Abstract: A device for creating a patterned field on a diopter includes: an objective lens within whose image focal plane the surface of the diopter lies; a light injection element emitting a collimated light beam; and an optical assembly between the element and the objective lens by which the object plane of the objective lens is optically conjugate with the image plane of the element. The assembly is configured so a collimated light beam from the element is emitted towards the objective lens to be reflected towards the surface of the diopter with an angle of incidence?the critical angle of the diopter, an optical device for forming patterns is in the object plane of the element, so the pattern formed by the optical device for forming patterns in transmitted light on the light beam in the object plane of the element is on the surface of the diopter.

Abstract: The present invention relates to a bone system model comprising a mineralized matrix and osteoblasts, chararacterized in that the osteoblasts are deposited onto the matrix so as to form a layer at confluence and/or nodules, and the osteoclasts are deposited onto said layer and/or said nodules, and also to bone system models affected by various pathologies. The invention also covers the uses for carrying out screenings and tests for aggressiveness and for toxicity.