Abstract: A glass tube for pharmaceutical containers is provided. The tube has an inner surface at an inner diameter, an outer surface with an outer diameter, a first end defining a first closed end, a second end defining a first closed end, a first location 400 mm from the first end, a first intermediate location 15 mm from the first end, and a ventilation hole at a first vicinity. The first vicinity is between the first intermediate location and the first location. The glass tube can have a ratio of an integrated Na2F+ signal to an integrated 30Si+ signal of at least 0.10, where the integrated Na2F+ signal and the integrated 30Si+ signal are integrated over a depth of 100 nm. The glass tube can have a ratio between a fluorescence emission determined at a first vicinity and a fluorescence emission determined at a middle section of at least 0.6.