Abstract: The safety device includes a tubular body configured to receive a barrel, a head arrangement configured to abut against the flange and to lock into a flange, at least two actuation arms connecting the tubular body and the head arrangement, said actuation arms having a proximal link connected to the head arrangement by a proximal hinge and a distal link connected to the tubular body by a distal hinge. The proximal link and the distal link are connected by an intermediate hinge. The actuation arm is movable between a collapsed position in which the tubular body is maintained in a position proximally close to the flange uncovering the needle and an extended position in which the tubular body is maintained in a position distally distant from the head arrangement shielding the needle; a locking means for maintaining the actuation arms in a collapsed position and a locking means for maintaining the actuation arms in an extended position.

Abstract: The safety device includes a tubular body extending along a longitudinal axis (A), the tubular body being configured to receive the barrel, an annular head configured to abut against the flange; one actuation arm connecting the tubular body and the annular head, the actuation arm being movable by a user between a collapsed position in which the tubular body is maintained by the actuation arm in a position proximally close to the flange uncovering the needle and an extended position in which the tubular body is maintained in a position distally distant from the flange shielding the needle; one finger resting arrangement connected to the annular head; a locking means for maintaining the actuation arm in a collapsed position and a locking means for maintaining the actuation arm in an extended position.

Abstract: The safety device includes a tubular body configured to receive a barrel, a head arrangement configured to abut against the flange and to lock into a flange, at least two actuation arms connecting the tubular body and the head arrangement, said actuation arms having a proximal link connected to the head arrangement by a proximal hinge and a distal link connected to the tubular body by a distal hinge, the proximal link and the distal link being connected by an intermediate hinge, the actuation arm being movable between a collapsed position in which the tubular body is maintained in a position proximally close to the flange uncovering the needle and an extended position in which the tubular body is maintained in a position distally distant from the head arrangement shielding the needle; a locking means for maintaining the actuation arms in a collapsed position and a biasing member for maintaining the actuation arms in an extended position.

Abstract: Provided herein is a drug delivery device including a syringe barrel having a proximal end, a distal end, and a sidewall arranged between the proximal end and the distal end defining an interior configured to hold a composition, a plunger rod received at least partially within the interior of the syringe, the plunger rod having a proximal end, a distal end, and a stopper arranged at the distal end, and a sensor assembly, including a capacitive element and a short-range communication device in electrical communication with the capacitive element, wherein the short-range communication device is capable of measuring capacitance at the capacitive element.

Abstract: A process for preparing in situ an aqueous gel ink with fixed color comprising the following steps: (i) preparing a gel-based matrix of aqueous ink comprising ester(s) of retinol represented by formula (I), and (ii) adding a solution of gold salts (Au3+) to the gel-based matrix of aqueous ink prepared in step (i), to obtain an aqueous gel ink with fixed color with gold nanoparticles dispersed therein. An aqueous gel ink with fixed color obtained according to the process of the invention, comprising the ester of retinol represented by formula (I) and gold nanoparticles. A writing instrument comprising an aqueous gel ink with fixed color.

Abstract: There is a process for preparing in situ an aqueous gel ink with variable color having the following steps: (i) preparing a gel-based matrix of aqueous ink comprising a reducing agent, (ii) adding a solution of metallic salts, (iii) adding iron powder to obtain an aqueous gel ink with variable color, wherein the steps (ii) and (iii) can be interchanged. There also is an aqueous gel ink with variable color obtained according to the process of the disclosure, having a reducing agent, metallic nanoparticles and iron powder. There further is a writing instrument having an aqueous gel ink with variable color according to the disclosure.

Abstract: A process for preparing in situ an aqueous gel ink with variable color comprising the following steps: (i) preparing a gel-based matrix of aqueous ink comprising an N-Acyl-aminophenol, wherein the hydroxyl group is preferably in meta or para position on the benzenic group, and (ii) adding a solution of silver salts to the gel-based matrix of aqueous ink prepared in step (i), to obtain an aqueous gel ink with variable color with silver nanoparticles disposed therein. An aqueous gel ink with variable color obtained according to process for preparing, comprising an N-Acyl-aminophenol, wherein the hydroxyl group is preferably in meta or para position on the benzenic group and silver nanoparticles. A writing instrument comprising an aqueous gel ink with variable color.

Abstract: The present invention concerns a process for preparing an aqueous gel ink with fixed color comprising the following steps: (i) preparing a gel-based matrix of aqueous ink; (ii) preparing an aqueous suspension of silver nanoparticles with a fixed color by mixing silver salts with: —water, —a mixture of at least an alkali metal or alkaline earth metal salt of citrate, —an oxidizing agent, preferably hydrogen peroxide H2O2, —and polyvinylpyrrolidone; (iii) adding under agitation the aqueous suspension of silver nanoparticles obtained in step (ii) to the gel-based matrix of aqueous ink obtained in step (i), to obtain an aqueous gel ink with fixed color with silver nanoparticles dispersed therein.

Abstract: The present invention concerns a process for preparing in situ an aqueous gel ink with variable color comprising the following steps: (i) preparing a gel-based matrix of aqueous ink comprising an N-Acyl-aminophenol, wherein said hydroxyl group is preferably in meta or in para position on the benzenic group, and (ii) adding a solution of silver salts to the gel-based matrix of aqueous ink prepared in step (i), to obtain an aqueous gel ink with variable color with silver nanoparticles dispersed therein. The present invention also relates to an aqueous gel ink with variable color obtained according to the process of the invention, comprising an N-Acyl-aminophenol, wherein said hydroxyl group is preferably in meta or in para position on the benzenic group and silver nanoparticles. The invention finally concerns a writing instrument comprising an aqueous gel ink with variable color according to the invention.

Abstract: The invention relates a process for preparing an aqueous gel ink with fixed color comprising the following steps: (i) preparing a gel-based matrix of aqueous ink; (ii) preparing an aqueous suspension of gold or silver nanoparticles with a fixed color; (iii) adding the aqueous suspension of gold or silver nanoparticles obtained in step (ii) to the gel-based matrix of aqueous ink obtained in step (i).

Abstract: The present invention concerns a process for preparing an aqueous gel ink with fixed color comprising the following steps: (i) preparing a gel-based matrix of aqueous ink; (ii) preparing an aqueous suspension of silver nanoparticles with fixed color by mixing silver salts with: water, a mixture of at least an alkali metal or alkaline earth metal salt of citrate, preferably an alkali citrate salt and an alkali metal hydride, preferably NaBH4, a further reducing agent, preferably ascorbic acid, and oxidizing agent, preferably hydrogen peroxide H2O2 (iii) adding under agitation the aqueous suspension of silver nanoparticles obtained in step (ii) to the gel-based matrix of aqueous ink obtained in step (i), to obtain an aqueous gel ink with fixed color with silver nanoparticles dispersed therein

Abstract: The present invention concerns a process for preparing in situ an aqueous gel ink with fixed color comprising the following steps: (i) preparing a gel-based matrix of aqueous ink comprising ester(s) of retinol represented by formula (I), and (ii) adding a solution of gold salts (Au3+) to the gel-based matrix of aqueous ink prepared in step (i), to obtain an aqueous gel ink with fixed color with gold nanoparticles dispersed therein. The present invention also relates to an aqueous gel ink with fixed color obtained according to the process of the invention, comprising said ester of retinol represented by formula (I) and gold nanoparticles. The invention finally concerns a writing instrument comprising an aqueous gel ink with fixed color according to the invention.

Abstract: The present invention concerns a process for preparing in situ an aqueous gel ink with fixed color comprising the following steps: (i) preparing a gel-based matrix of aqueous ink comprising reducing agent chosen in the group consisting of citric acid and/or derivatives of citric acid, (ii) adding a solution of gold salts, (iii) adding iron powder, (iv) adding polyvinylpyrrolidone to obtain an aqueous gel ink with fixed color, wherein the steps (ii) and (iii) can be interchanged. The present invention also relates to an aqueous gel ink with fixed color obtained according to the process of the invention, comprising citric acid and derivatives, gold nanoparticles, and iron powder. The invention finally concerns a writing instrument comprising an aqueous gel ink with fixed color according to the invention.

Abstract: The present invention concerns a process for preparing in situ an aqueous gel ink with variable color comprising the following steps: (i) preparing a gel-based matrix of aqueous ink comprising 0.005 to 0.1 mol·L?1 of ester(s) of retinol represented by formula (I), and (ii) adding a solution of 0.002 to 0.05 mol·L?1 silver salts (Ag+) to the gel-based matrix of aqueous ink prepared in step (i), to obtain an aqueous gel ink with variable color with silver nanoparticles dispersed therein. The present invention also relates to an aqueous gel ink with variable color obtained according to the process of the invention, comprising said ester of retinol represented by formula (I) and silver nanoparticles.

Abstract: There is a process for preparing in situ an aqueous gel ink with variable color having the following steps: (i) preparing a gel-based matrix of aqueous ink comprising a reducing agent, (ii) adding a solution of metallic salts, (iii) adding iron powder to obtain an aqueous gel ink with variable color, wherein the steps (ii) and (iii) can be interchanged. There also is an aqueous gel ink with variable color obtained according to the process of the disclosure, having a reducing agent, metallic nanoparticles and iron powder. There further is a writing instrument having an aqueous gel ink with variable color according to the disclosure.

Abstract: There is a process for preparing in situ an aqueous gel ink with fixed color having the following steps: (i) preparing a gel-based matrix of aqueous ink comprising 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid as reducing agent, and (ii) adding a solution of metallic salts to the gel-based matrix of aqueous ink prepared in step (i), to obtain an aqueous gel ink with fixed color with metallic nanoparticles dispersed therein. There is also an aqueous gel ink with fixed color obtained according to the process of the disclosure, comprising 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid and metallic nanoparticles. There is also a writing instrument comprising an aqueous gel ink with fixed color according to the disclosure.

Abstract: A writing instrument including a main body provided with a writing tip. The writing tip being supplied with ink by a free ink-type reservoir equipped with a pressure regulating device for regulating the pressure within the reservoir. The pressure regulating device includes at least one microfluidic valve.

Abstract: A compensation membrane and a pen or the equivalent including a compensation membrane. The compensation membrane being configured for compensating a pressure difference between the outside and the inside of a free ink reservoir of a pen or the equivalent. The membrane including a first portion having a first rigidity and a second portion having a second rigidity, the first rigidity being less than the second rigidity.

Abstract: A writing instrument including a main body provided with a writing tip. The writing tip being supplied with ink by a free ink-type reservoir equipped with a pressure regulating device for regulating the pressure within the reservoir. The pressure regulating device includes at least one microfluidic valve.

Abstract: A compensation membrane and a pen or the equivalent including a compensation membrane. The compensation membrane being configured for compensating a pressure difference between the outside and the inside of a free ink reservoir of a pen or the equivalent. The membrane including a first portion having a first rigidity and a second portion having a second rigidity, the first rigidity being less than the second rigidity.