Patents by Inventor Olivier Geneste

Olivier Geneste has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MCL-1 INHIBITOR ANTIBODY-DRUG CONJUGATES AND METHODS OF USE
    Publication number: 20230092679
    Abstract: Antibody-drug conjugates that bind to human oncology targets are disclosed. The antibody-drug conjugates comprise an Mcl-1 inhibitor drug moiety. The disclosure further relates to methods and compositions for use in the treatment of cancers by administering the antibody-drug conjugates provided herein. Linker-drug conjugates comprising an Mcl-1 inhibitor drug moiety and methods of making same are also disclosed.
    Type: Application
    Filed: May 19, 2020
    Publication date: March 23, 2023
    Inventors: Matthew T. Burger, Maia Chanrion, Frédéric Colland, Marton Csekei, Lea Delacour, Patrice Desos, Olivier Geneste, Jean-Michel Henlin, Vesela Kostova, Andras Kotschy, Ana Leticia Maragno, Eric McNeill, Mark G. Palermo, Francesca Rocchetti, Jérôme Starck, Bing Yu, Qiang Zhang, Ágnes Proszenyák, Szabolcs Sipos, Zhuoliang Chen, Katsumasa Nakajima, Joseph Anthony D'Alessio
  • MCL-1 INHIBITOR ANTIBODY-DRUG CONJUGATES AND METHODS OF USE
    Publication number: 20230081720
    Abstract: Anti-CD74 antibody-drug conjugates are disclosed. The anti-CD74 antibody-drug conjugates comprise an Mcl-1 inhibitor drug moiety and an anti-CD74 antibody or antigen-binding fragment thereof that binds an antigen target, e.g., an antigen expressed on a tumor or other cancer cell. The disclosure further relates to methods and compositions for use in the treatment of cancers by administering the antibody-drug conjugates provided herein. Linker-drug conjugates comprising an Mcl-1 inhibitor drug moiety and methods of making same are also disclosed.
    Type: Application
    Filed: May 19, 2020
    Publication date: March 16, 2023
    Inventors: Matthew T. Burger, Maia Chanrion, Frédéric Colland, Marton Csekei, Lea Delacour, Patrice Desos, Olivier Geneste, Jean-Michel Henlin, Vesela Kostova, Andras Kotschy, Ana Leticia Maragno, Eric McNeill, Mark G. Palermo, Francesca Rocchetti, Jérôme Starck, Bing Yu, Qiang Zhang, Ágnes Proszenyák, Szabolcs Sipos, Zhuoliang Chen, Katsumasa Nakajima, Joseph Anthony D'Alessio, John William Blankenship
  • Combination of a Mcl-1 inhibitor and a standard of care treatment for hematologic cancers, uses and pharmaceutical compositions thereof
    Patent number: 11466023
    Abstract: A combination comprising a Mcl-1 inhibitor and a second anticancer agent, wherein the second anticancer agent is selected from anthracyclines, cytarabine and hypomethylating agents, and compositions and uses thereof.
    Type: Grant
    Filed: June 21, 2018
    Date of Patent: October 11, 2022
    Assignees: LES LABORATOIRES SERVIER, NOVARTIS AG
    Inventors: Andrew Wei, Donia Moujalled, Giovanna Pomilio, Olivier Geneste, Ana Leticia Maragno
  • Substituted piperidines as inhibitors of ubiquitin specific protease 7
    Patent number: 11332472
    Abstract: Compounds of formula (I): wherein R1, R2, R3, B, W, Z, m and n are as defined in the description.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: May 17, 2022
    Assignees: LES LABORATOIRES SERVIER, VERNALIS (R&D) LTD
    Inventors: András Kotschy, Csaba Wéber, Attila Vasas, Árpád Kiss, Balázs Molnár, Ágnes Strofek, Vilibald Kun, James Brooke Murray, Alba Macias, Elodie Lewkowicz, Maïa Chanrion, Lisa Ivanschitz, Olivier Geneste
  • NEW AMINO-PYRIMIDONYL-PIPERIDINYL DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20210355106
    Abstract: wherein R1, R2, R3, R4, R5, n and Q are as defined in the description.
    Type: Application
    Filed: October 18, 2019
    Publication date: November 18, 2021
    Inventors: Csaba WÉBER, András KOTSCHY, Attila VASAS, Árpád KISS, Balázs MOLNÁR, Andrea FIUMANA, Alba MACIAS, James Brooke MURRAY, Didier DEMARLES, Lisa IVANSCHITZ, Olivier GENESTE, Kristóf HEGEDÜS, Péter SPRÁNITZ, Tibor SOÓS
  • PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20210290631
    Abstract: wherein A1, A2, R3, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
    Type: Application
    Filed: June 8, 2021
    Publication date: September 23, 2021
    Inventors: Arnaud LE TIRAN, Thierry LE DIGUARHER, Jérôme-Benoît STARCK, Jean-Michel HENLIN, Anne-Françoise GUILLOUZIC, Guillaume DE NANTEUIL, Olivier GENESTE, Imre FEJES, János TATAI, Miklós NYERGES, James Edward Paul DAVIDSON, James Brooke MURRAY, I-Jen CHEN, Didier DURAND
  • AMINO-PYRIMIDONYL DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20210221785
    Abstract: Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, J and n are as defined in the description.
    Type: Application
    Filed: July 4, 2019
    Publication date: July 22, 2021
    Inventors: Csaba WÉBER, András KOTSCHY, Attila VASAS, Árpád KISS, Balázs MOLNÁR, Alba MACIAS, Andrea FIUMANA, Nicolas DAVIES, James Brooke MURRAY, Emilie SELLIER, Didier DEMARLES, Lisa IVANSCHITZ, Olivier GENESTE
  • Pyrrole compounds, a process for their preparation and pharmaceutical
    Patent number: 11058689
    Abstract: Compounds of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
    Type: Grant
    Filed: May 4, 2020
    Date of Patent: July 13, 2021
    Assignees: LES LABORATOIRES SERVIER, VERNALIS (R&D) LTD
    Inventors: Arnaud Le Tiran, Thierry Le Diguarher, Jérôme-Benoît Starck, Jean-Michel Henlin, Anne-Françoise Guillouzic, Guillaume De Nanteuil, Olivier Geneste, Imre Fejes, János Tatai, Miklós Nyerges, James Edward Paul Davidson, James Brooke Murray, I-Jen Chen, Didier Durand
  • Substituted piperidines for the treatment of cancer
    Patent number: 11046681
    Abstract: Compounds of formula (I): wherein R1, R2, R3, n and W are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring pro-apoptotic and/or anti-proliferative agents.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: June 29, 2021
    Assignees: LES LABORATOIRES SERVIER, VERNALIS (R&D) LTD
    Inventors: András Kotschy, Csaba Wéber, Attila Vasas, Balázs Molnár, Árpád Kiss, Alba Macias, James Brooke Murray, Elodie Lewkowicz, Olivier Geneste, Maïa Chanrion, Didier Demarles
  • Isoindoline or isoquinoline compounds, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 11028070
    Abstract: Compound of formula (I): wherein Het, R3, R4, R5, R7, R8, R9, t, p, p?, q, and q? are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring pro-apoptotic agent.
    Type: Grant
    Filed: May 4, 2020
    Date of Patent: June 8, 2021
    Assignees: LES LABORATOIRES SERVIER, VERNALIS (R&D) LTD
    Inventors: James Edward Paul Davidson, James Brooke Murray, I-Jen Chen, Claire Walmsley, Mark Dodsworth, Johannes W. G. Meissner, Paul Brough, Imre Fejes, János Tatai, Miklós Nyerges, András Kotschy, Zoltán Szlávik, Olivier Geneste, Arnaud Le Tiran, Thierry Le Diguarher, Jean-Michel Henlin, Jérôme-Benoît Starck, Anne-Françoise Guillouzic, Guillaume De Nanteuil
  • NEW PIPERIDINYL DERIVATIVES AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7
    Publication number: 20200407363
    Abstract: Compounds of formula (I): wherein R1, R2, R3, B, W, Z, m and n are as defined in the description.
    Type: Application
    Filed: November 28, 2018
    Publication date: December 31, 2020
    Inventors: András KOTSCHY, Csaba WÉBER, Attila VASAS, Árpád KISS, Balázs MOLNÁR, Ágnes STROFEK, Vilibald KUN, James Brooke MURRAY, Alba MACIAS, Elodie LEWKOWICZ, Maïa CHANRION, Lisa IVANSCHITZ, Olivier GENESTE
  • COMBINATION OF A MCL-1 INHIBITOR AND A STANDARD OF CARE TREATMENT FOR HEMATOLOGIC CANCERS, USES AND PHARMACEUTICAL COMPOSITIONS THEREOF
    Publication number: 20200392151
    Abstract: A combination comprising a Mcl-1 inhibitor and a second anticancer agent, wherein the second anticancer agent is selected from anthracyclines, cytarabine and hypomethylating agents, and compositions and uses thereof.
    Type: Application
    Filed: June 21, 2018
    Publication date: December 17, 2020
    Inventors: Andrew WEI, Donia MOUJALLED, Giovanna POMILIO, Olivier GENESTE, Ana Leticia MARAGNO
  • Combination of a MCL-1 inhibitor and a taxane compound, uses and pharmaceutical compositions thereof
    Patent number: 10765680
    Abstract: A combination comprising a MCL-1 inhibitor and a taxane compound, and compositions and uses thereof.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: September 8, 2020
    Assignees: LES LABORATORIES SERVIER, NOVARTIS AG
    Inventors: Dale Porter, Ensar Halilovic, Maïa Chanrion, Ana Leticia Maragno, Olivier Geneste, Delphine Merino, James Whittle, François Vaillant, Jane Visvader, Geoffrey Lindeman, Guillaume Lessene, Elisabetta Marangoni
  • PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20200261464
    Abstract: Compounds of formula (1): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
    Type: Application
    Filed: May 4, 2020
    Publication date: August 20, 2020
    Inventors: Arnaud LE TIRAN, Thierry LE DIGUARHER, Jérôme-Benoît STARCK, Jean-Michel HENLIN, Anne-Françoise GUILLOUZIC, Guillaume DE NANTEUIL, Olivier GENESTE, lmre FEJES, János TATAI, Miklós NYERGES, James Edward Paul DAVIDSON, James Brooke MURRAY, I-Jen CHEN, Didier DURAND
  • ISOINDOLINE OR ISOQUINOLINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20200262816
    Abstract: Compound of formula (I): wherein Het, R3, R4, R5, R7, R8, R9, t, p, p?, q, and q? are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring pro-apoptotic agent.
    Type: Application
    Filed: May 4, 2020
    Publication date: August 20, 2020
    Inventors: James Edward Paul DAVIDSON, James Brooke MURRAY, I-Jen CHEN, Claire WALMSLEY, Mark DODSWORTH, Johannes W.G. MEISSNER, Paul BROUGH, lmre FEJES, János TATAI, Miklós NYERGES, András KOTSCHY, Zoltán SZLÁVIK, Olivier GENESTE, Arnaud LE TIRAN, Thierry LE DIGUARHER, Jean-Michel HENLIN, Jérôme-Benoît STARCK, Anne-Françoise GUILLOUZIC, Guillaume DE NANTEUIL
  • Hydroxyester derivatives, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 10711010
    Abstract: Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R13, Ra, Rb, A and n are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.
    Type: Grant
    Filed: January 15, 2019
    Date of Patent: July 14, 2020
    Assignees: LES LABORATORIES SERVIER, VERNALIS (R&d) LTD
    Inventors: Zoltán Szlávik, András Kotschy, Maïa Chanrion, Didier Demarles, Olivier Geneste, James Edward Paul Davidson, James Brooke Murray, Szabolcs Sipos, Attila Paczal, Balázs Bálint
  • Pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 10688101
    Abstract: Compounds of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: June 23, 2020
    Assignees: LES LABORATORIES SERVIER, VERNALIS (R&D) LTD
    Inventors: Arnaud Le Tiran, Thierry Le Diguarher, Jérôme-Benoît Starck, Jean-Michel Henlin, Anne-Françoise Guillouzic, Guillaume De Nanteuil, Olivier Geneste, Imre Fejes, János Tatai, Miklós Nyerges, James Edward Paul Davidson, James Brooke Murray, I-Jen Chen, Didier Durand
  • Isoindoline or isoquinoline compounds, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 10689364
    Abstract: Compounds of formula (I): wherein Het, R3, R4, R5, R7, R8, R9, T, p, p?, q, and q? are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: June 23, 2020
    Assignees: LES LABORATOIRES SERVIER, VERNALIS (R&D) LTD
    Inventors: James Edward Paul Davidson, James Brooke Murray, I-Jen Chen, Claire Walmsley, Mark Dodsworth, Johannes W. G. Meissner, Paul Brough, Imre Fejes, János Tatai, Miklós Nyerges, András Kotschy, Zoltán Szlávik, Olivier Geneste, Arnaud Le Tiran, Thierry Le Diguarher, Jean-Michel Henlin, Jérôme-Benoît Starck, Anne-Françoise Guillouzic, Guillaume De Nanteuil
  • Indole and pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 10662173
    Abstract: Compounds of formula (I): wherein Ra, Rb, Rc, Rd, R3, R4, R5, A1, A2, T and W are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: May 26, 2020
    Assignees: LES LABORATOIRES SERVIER, VERNALIS (R&D) LTD
    Inventors: Patrick Casara, Thierry Le Diguarher, Jean-Michel Henlin, Jérôme-Benoît Starck, Arnaud Le Tiran, Guillaume De Nanteuil, Olivier Geneste, James Edward Paul Davidson, James Brooke Murray, I-Jen Chen, Claire Walmsley, Christopher John Graham, Stuart Ray, Daniel Maddox, Simon Bedford
  • (Hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 10654849
    Abstract: Compounds of formula (I): wherein R1, R2, J, K, L, n and W are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring pro-apoptotic and/or anti-proliferative agents.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: May 19, 2020
    Assignees: LES LABORATOIRES SERVIER, VERNALIS (R&D) LTD
    Inventors: András Kotschy, Csaba Wéber, Attila Vasas, Balázs Molnár, árpád Kiss, Alba Macias, James Brooke Murray, Elodie Lewkowicz, Olivier Geneste, Mäia Chanrion, Didier Demarles, Lisa Ivanschitz