Patent number: 6716843
Abstract: Compound of formula (I):
wherein:
represents an optionally substituted, 5-membered, nitrogen-containing heterocycle,
R1 represents hydrogen, alkyl, acyl, prolyl, alanyl, histidylprolyl or phenylalanylprolyl,
Ak represents an alkylene or heteroalkylene chain,
X represents a single bond or optionally substituted phenylene,
R2 represents optionally substituted alkyl, (C3-C10)cycloalkyl, or —NR2aR2b wherein R2a and R2b, which may be the same or different, each represent hydrogen or alkyl or, together with the nitrogen atom carrying them, form a nitrogen-containing heterocycle,
Y represents
R3 represents hydrogen or a group selected from alkyl, (C3-C7) cycloalkyl and aryl,
R4, R5 and R6, which may be the same or different, each represent hydrogen or alkyl, or R4 and R6, or R5 and R6, together with the atoms carrying them, form an imidazolidine or dihydrobenzimidazole ring,
its optical isomers and addition salts thereof with a pharmaceutically
Type:
Grant
Filed:
March 28, 2002
Date of Patent:
April 6, 2004
Assignee:
Les Laboratoires Servier
Inventors:
Guillaume De Nanteuil, Bernard Portevin, Alain Benoist, Nigel Levens, Olivier Nosjean, Bernadette Husson-Robert