Patents by Inventor Olivier KOSMIDER

Olivier KOSMIDER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220119516
    Abstract: The invention relates to the domain of anemia, iron overload and myeloid malignancy. The inventors identify a variant transcript of ERFE specific of SF3B1MUT MDS that contributes to increased concentration of ERFE protein leading to hepcidin suppression and iron accumulation in patients. This transcript contains an in-frame added intronic sequence of 12 nucleotides not inducing a stop codon that may be translated into a variant protein with an additional 4 amino acids. By using deep mass spectrometry, they identified a peptide corresponding to the added polypeptide VPQF (SEQ ID NO: 5) demonstrating the active production of a variant protein by bone marrow erythroblasts of patients with a SF3B1-mutated MDS. This variant can be used as a pertinent biomarker of clonal erythropoiesis for monitoring treatments of anemia in SF3B1MUT patients.
    Type: Application
    Filed: January 15, 2020
    Publication date: April 21, 2022
    Inventors: Michaela FONTENAY, Olivier KOSMIDER, François GUILLONNEAU, Léon KAUTZ, Samar ALSAFADI, Carine LEFEVRE, Marc-Henri STERN, Alexandre HOUY