Patents by Inventor Olivier Bezencon

Olivier Bezencon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CYCLOBUTYL-UREA DERIVATIVES
    Publication number: 20230303486
    Abstract: The invention relates to compounds of Formula (I) wherein X1, X2, X3, L, RX4, R1, R2A, R2B, R3, R4, R5, and R6 are as described in the description; to their preparation, to pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing one or more compounds of Formula (I), and to the use of such compounds as medicaments, especially as Kv7 openers.
    Type: Application
    Filed: June 24, 2021
    Publication date: September 28, 2023
    Inventors: Olivier BEZENCON, Caroline DEYMIER, Jens-Uwe PETERS, Romain SIEGRIST, Jean-Philippe SURIVET
  • SPIROUREA DERIVATIVES
    Publication number: 20230136562
    Abstract: The invention relates to compounds of Formula (I) wherein X1, X2, X3, Y, R1, R2A, R2B, R3, and R4 are as described in the description; to their preparation, to pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing one or more compounds of Formula (I), and to the use of such compounds as medicaments, especially as Kv7 openers.
    Type: Application
    Filed: April 27, 2021
    Publication date: May 4, 2023
    Inventors: Olivier BEZENCON, Caroline DEYMIER, Jens-Uwe PETERS, Romain SIEGRIST, Jean-Philippe SURIVET
  • Triazole compounds as T-type calcium channel blockers
    Patent number: 10246426
    Abstract: The invention relates to compounds of formula (I) wherein X, Y, R1, R2, (R4)n, and (R5)m are as defined in the description, and to pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium T-channel blockers.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: April 2, 2019
    Assignee: IDORSIA PHARMACEUTICALS LTD
    Inventors: Olivier Bezencon, John Gatfield, Bibia Heidmann, Romain Siegrist, Simon Stamm
  • Pyrazole compounds and their use as T-type calcium channel blockers
    Patent number: 10065929
    Abstract: The invention relates to compounds of formula (I) wherein X, Y, R1, R2, (R4)n, and (R5)m are as defined in the description, and to pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium T-channel blockers.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: September 4, 2018
    Assignee: IDORSIA PHARMACEUTICALS LTD
    Inventors: Romain Siegrist, Bibia Heidmann, Simon Stamm, John Gatfield, Olivier Bezencon
  • TRIAZOLE COMPOUNDS AS T-TYPE CALCIUM CHANNEL BLOCKERS
    Publication number: 20180230109
    Abstract: The invention relates to compounds of formula (I) wherein X, Y, R1, R2, (R4)n, and (R5)m are as defined in the description, and to pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium T-channel blockers.
    Type: Application
    Filed: September 14, 2015
    Publication date: August 16, 2018
    Applicant: ACTELION PHARMACEUTICALS LTD
    Inventors: Olivier BEZENCON, John GATFIELD, Bibia HEIDMANN, Romain SIEGRIST, Simon STAMM
  • PYRAZOLE COMPOUNDS AND THEIR USE AS T-TYPE CALCIUM CHANNEL BLOCKERS
    Publication number: 20180105496
    Abstract: The invention relates to compounds of formula (I) wherein X, Y, R1, R2, (R4)n, and (R5)m are as defined in the description, and to pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium T-channel blockers.
    Type: Application
    Filed: December 19, 2017
    Publication date: April 19, 2018
    Applicant: IDORSIA PHARMACEUTICALS LTD
    Inventors: Romain SIEGRIST, Bibia HEIDMANN, Simon STAMM, John GATFIELD, Olivier BEZENCON
  • Pyrazole compounds and their use as T-type calcium channel blockers
    Patent number: 9932314
    Abstract: The invention relates to compounds of formula (I) wherein X, Y, R1, R2, (R4)n, and (R5)m are as defined in the description, and to pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium T-channel blockers.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: April 3, 2018
    Assignee: IDORSIA PHARMACEUTICALS LTD
    Inventors: Romain Siegrist, Bibia Heidmann, Simon Stamm, John Gatfield, Olivier Bezencon
  • PYRAZOLE COMPOUNDS AND THEIR USE AS T-TYPE CALCIUM CHANNEL BLOCKERS
    Publication number: 20170096399
    Abstract: The invention relates to compounds of formula (I) wherein X, Y, R1, R2, (R4)n, and (R5)m are as defined in the description, and to pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium T-channel blockers.
    Type: Application
    Filed: June 2, 2015
    Publication date: April 6, 2017
    Inventors: Romain SIEGRIST, Bibia HEIDMANN, Simon STAMM, John GATFIELD, Olivier BEZENCON
  • Bicyclononene derivatives
    Patent number: 8138340
    Abstract: The invention relates to novel bicyclononene derivatives of Formula (I); and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
    Type: Grant
    Filed: August 22, 2005
    Date of Patent: March 20, 2012
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Olivier Bezencon, Christoph Boss, Daniel Bur, Olivier Corminboeuf, Walter Fiśchli, Corinna Grisostomi, Lubos Remen, Sylvia Richard-Bildstein, Thierry Sifferlen, Thomas Weller
  • Secondary amines as renin inhibitors
    Patent number: 7968720
    Abstract: The invention relates to novel secondary amine derivatives of formula (I) and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
    Type: Grant
    Filed: January 31, 2007
    Date of Patent: June 28, 2011
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Olivier Bezencon, Daniel Bur, Olivier Corminboeuf, Daniel Dube, Corinna Grisostomi, Dwight MacDonald, Dan McKay, David Powell, Lubos Remen, Sylvia Richard-Bildstein, John Scheigetz, Michel Therien, Thomas Weller
  • Diazabicyclononene derivatives and use thereof
    Patent number: 7915259
    Abstract: The invention relates to a novel 3,9-diazabicyclo[3.3.1]nonene derivative of formula (I), enantiomers thereof, and their use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing at least one compound of formula (I): or (I?): and especially their use as inhibitors of renin.
    Type: Grant
    Filed: January 26, 2006
    Date of Patent: March 29, 2011
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Olivier Bezencon, Daniel Bur, Walter Fischli, Lubos Remen, Sylvia Richard-Bildstein, Thierry Sifferlen, Thomas Weller
  • NOVEL PIPERIDINE CARBOXYLIC ACID AMINE DERIVATIVES
    Publication number: 20100324052
    Abstract: The invention relates to novel piperidine carboxylic acid amide derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of these novel compounds, pharmaceutical compositions comprising such compounds and especially the use of such compounds as inhibitors of renin.
    Type: Application
    Filed: August 12, 2010
    Publication date: December 23, 2010
    Inventors: Olivier Bezencon, Christoph Boss, Daniel Bur, Austin Chih-Yu Chen, Olivier Corminboeuf, Daniel Dube, Walter Fischli, Corinna Grisostomi, Lubos Remen, Sylvia Richard-Bildstein, Thierry Sifferlen, Michel Therien, Thomas Weller
  • Piperidine carboxylic acid amide derivatives
    Patent number: 7799805
    Abstract: The invention relates to novel piperidine carboxylic acid amide derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of these novel compounds, pharmaceutical compositions comprising such compounds and especially the use of such compounds as inhibitors of renin.
    Type: Grant
    Filed: May 23, 2006
    Date of Patent: September 21, 2010
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Olivier Bezencon, Christoph Boss, Daniel Bur, Austin Chih-Yu Chen, Olivier Corminboeuf, Daniel Dube, Walter Fischli, Corinna Grisostomi, Lubos Remen, Sylvia Richard-Bildstein, Thierry Sifferlen, Michel Therien, Thomas Weller
  • Bicyclononene derivaties
    Publication number: 20090306123
    Abstract: The invention relates to novel bicyclononene derivatives of Formula (I); and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
    Type: Application
    Filed: August 22, 2005
    Publication date: December 10, 2009
    Inventors: Olivier Bezencon, Christoph Boss, Daniel Bur, Olivier Corminboeuf, Walter Fischli, Corinna Grisostomi, Lubos Remen, Sylvia Richard-Bildstein, Thierry Sifferlen, Thomas Weller
  • Secondary Amines as Renin Inhibitors
    Publication number: 20090176823
    Abstract: The invention relates to novel secondary amine derivatives of formula (I) and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
    Type: Application
    Filed: January 31, 2007
    Publication date: July 9, 2009
    Inventors: Olivier Bezencon, Daniel Bur, Olivier Corminboeuf, Daniel Dube, Corinna Grisostomi, Dwight MacDonald, Dan McKay, David Powell, Lubos Remen, Sylvia Richard-Bildstein, John Scheigetz, Michel Therien, Thomas Weller
  • Primary Amines as Renin Inhibitors
    Publication number: 20090088457
    Abstract: The invention relates to novel primary amine derivatives and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
    Type: Application
    Filed: March 1, 2007
    Publication date: April 2, 2009
    Applicant: Actelion Pharmaceuticals, Ltd.
    Inventors: Olivier Bezencon, Daniel Bur, Olivier Corminboeuf, Corinna Grisostomi, Lubos Remen, Sylvia Richard-Bildstein, Thomas Weller
  • AMINES
    Publication number: 20090062342
    Abstract: The invention relates to novel amine derivatives and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
    Type: Application
    Filed: March 7, 2007
    Publication date: March 5, 2009
    Applicant: Actelion Pharmaceuticals Ltd.
    Inventors: Olivier Bezencon, Daniel Bur, Olivier Corminboeuf, Corinna Grisostomi, Lubos Remen, Sylvia Richard-Bildstein, Thomas Weller
  • 7-ARYL-3, 9-DIAZABICYCLO(3.3.1)NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES
    Publication number: 20080312242
    Abstract: The invention relates to novel 3,9-diazabicyclo[3.3.1]nonene derivatives of formula (I) and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors or renin.
    Type: Application
    Filed: July 7, 2008
    Publication date: December 18, 2008
    Applicant: ACTELION PHARMACEUTICALS, LTD.
    Inventors: OLIVIER BEZENCON, DANIEL BUR, WALTER FISCHLI, LUBOS REMEN, SYLVIA RICHARD-BILDSTEIN, HANS-PETER WEBER, THOMAS WELLER
  • Novel Tetrahydropyridine Derivatives
    Publication number: 20080234305
    Abstract: The invention relates to novel tetrahydropyridine derivatives and use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
    Type: Application
    Filed: October 5, 2004
    Publication date: September 25, 2008
    Inventors: Olivier Bezencon, Daniel Bur, Walter Fischli, Lubos Remen, Sylvia Richard-Bildstein, Thierry Sifferlen, Thomas Weller
  • 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseases
    Patent number: 7427613
    Abstract: The invention relates to novel 3,9-diazabicyclo[3.3.1]nonene derivatives of formula (I) and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors or renin.
    Type: Grant
    Filed: April 8, 2003
    Date of Patent: September 23, 2008
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Olivier Bezencon, Daniel Bur, Walter Fischli, Lubos Remen, Sylvia Richard-Bildstein, Hans-Peter Weber, Thomas Weller