Abstract: Methods and systems for constructing gene modules with regulator genes and target genes are provided. A Gaussian mixed model can construct gene modules using RNA sequencing data. Sets of gene modules can be compared to identify shared or unique biological processes.

Abstract: Systems and methods for synthetic image generation include a method of generating synthetic histological slide images that includes translating each of several RNA-Seq records into a latent space, training a first diffusion model to produce a first synthetic histological slide image at a lower resolution using the translated RNA-Seq records and associated histological slides, training a second diffusion model to upscale lower resolution synthetic histological slide images produced by the first diffusion model to higher resolution synthetic histological slide images, obtaining a given RNA-Seq record, translating the given RNA-Seq record into the latent space, providing the latent representation of the given RNA-Seq record to the trained first diffusion model to generate a given lower resolution synthetic histological slide image, and providing the given lower resolution synthetic histological slide image to the trained second diffusion model to generate a given higher resolution synthetic histological slide im

Abstract: Present invention concerns a kit and an in vitro method, for evaluating a biological stage of an HCC tumour in an individual, based on a sample from the individual, comprising: deriving from the sample a profile data set, the profile data set on a the gene expression panel with the markers CCNG2, EGLN3, ERO1L, FGF21, MAT1A, RCL1 and WDR45L or a substantially similar marker, being a quantitative measure of the amount of a distinct RNA or protein constituent in the panel so that measurement of the constituents enables evaluation of the biological condition or the biological behaviour HCC tumours.