Abstract: A regionally time multiplexed emulation system includes an emulator for emulating a circuit design. The emulator includes a plurality of reconfigurable logic devices with buffered I/O pins and reconfigurable logic elements. The reconfigurable logic devices are reconfigurable to emulate a circuit design using at least one user clock to clock the logic elements and at least one signal routing clock to time multiplex the routing of emulation signals between the reconfigurable logic devices, with the at least one signal routing clock being independent of the at least one user clock.