Abstract: The current invention concerns a method for determining the presence of a (pre)cancerous cell in a liquid cell sample, comprising the steps of: —suspending and preserving a cell sample obtained from a subject in a sample vial comprising a liquid medium, said liquid medium comprises means for labeling cells or epitope(s) on or in said cells; —obtaining data from said labelled liquid cell sample; and —determining the presence of said (pre)cancerous cells based on said obtained data; characterized in that said data comprises morphological data and biomarker data. In a further aspect, the invention relates to a liquid medium for fixing, preserving and labeling cells in a cell sample and a sample vial specifically designed to be used in conjunction with the current method.

Abstract: The current invention concerns a method for detecting cancerous cells and/or classifying cells in a cell sample comprising the following steps: providing a cell sample; obtaining holographic information from said cell sample by digital holographic microscopy (DHM); deriving at least one cellular parameter from said holographic information, and; classifying said cells of cells sample; characterized in that said classification occurs by appointing a Scoring Factor to said cells of cell sample, based on said cellular parameters. In a second aspect, a system for the detection of cancerous cells and/or classification of cells in a cell sample is provided, employing the method as disclosed in the invention. In a final aspect, a method for updating and/or improving a database comprising thresholds linked to holographic information and the database related thereof is equally disclosed.

Abstract: The current invention concerns a sample vial for receiving a liquid cell sample, to be used in conjunction with a digital holographic microscope (DHM), said sample vial comprises at least two compartments in fluid connection with one another, said compartments comprising at least one pair of screening surfaces, said screening surfaces are essentially flat; and characterized in that the distance between the pair of screening surfaces of the second compartment is smaller than the distance between the pair of screening surfaces of the first compartment. In a second and third aspect, the current invention pertains to a method and system for analyzing a liquid cell sample by DHM, employing the sample vial of the current invention.

Abstract: The current invention concerns a method for detecting cancerous cells and/or classifying cells in a cell sample comprising the following steps: providing a cell sample; obtaining holographic information from said cell sample by digital holographic microscopy (DHM); deriving at least one cellular parameter from said holographic information, and; classifying said cells of cells sample; characterized in that said classification occurs by appointing a Scoring Factor to said cells of cell sample, based on said cellular parameters. In a second aspect, a system for the detection of cancerous cells and/or classification of cells in a cell sample is provided, employing the method as disclosed in the invention. In a final aspect, a method for updating and/or improving a database comprising thresholds linked to holographic information and the database related thereof is equally disclosed.

Abstract: The current invention concerns a method for detecting cancerous cells and/or classifying cells in a cell sample comprising the following steps: providing a cell sample; obtaining holographic information from said cell sample by digital holographic microscopy (DHM); deriving at least one cellular parameter from said holographic information, and; classifying said cells of cells sample; characterized in that said classification occurs by appointing a Scoring Factor to said cells of cell sample, based on said cellular parameters. In a second aspect, a system for the detection of cancerous cells and/or classification of cells in a cell sample is provided, employing the method as disclosed in the invention. In a final aspect, a method for updating and/or improving a database comprising thresholds linked to holographic information and the database related thereof is equally disclosed.

Abstract: The current invention concerns a sample vial for receiving a liquid cell sample, to be used in conjunction with a digital holographic microscope (DHM), said sample vial comprises at least two compartments in fluid connection with one another, said compartments comprising at least one pair of screening surfaces, said screening surfaces are essentially flat; and characterized in that the distance between the pair of screening surfaces of the second compartment is smaller than the distance between the pair of screening surfaces of the first compartment. In a second and third aspect, the current invention pertains to a method and system for analyzing a liquid cell sample by DHM, employing the sample vial of the current invention.

Abstract: The current invention concerns a method for determining the presence of a (pre)cancerous cell in a liquid cell sample, comprising the steps of: —suspending and preserving a cell sample obtained from a subject in a sample vial comprising a liquid medium, said liquid medium comprises means for labeling cells or epitope(s) on or in said cells; —obtaining data from said labelled liquid cell sample; and —determining the presence of said (pre)cancerous cells based on said obtained data; characterized in that said data comprises morphological data and biomarker data. In a further aspect, the invention relates to a liquid medium for fixing, preserving and labeling cells in a cell sample and a sample vial specifically designed to be used in conjunction with the current method.

Abstract: The current invention concerns an object database comprising a set of object entries, which comprise object properties, whereby said object properties comprise obtained object properties, which comprise DHM-obtained object properties and preferably object identification properties, characterized in that said DHM-obtained object properties comprise properties about a sample comprising said objects, said information derived from information acquired by a digital holographic microscope (DHM) and whereby preferably said object identification properties comprise information about the objects which allow identification of the object between the object database and an database. The invention furthermore discloses an object database updating method and a computing system comprising an object database and object database updating method as disclosed in the current invention.

Abstract: The current invention concerns a method for detecting cancerous cells and/or classifying cells in a cell sample comprising the following steps: providing a cell sample; obtaining holographic information from said cell sample by digital holographic microscopy (DHM); deriving at least one cellular parameter from said holographic information, and; classifying said cells of cells sample; characterized in that said classification occurs by appointing a Scoring Factor to said cells of cell sample, based on said cellular parameters. In a second aspect, a system for the detection of cancerous cells and/or classification of cells in a cell sample is provided, employing the method as disclosed in the invention. In a final aspect, a method for updating and/or improving a database comprising thresholds linked to holographic information and the database related thereof is equally disclosed.