Abstract: The present invention relates to photovoltaic lined optical cavity for a robust power generating apparatus consisting of said cavities and manufacturing methods for said cavities. The photovoltaic lined optical cavity comprises of an optical core, a base substrate, photovoltaic layers lining the optical core, and optical elements. The photovoltaic lined optical cavity is optimized for the light capture of solar radiation and sufficient integrity against mechanical loads.

Abstract: The present invention relates to photovoltaic lined optical cavity for a robust power generating apparatus consisting of said cavities and manufacturing methods for said cavities. The photovoltaic lined optical cavity comprises of an optical core, a base substrate, photovoltaic layers lining the optical core, and optical elements. The photovoltaic lined optical cavity is optimized for the light capture of solar radiation and sufficient integrity against mechanical loads.

Abstract: There are provided three-dimensional photovoltaic structures and a power optimizer for a photovoltaic power generation apparatus. The photovoltaic structure may include two or more photovoltaic material face sets including one or more photovoltaic material faces with at least in part in different orientations to each other. In embodiments, each photovoltaic material face may be operatively coupled to power optimizer, for example maximum power point tracking (MPPT) electronics, enabling independent power optimization of the power output of each face.

Abstract: The present invention relates to the field of cell-based therapeutics. Specifically, the invention is concerned with a composition comprising a macrophage overexpressing interleukin 10 (IL-10) from transfected IL-10 encoding mRNA for use as a medicament. Moreover, a method for manufacturing a medicament for treating and/or preventing inflammation or a disease or disorder associated therewith comprising the steps of obtaining a macrophage from a sample of said subject, transfecting mRNA encoding IL-10 into said macrophage, and formulating said macrophage in a composition suitable for administration to the said subject, whereby the medicament is manufactured. Finally, a kit is provided for manufacturing such a medicament.

Abstract: The present invention relates to the field of cell-based therapeutics. Specifically, the invention is concerned with a composition comprising a macrophage overexpressing interleukin 10 (IL-10) from transfected IL-10 encoding mRNA for use as a medicament. Moreover, a method for manufacturing a medicament for treating and/or preventing inflammation or a disease or disorder associated therewith comprising the steps of obtaining a macrophage from a sample of said subject, transfecting mRNA encoding IL-10 into said macrophage, and formulating said macrophage in a composition suitable for administration to the said subject, whereby the medicament is manufactured. Finally, a kit is provided for manufacturing such a medicament.

Abstract: The present invention relates to the field of cell-based therapeutics. Specifically, the invention is concerned with a composition comprising a macrophage overexpressing interleukin 10 (IL-10) from transfected IL-10 encoding mRNA for use as a medicament. Moreover, a method for manufacturing a medicament for treating and/or preventing inflammation or a disease or disorder associated therewith comprising the steps of obtaining a macrophage from a sample of said subject, transfecting mRNA encoding IL-10 into said macrophage, and formulating said macrophage in a composition suitable for administration to the said subject, whereby the medicament is manufactured. Finally, a kit is provided for manufacturing such a medicament.

Abstract: The present invention relates to progenitor cells, medicaments containing progenitor cells and also uses thereof for specific tissue regeneration. Such processes are required in all medical sectors, in particular in the treatment of cardiovascular, haematological, nephrological, neurological, dermatological, gastroenterological or orthopaedic disorders. The progenitor cells are characterized in that they are transfected with mRNA which codes for a protein which promotes colonization of the progenitor cells in a target tissue and/or the differentiation of the progenitor cells in target cells or target tissue cells.