Patents by Inventor Olivier DE HENAU

Olivier DE HENAU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINATION THERAPY WITH ANTI-IL-8 ANTIBODIES AND ANTI-PD-1 ANTIBODIES FOR TREATING CANCER
    Publication number: 20230279096
    Abstract: Provided herein are methods for the clinical treatment of tumors (e.g., advanced solid tumors) in patients having certain levels of serum IL-8 using an anti-IL-8 antibody in combination with an anti-PD-1 antibody.
    Type: Application
    Filed: December 29, 2022
    Publication date: September 7, 2023
    Inventors: Michael CARLETON, David FELTQUATE, Olivier DE HENAU, Timothy Patrick REILLY, Tian CHEN, Ye FENG, Shu-Pang Ben HUANG, Ming ZHOU, Ramachandran SURESH
  • METHODS AND FORMULATIONS FOR ADMINISTRATION OF THIOCARBAMATE DERIVIATIVES A2A INHIBITORS
    Publication number: 20230165863
    Abstract: The present invention relates to thiocarbamate derivatives of Formula (I) which are useful as A2A adenosine receptor (A2AR) inhibitors. Especially, the present invention relates to methods and formulations for treating and/or preventing cancers in a subject with a pharmaceutical composition comprising a thiocarbamate derivative as adenosine A2A receptor inhibitor. The pharmaceutical composition of the invention is particularly useful for oral dosing in the treatment of cancer.
    Type: Application
    Filed: April 16, 2021
    Publication date: June 1, 2023
    Inventors: Olivier De Henau, Veronique Bodo, Joanne Lager, Chiara Martinoli, Manfred Schneider
  • Combination therapy with anti-IL-8 antibodies and anti-PD-1 antibodies for treating cancer
    Patent number: 11572405
    Abstract: Provided herein are methods for the clinical treatment of tumors (e.g., advanced solid tumors) in patients having certain levels of serum IL-8 using an anti-IL-8 antibody in combination with an anti-PD-1 antibody.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: February 7, 2023
    Assignee: Bristol-Myers Squibb Company
    Inventors: Michael Carleton, David Feltquate, Olivier De Henau, Timothy Patrick Reilly, Tian Chen, Ye Feng, Shu-Pang Ben Huang, Ming Zhou, Ramachandran Suresh
  • THIOCARBAMATE DERIVATIVES AS A2A INHIBITORS, PHARMACEUTICAL COMPOSITION THEREOF AND COMBINATIONS WITH ANTICANCER AGENTS
    Publication number: 20210069196
    Abstract: The present invention relates to thiocarbamate derivatives of Formula (I) which are useful as A2A adenosine receptor (A2AR) inhibitors Especially, the present invention relates to a pharmaceutical composition comprising an A2A inhibitor of Formula (I) and a lipid carrier such as lauroyl macrogol-32 glycerides, D-?-tocopherol-polyethylene glycol-1000 succinate or a mixture thereof. The pharmaceutical composition of the invention is particularly useful for oral dosing in the treatment of cancers. The present invention also relates to a combination comprising an A2A receptor inhibitor of Formula (I) and an anticancer agent. The anticancer agent is for example an immunotherapeutic agent, such as a checkpoint inhibitor. The invention further relates to a pharmaceutical composition and a kit of parts comprising such combination. Additionally, the combination of the invention is particularly useful for the treatment and/or prevention of cancers.
    Type: Application
    Filed: September 9, 2020
    Publication date: March 11, 2021
    Inventors: Stefano Crosignani, Paul Dickinson, Marcel de Matas, Erica Joke Katelijne Heleen Houthuys, Reece Gerrad Marillier, Chiara Martinoli, Olivier De Henau, Gregory Driessens
  • COMBINATION THERAPY WITH ANTI-IL-8 ANTIBODIES AND ANTI-PD-1 ANTIBODIES FOR TREATING CANCER
    Publication number: 20210054063
    Abstract: Provided herein are methods for the clinical treatment of tumors (e.g., advanced solid tumors) in patients having certain levels of serum IL-8 using an anti-IL-8 antibody in combination with an anti-PD-1 antibody.
    Type: Application
    Filed: January 11, 2019
    Publication date: February 25, 2021
    Inventors: Michael CARLETON, David FELTQUATE, Olivier DE HENAU, Timothy Patrick REILLY, Tian CHEN, Ye FENG, Shu-Pang Ben HUANG, Ming ZHOU, Ramachandran SURESH