors and updated location data also may be determined for the device, and a map user interface may be generated and displayed on the mobile device using the updated device orientation and/or location data.

Abstract: DMA architectures capable of performing multi-level multi-striding and determining multiple memory addresses in parallel are described. In one aspect, a DMA system includes one or more hardware DMA threads. Each DMA thread includes a request generator configured to generate, during each parallel memory address computation cycle, m memory addresses for a multi-dimensional tensor in parallel and, for each memory address, a respective request for a memory system to perform a memory operation. The request generator includes m memory address units that each include a step tracker configured to generate, for each dimension of the tensor, a respective step index value for the dimension and, based on the respective step index value, a respective stride offset value for the dimension. Each memory address unit includes a memory address computation element configured to generate a memory address for a tensor element and transmit the request to perform the memory operation.

Abstract: A chromatography system for at least one of tangential flow chromatography and lateral flow chromatography comprising: an inlet; a functionalised adsorbent chromatography medium downstream of the inlet; an outlet downstream of the adsorbent chromatography medium; and a flow guide downstream of the inlet and upstream of the adsorbent chromatography medium and configured to distribute a flow of a liquid from the inlet across a width of the adsorbent chromatography medium; wherein the flow guide comprises a pattern of channels providing flow paths from the inlet to different parts of the adsorbent chromatography medium along the width of the adsorbent chromatography medium, wherein the pattern of channels is provided so as to reduce a difference in arrival time and/or flow velocity of liquid reaching the adsorbent chromatography medium across the width of the adsorbent chromatography medium.

Abstract: An apparatus for fluid delivery in oral irrigation comprises a fluid delivery tube with a proximal end and a distal end. The proximal end is configured to receive fluid for oral irrigation. A nozzle is placed at the distal end of the fluid delivery system and a mechanical valve is placed at the nozzle. The mechanical valve is closed in equilibrium and is configured to open when a force is applied to the mechanical valve by each of two neighboring teeth.

Abstract: A computer-implemented recommendation system is for recommending a type of oral care accessory to be used with an oral care device. The recommendation takes account of oral geometry information in respect of a user and preferably also user behavioral information in respect of the manner in which the particular user conducts their oral care using the oral care device. The recommendation is based on the modelling of mechanical interactions between one or more oral care accessories of a set of oral care accessories and the oral geometry of the user when the user performs an oral care routine. From said modelling a cleaning metric is determined that represents the effectiveness of the oral care routine when using said one or more oral care accessories.

Abstract: An offset-angle extension device for a power tool includes an elongated body having a power tool mounting end and an angle adapter end. A bearing housing with a handle is located between and connected to the power tool mounting end and the angle adapter end. The bearing housing includes a bearing that receives a bit extension rod therethrough. A tool mounting rod extends from the bearing housing to the power tool mounting end and connects to the power tool. The bit extension rod extends from a chuck of the power tool, through the bearing and connects to an offset-angle angle adapter.

Abstract: A method and apparatus for manufacturing a part. The part is designed using a CAD system to generate a CAD part model of the part. Features of the part are identified from the CAD part model of the part. A parametric specification of the part is generated using the features of the part. The parametric specification of the part is saved as a parametric part model. The parametric part model is used to fabricate the part.

Abstract: Provided is a brush head for an oral cleaning device for cleaning teeth with a combination of brushing and emitting of a cleaning agent. The brush head comprises a bristle set for brushing the teeth and a nozzle for emitting the cleaning agent. When actuating the bristle set from a first configuration, which is optimized for brushing, to a second configuration, which is optimized for emitting of a cleaning agent, at least a part of the bristle 5 set is moved away from the nozzle and/or away from a path of the cleaning agent when being emitted from an orifice of the nozzle.

Abstract: An oral care implement including a handle and an oral care refill head. The handle has a gripping portion, an engagement component coupled to a distal end of the gripping portion, and a stem. The engagement component includes a plate portion and a first engagement feature. The stem extends through an opening in the engagement component and protrudes from the plate portion. The oral care refill head includes an oral care treatment portion and a sleeve portion. The sleeve portion has an inner surface that defines a sleeve cavity having a cavity axis and a second engagement feature. When the oral care refill head is detachably coupled to the handle, the first and second engagement features mate with one another to at least one of: (1) position the oral care refill head and the handle in an operational alignment; and (2) lock the oral care refill head to the handle.

Abstract: An oral care implement including a handle and an oral care refill head. The handle has a gripping portion, an engagement component coupled to a distal end of the gripping portion, and a stem. The engagement component includes a plate portion and a first engagement feature. The stem extends through an opening in the engagement component and protrudes from the plate portion. The oral care refill head includes an oral care treatment portion and a sleeve portion. The sleeve portion has an inner surface that defines a sleeve cavity having a cavity axis and a second engagement feature. When the oral care refill head is detachably coupled to the handle, the first and second engagement features mate with one another to at least one of: (1) position the oral care refill head and the handle in an operational alignment; and (2) lock the oral care refill head to the handle.

Abstract: A power distribution control system for controlling a plurality of power assets connected to a power grid is provided. The system includes a server which can identify a set of power assets selected from sources, loads, and stores that are to form a string and provide to the string instructions for response to a change in the power grid. The system further includes a router for each of the power assets in the string, for receiving instructions from the server and for controlling the respective power asset. The power assets in the string are selected by the server to have different response times and/or response profiles, such that the string of assets present a collective response to the change, the collective response being defined by the server.

Abstract: A cleaning device (10) comprising: a body portion (12); a nozzle member (14) mounted on the body portion and comprising a nozzle head (16), wherein the nozzle member is configured to allow passage of liquid and/or air from a reservoir in the body to the nozzle head; and an orifice (40) in the nozzle head configured to allow the liquid and/or air to exit the nozzle head, wherein the orifice is configured to shape the exiting liquid and/or air into at least one liquid sheet having a length greater than a width at a target cleaning distance.