Patents by Inventor Oliver Zoechling

Oliver Zoechling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NUCLEOPHILIC CATALYSTS FOR OXIME LINKAGE
    Publication number: 20210163527
    Abstract: The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime or hydrazone linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer, and wherein the conjugation is carried out in the presence of a nucleophilic catalyst.
    Type: Application
    Filed: February 5, 2021
    Publication date: June 3, 2021
    Inventors: Stefan Haider, Andreas Ivens, Hanspeter Rottensteiner, Jüergen Siekmann, Peter Turecek, Oliver Zoechling
  • NUCLEOPHILIC CATALYSTS FOR OXIME LINKAGE
    Publication number: 20200017543
    Abstract: The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime or hydrazone linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer, and wherein the conjugation is carried out in the presence of a nucleophilic catalyst.
    Type: Application
    Filed: August 5, 2019
    Publication date: January 16, 2020
    Inventors: Stefan Haider, Andreas Ivens, Hanspeter Rottensteiner, Jürgen Siekmann, Peter Turecek, Oliver Zoechling
  • Nucleophilic catalysts for oxime linkage
    Patent number: 10414793
    Abstract: The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime or hydrazone linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer, and wherein the conjugation is carried out in the presence of a nucleophilic catalyst.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: September 17, 2019
    Assignees: Baxalta Incorporated, Baxalta GmbH
    Inventors: Stefan Haider, Andreas Ivens, Hanspeter Rottensteiner, Juergen Siekmann, Peter Turecek, Oliver Zoechling
  • Nucleophilic catalysts for oxime linkage
    Patent number: 8642737
    Abstract: The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime or hydrazone linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer, and wherein the conjugation is carried out in the presence of a nucleophilic catalyst.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: February 4, 2014
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Juergen Siekmann, Stefan Haider, Hanspeter Rottensteiner, Andreas Ivens, Peter Turecek, Oliver Zoechling
  • STABILIZATION OF IMMUNOGLOBULINS AND OTHER PROTEINS THROUGH AQUEOUS FORMULATIONS WITH SODIUM CHLORIDE AT WEAK ACIDIC TO NEUTRAL ph
    Publication number: 20120076779
    Abstract: The present invention provides, among other aspects, storage stabile aqueous formulations of labile proteins at a mildly acidic to neutral pH. The present invention also provides methods for stabilizing a labile therapeutic protein composition at a mildly acidic to neutral pH. Advantageously, the methods and formulations provided herein allow stabile aqueous compositions of labile proteins at mildly acidic to neutral pH useful for parenteral administration.
    Type: Application
    Filed: September 16, 2011
    Publication date: March 29, 2012
    Applicants: Baxter Healthcare S.A., Baxter International Inc.
    Inventors: Harald Arno Butterweck, Theresa Friederike Bauer, Lucia Hofbauer, Wolfgang Teschner, Oliver Zoechling, Hans-Peter Schwarz, Christa Mayer, Meinhard Hasslacher
  • NUCLEOPHILIC CATALYSTS FOR OXIME LINKAGE
    Publication number: 20120035344
    Abstract: The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime or hydrazone linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer, and wherein the conjugation is carried out in the presence of a nucleophilic catalyst.
    Type: Application
    Filed: July 29, 2011
    Publication date: February 9, 2012
    Applicants: BAXTER HEALTHCARE S.A., BAXTER INTERNATIONAL INC.
    Inventors: Juergen Siekmann, Stefan Haider, Hanspeter Rottensteiner, Andreas Ivens, Peter Turecek, Oliver Zoechling
  • Method for production of a C1 esterase inhibitor (C1-INH)-containing composition
    Publication number: 20010019839
    Abstract: A method is described for production of a C1-INH esterase inhibitor (C1-INH)-containing composition, which includes the following steps:
    Type: Application
    Filed: December 21, 2000
    Publication date: September 6, 2001
    Inventors: Wolfgang Schoenhofer, Hans-Peter Schwarz, Oliver Zoechling, Yendra Linnau