Abstract: The present invention relates to mesoporous organosilica nanoparticles, the method of preparation thereof, and uses of the same in treatment by means of photodynamic therapy or in imaging.

Abstract: The subject matter of the present invention is a compound characterized in that it has the general formula (I): in which P1, X, n, A, L and L1 are as defined in Claim 1. The present invention also relates to a process for preparing said compounds (I) and to the use thereof for targeting the cation-independent mannose 6-phosphate receptor (CI-M6PR). The subject matter of the invention is also a conjugate of formula (III): in which P1, X, n, A, L and L?1 are as defined in Claim 6, and the use thereof: —in a method for therapeutic treatment of the human or animal body, in particular chosen from enzyme replacement therapy, photodynamic therapy or cancer treatment, and/or—in a method of diagnosis, in particular of diseases or of ailments associated with an increase or with a decrease in CI-M6PR expression.

Abstract: The invention relates to a method for detecting defects of at least one metal wire of a set of metal wires, in particular in a cable, the method including: a step of emitting a high-frequency ultrasound signal around a so-called specific frequency in the metal wire; a step of reflecting said ultrasound signal in the metal wire; and a step of receiving the reflected ultrasound signal. The emitted ultrasound signal enables the energisation of at least one high-frequency wave capable of propagating in a longitudinal direction of the metal wire and having a phase velocity that is slightly higher than a compression volume wave velocity in the metal from which the metal wire is made.

Abstract: The present invention relates to mesoporous organoslica nanoparticles, the method of preparation thereof, and uses of the same in treatment by means of photodynamic therapy or in imaging.

Abstract: The subject matter of the present invention is a compound characterized in that it has the general formula (I): in which P1, X, n, A, L and L1 are as defined in Claim 1. The present invention also relates to a process for preparing said compounds (I) and to the use thereof for targeting the cation-independent mannose 6-phosphate receptor (CI-M6PR). The subject matter of the invention is also a conjugate of formula (III): in which P1, X, n, A, L and L?1 are as defined in Claim 6, and the use thereof: in a method for therapeutic treatment of the human or animal body, in particular chosen from enzyme replacement therapy, photodynamic therapy or cancer treatment, and/or in a method of diagnosis, in particular of diseases or of ailments associated with an increase or with a decrease in CI-M6PR expression.

Abstract: The invention relates to a method for detecting defects of at least one metal wire of a set of metal wires, in particular in a cable, the method including: a step of emitting a high-frequency ultrasound signal around a so-called specific frequency in the metal wire; a step of reflecting said ultrasound signal in the metal wire; and a step of receiving the reflected ultrasound signal. The emitted ultrasound signal enables the energisation of at least one high-frequency wave capable of propagating in a longitudinal direction of the metal wire and having a phase velocity that is slightly higher than a compression volume wave velocity in the metal from which the metal wire is made.

Abstract: Disclosed are nanovectors of formula (I) that can be used simultaneously for the targeting, imaging and treatment, by photodynamic therapy, of cancer cells, and to biodegradable silicon nanoparticles containing a variety of photosensitizing molecules, in particular porphyrins, capable of targeting diseased cells and inducing cell death by excitation in the near-infrared region (>600 nm) in monophotonic and biphotonic modes. In formula (I), (AA) is a porous silicon nanoparticle.

Abstract: The present invention is related to a supportive sleepy heads neck pillow comprising a pillow with a bone structure support inside the pillow and a clip/strap system that is fixed to the bone structure, wherein the bone structure support is fully incased in the pillow, and the bone structure support comprises three parts, which may be adjustable; a neck bone support, an arm bone, and an upper back bone. The invention can also be used awake for comfort and support while relaxing, watching TV, playing video games, gambling, etc. It can also be used for head and neck support for people who have neck injuries, or to prevent neck injuries during transportation.

Abstract: The invention relates to a method for forming a deposit of a fragile material on a substrate (3) by spraying a powder (1) of said material, said method including the following steps: producing an aerosol containing said powder (1) in a so-called aerosol chamber (10); accelerating the aerosol through a nozzle (31) in a so-called deposition chamber (30) having a negative pressure relative to the aerosol chamber (10); and spraying the aerosol onto the substrate (3), wherein the grains constituting the powder (1) fragment and form said deposit upon impact with the substrate (3), said method being characterized in that the formation of the deposit is controlled on the basis of a three-dimensional digital model of said deposit. The invention also relates to a device for implementing said method.

Abstract: The embodiments disclosed herein are related to a supportive head and neck pillow with a supportive bone structure inside the pillow. The pillow is used for head and neck support, and comfort while sleeping sitting up during transportation. It can also be used for head and neck support for people who have neck injuries, or to prevent neck injuries during transportation. The sleepy heads neck pillow disclosed comprises a pillow with a bone structure support inside it.

Abstract: The embodiments disclosed herein are related to a supportive head and neck pillow with a supportive bone structure inside the pillow. The pillow is used for head and neck support, and comfort while sleeping sitting up during transportation. It can also be used for head and neck support for people who have neck injuries, or to prevent neck injuries during transportation. The sleepy heads neck pillow disclosed comprises a pillow with a bone structure support inside it.

Abstract: The embodiments disclosed herein are related to a supportive head and neck pillow with a supportive bone structure inside the pillow. The pillow is used for head and neck support, and comfort while sleeping sitting up during transportation. It can also be used for head and neck support for people who have neck injuries, or to prevent neck injuries during transportation. The sleepy heads neck pillow disclosed comprises a pillow with a bone structure support inside it.

Abstract: Disclosed are nanovectors of formula (I) that can be used simultaneously for the targeting, imaging and treatment, by photodynamic therapy, of cancer cells, and to biodegradable silicon nanoparticles containing a variety of photosensitizing molecules, in particular porphyrins, capable of targeting diseased cells and inducing cell death by excitation in the near-infrared region (>600 nm) in monophotonic and biphotonic modes. In formula (I), (AA) is a porous silicon nanoparticle.

Abstract: The invention relates to a method for forming a deposit of a fragile material on a substrate (3) by spraying a powder (1) of said material, said method including the following steps: producing an aerosol containing said powder (1) in a so-called aerosol chamber (10); accelerating the aerosol through a nozzle (31) in a so-called deposition chamber (30) having a negative pressure relative to the aerosol chamber (10); and spraying the aerosol onto the substrate (3), wherein the grains constituting the powder (1) fragment and form said deposit upon impact with the substrate (3), said method being characterized in that the formation of the deposit is controlled on the basis of a three-dimensional digital model of said deposit. The invention also relates to a device for implementing said method.

Abstract: The invention relates to compounds of formula (I) wherein the groups A and B represent independently from each other —CH?CH—, or —C?C—, the terms t, u, v, w represent, independently from each other, values ranging from 0 to 9, the groups Y1 and Y2 can represent independently from each other an alkyl group (linear, branched or substituted) carrying from 1 to 9 carbon atoms, the groups Z1, Z2, Z3, and Z4 can represent independently from each other a chemically reactive group W, such as OH, NH2, SH, the groups Z5 and Z6 represent independently from each other a hydrogen atom, silica nanoparticles functionalized by these compounds, and their use as drugs.

Abstract: Nanovectors are disclosed that make it possible to simultaneously target, image, and treat cancerous cells using photodynamic therapy. Also disclosed are novel molecules (I) derived from porphyrins, silica-based nanoparticles comprising the same, and their use in photodynamic therapy.

Abstract: The invention relates to compounds of formula (I) wherein the groups A and B represent independently from each other —CH?CH—, or —C?C—, the terms t, u, v, w represent, independently from each other, values ranging from 0 to 9, the groups Y1 and Y2 can represent independently from each other an alkyl group (linear, branched or substituted) carrying from 1 to 9 carbon atoms, the groups Z1, Z2, Z3, and Z4 can represent independently from each other a chemically reactive group W, such as OH, NH2, SH, the groups Z5 and Z6 represent independently from each other a hydrogen atom, silica nanoparticles functionalized by these compounds, and their use as drugs.

Abstract: The present invention is related to a supportive sleepy heads neck pillow comprising a pillow with a bone structure support inside the pillow and a clip/strap system that is fixed to the bone structure, wherein the bone structure support is fully incased in the pillow, and the bone structure support comprises three parts, which may be adjustable; a neck bone support, an arm bone, and an upper back bone. The invention can also be used awake for comfort and support while relaxing, watching TV, playing video games, gambling, etc. It can also be used for head and neck support for people who have neck injuries, or to prevent neck injuries during transportation.