Abstract: The present invention refers to an in vitro method for the diagnosis and/or prognosis of multiple sclerosis.

Abstract: A computer implemented method of generating graphics video data for a computer game is disclosed. The method comprises receiving, from a remote device (601), first data including image data corresponding to a plurality of pixels of at least one frame of video data of the computer game. Second data, including colour data of a plurality of said pixels, and at least one frame of video data of the computer game based on the first and second data, are generated at a user device (602).

Abstract: Provided herein are specific TRAIL receptor agonist proteins, nucleic acids encoding the same, and methods of treating a subject having a TRAIL-associated disease or disorder. The TRAIL receptor agonist proteins provided herein comprise three soluble TRAIL domains and an Fc fragment. The TRAIL receptor agonist proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

Abstract: A vehicle control system is for a vehicle. The control system has a first control unit configured to determine a manipulated variable of a vehicle actuator of the vehicle and to output same at an actuator interface, a second control unit, which can be connected to a vehicle network and a private network of the vehicle to receive signals that include two or more geometric characteristics and two or more load characteristics of a current vehicle configuration of the vehicle, and a control system network. The second control unit is configured to define a driving dynamics limit value of the current vehicle configuration using the characteristics and to provide the driving dynamics limit value on the control system network. The first control unit is configured to determine the manipulated variable using the driving dynamics limit value.

Abstract: Disclosed herein are methods of administering an inhibitor of the mevalonate pathway with a diet low in cholesterol or lipids. The methods of the present invention can be used to treat conditions such as cancer.

Abstract: An improved method and device for delivering one or more medicinal fluid and/or drug to the body. The device generally comprises an improved autoinjector assembly. The provided improved autoinjector assembly substantially improves injection of one or more medicinal fluid and/or drug to the body.

Abstract: AR glasses comprise a frame with a front frame part (1), mounting means (2, 3, 8) and an optical unit (5). The optical unit (5) is held in the front frame part (1), wherein the optical unit (5) forms a module mountable to the eyeglass frame as a single component. The optical unit (5) comprises at least a display source (56), at least one refractive device, such as triplet lens (54), and a beamsplitter (51, 52). These AR glasses are robust, compact and affordable.

Abstract: The invention provides compounds, compositions and methods for treating medical disorders, such as cancer, an autoimmune disorder, and/or a neurological disorder, and inhibiting LINE1 reverse transcriptase and/or HERV-K reverse transcriptase using a compound according to Formula I or a pharmaceutically acceptable salt thereof, or a related compound provided herein.

Abstract: Provided herein are biosynthetic methods for producing brazzein and related compositions. Uses (e.g., as sweeteners) of the brazzein produced using the methods are also provided.

Abstract: A seal for a vacuum chamber is formed from two outer insulation blocks, an intermediate insulation block, some interior insulation sheets and some exterior insulation sheets. A first outer insulation block seals between a first wall of the vacuum chamber and a first power transmission plate A second outer insulation block seals between a second wall of the vacuum chamber and a second power transmission plate. The intermediate insulation block seals between the first and second power transmission plates. The interior insulation sheets are arranged in slots in a first side of the intermediate insulation block. The exterior insulation sheets are arranged in the slots in a second side of the intermediate insulation block.

Abstract: There is provided a transistor comprising: a graphene layer structure provided on a non-metallic surface of a substrate, the graphene layer structure having an insulating cap; a source contact provided in contact with a first edge of the graphene layer structure; an insulator provided in contact with an opposite, second edge of the graphene layer structure; a drain contact provided in contact with the insulator, whereby there is a distance of least separation between the drain contact and the graphene layer structure along the second edge of the graphene layer structure and through the insulator; and a gate contact provided (i) over the graphene layer structure and separated therefrom by the insulating cap and/or (ii) under the graphene layer structure and separated therefrom by substrate.

Abstract: A handle. The handle can include a main body and a pivoting head having a substantially trapezoidal prism shape and pivotally coupled with the main body about a pivot axis. The pivoting head can have a first end comprising a first limit member and a second end comprising a second limit member, and each of the first and second limit members can include first and second surfaces, the first surface limiting movement of the pivoting head to a first position and the second surface limiting movement of the pivoting head to a second position. A pivot spring can interact with the main body to bias the pivoting head into the first position.

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

Abstract: In some aspects, search functionality is provided in an observability analysis system. In some implementations, search results are obtained from prior search queries, the search results include a subset of event data generated in a computing environment. Metadata are generated by analyzing the event data to identify a plurality of fields and values for each of the plurality of fields. A partial search query is received through a user interface at a first computer node; the partial search query represents at least a portion of a request to search the event data. Autocomplete suggestions are generated at the first computer node based on the partial search query and the metadata. Each of the autocomplete suggestions includes a suggested field selected from the plurality of fields, a suggested value selected from the values, or both. At least one of the autocomplete suggestions is displayed in the user interface.

Abstract: A system for creating a representation of visible space around a machine using a previously determined combined occupancy grid. The system includes a plurality of sensors and an electronic processor. The electronic processor is configured to determine a combined occupancy grid associated with a first time, wherein the combined occupancy grid is determined based on sensor data associated with the first time and received from the plurality of sensors. The electronic processor is also configured to receive, from the plurality of sensors, sensor data associated with a second time and determine a representation of visible space associated with the second time based on the combined occupancy grid associated with the first time and the sensor data associated with the second time. The electronic processor is further configured to control a movement of the machine based on the representation of visible space associated with the second time.

Abstract: A method and apparatus are provided for producing a multicomponent feedstock being delivered through a print head of a 3D printer. Multiple component lengths are produced from separate feedstocks and are aligned to form the multicomponent feedstock which is fed into the print head for extrusion. The method includes providing at least two sources of feedstock of different material, feeding a distal end of a first feedstock along a feed path, cutting the first feedstock at a pre-determined length to provide a length of first feedstock having a proximal end. The method includes feeding a distal end of a second feedstock along the feed path and aligning the distal end of the second feedstock with the proximal end of the length of the first feedstock. The second feedstock is cut at a pre-determined length to provide a length of the second feedstock serially aligned with the length of first feedstock, to form a length of multicomponent feedstock. The length of multicomponent feedstock is fed into the print head.

Abstract: Vaporizer devices are disclosed. In one exemplary embodiment, a vaporizer device can include a vaporizer body including a first airflow path extending at least partially therethrough, and a sensor assembly residing at least partially within the vaporizer body. The sensor assembly includes a flexible sensor that is in communication with the first airflow path. The flexible sensor is configured to reversibly deflect from an initial state to a first state in response to a first user-activated force representing air being drawn through the first airflow path, and configured to reversibly deflect from the initial state to a second state in response to a second user-activated force representing an acceleration of the vaporizer body. Sensor assemblies for a vaporizer device are also provided.

Abstract: Wind turbine cable connector monitoring method and device for monitoring a connector (1) attached to cable (4). A temperature sensor (6) is provided for sensing a measured temperature at a position a known distance along the cable (4) from the connector (1). A controller (8,19) records the measured temperature from the temperature sensor (6) while the connector (4) is in use, and identifies a potential fault condition in the connector (4) based on the measured temperature and the position the known distance along the cable (4) from the connector (1).