Abstract: A line of joint implant systems includes an implant including a cup to be affixed in one of the elements of the considered joint, defining a smooth inner cavity of substantially hemispherical shape. The implant also includes an insert, mobile within the inner cavity of the fixation cup and having its smooth outer surface intended to cooperate by ball-and-socket joint with the inner cavity, and defining in turn a smooth inner cavity of substantially hemispherical shape. The implant further includes a head or ball, solid with a second element of the joint, of spherical shape, intended to be received in the inner cavity of the mobile insert and to form a second ball-and-socket joint. The ratio of the inner diameter of the inner cavity of the fixation cup to the inner diameter of the inner cavity of the mobile insert is constant, whatever the diameter of the selected ball.

Abstract: The invention concerns new peptidomimetic (or peptoid) molecules for the prevention and/or treatment of chronic pain, particularly that resulting from peripheral neuropathies.

Abstract: A method of analyzing an image of a volume of tissue to determine a risk of developing breast cancer using a volume averaged sound speed within the volume. A method of determining a response to a treatment plan by determining a volume and a volume averaged sound speed of a region of interest within a volume of breast tissue and generating a combined metric from the volume and the volume averaged sound speed over the plurality of instances of time. A method of analyzing an image of a volume of tissue of a breast by applying a spatial filter to at least one ultrasound tomography image at the computing system and generating a stiffness map from the at least one ultrasound tomography image.

Abstract: Described herein are systems, and methods for aiding a user to classify a volume of tissue. A system as described herein may comprise: a plurality of parameters associated with image characteristics related to one or more images of a volume of tissue; a plurality of probabilities each associated with a potential classification of a region of the volume of tissue and each related to one or more parameters of the plurality of parameters, wherein the plurality of probabilities are assumed to be independent of one another; and a graphical display visible to a user, the display comprising a graphical representation of a subset of relevant parameters of the plurality of parameters, wherein the graphical representation informs a classification of the region of the volume of tissue, and wherein a probability of the classification is represented visually.

Abstract: A method and system for analyzing stiffness in a volume of tissue, the method including: emitting acoustic waveforms toward the volume of tissue with an array of ultrasound transmitters; detecting, with an array of ultrasound receivers, a set of acoustic signals derived from acoustic waveforms transmitted through the volume of tissue; generating, from the set of acoustic signals, a sound speed map and an acoustic attenuation map of a region of the volume of tissue, generating a stiffness map derived from combination of a set of sound speed parameter values of the sound speed map and a corresponding set of acoustic attenuation parameter values of the acoustic attenuation map, the stiffness map representing the distribution of the stiffness parameter across the region; and at a display in communication with the computer processor, rendering a stiffness image of the volume of tissue, based upon the stiffness map.

Abstract: This application presents a system and related methods that analyze a volume of tissue using ultrasound waveform tomography imaging. By using frequency-domain waveform tomography techniques and a gradient descent algorithm, the system can reconstruct the sound speed distributions of a volume of tissue, such as breast tissue, of varying densities with different types of lesions. By allowing sound speed to have an imaginary component that characterizes sound attenuation, the system can classify the different types of lesions with a fine granularity.

Abstract: A method and device are provided for determining a mode of detection of an element that reflects ultrasonic waves, wherein it comprises at least the following steps: For each point P of a given volume Zr, determining an ultrasonic field value Aijm (P) for N emitter-receiver pairs (i, j) and for one detection mode m, computing a number C m ? ( P , n ? ) = ? i , j = 1 N ? ? c ij m ? ( P , n ? ) of reflections of the wave where c ij m = { 1 if ? ? ? n ? ij m ? ( P ) · n ? ? = 1 0 if ? ? not with {right arrow over (n)}ijm(P) the normal formed by the “forward” direction {right arrow over (d)}i and the “backward” direction {right arrow over (d)}j of the ultrasonic wave emitted and reflected by the reflecting element, computing the energy value Em(P,{right arrow over (n)}) for each point P of the zone Zr, with {right arrow over (n)} and for a plurality of modes m with E m ? ( P , n ? ) = ? i , j = 1

Abstract: A method and system for generating an enhanced image of a volume of tissue, the method comprising: emitting acoustic waveforms toward the volume of tissue; detecting a set of acoustic signals derived from acoustic waveforms interacting with the volume of tissue; generating, from the set of acoustic signals, an initial model representing a distribution of an acoustomechanical parameter across a region of the volume of tissue; extracting a set of frequency components, from the set of acoustic signals; generating a first simulated wavefield with a first frequency component of the set of frequency components; generating an updated model of the initial model with the first simulated wavefield; iteratively refining the updated model with a set of simulated wavefields associated with the set of frequency components until a threshold condition is satisfied, thereby producing a final model; and generating the enhanced image from the final model of the volume of tissue.

Abstract: A system and method for optimising the preparation of dental restorations is provided. The system comprises a dental restoration surface processing unit, a dental restoration assessment unit, a database comprising a treatment parameters database and a processing protocols database, a processor operationally coupled to said dental restoration surface processing unit and a protocol selector. The method treats a dental restoration surface using the system and according to one or more selected processing protocol.

Abstract: A method and device are provided for determining a mode of detection of an element that reflects ultrasonic waves, wherein it comprises at least the following steps: For each point P of a given volume Zr, determining an ultrasonic field value Aijm (P) for N emitter-receiver pairs (i, j) and for one detection mode m, computing a number C m ? ( P , n ? ) = ? i , j = 1 N ? ? c ij m ? ( P , n ? ) of reflections of the wave where c ij m = { 1 if ? ? ? n ? ij m ? ( P ) · n ? ? = 1 0 if ? ? not with {right arrow over (n)}ijm(P) the normal formed by the “forward” direction {right arrow over (d)}i and the “backward” direction {right arrow over (d)}j of the ultrasonic wave emitted and reflected by the reflecting element, computing the energy value Em(P,{right arrow over (n)}) for each point P of the zone Zr, with {right arrow over (n)} and for a plurality of modes m with E m ? ( P , n ? ) = ? i , j = 1

Abstract: A method and system for analyzing stiffness in a volume of tissue, the method including: emitting acoustic waveforms toward the volume of tissue with an array of ultrasound transmitters; detecting, with an array of ultrasound receivers, a set of acoustic signals derived from acoustic waveforms transmitted through the volume of tissue; generating, from the set of acoustic signals, a sound speed map and an acoustic attenuation map of a region of the volume of tissue, generating a stiffness map derived from combination of a set of sound speed parameter values of the sound speed map and a corresponding set of acoustic attenuation parameter values of the acoustic attenuation map, the stiffness map representing the distribution of the stiffness parameter across the region; and at a display in communication with the computer processor, rendering a stiffness image of the volume of tissue, based upon the stiffness map.

Abstract: A method and system for analyzing stiffness in a volume of tissue, the method including: emitting acoustic waveforms toward the volume of tissue with an array of ultrasound transmitters; detecting, with an array of ultrasound receivers, a set of acoustic signals derived from acoustic waveforms transmitted through the volume of tissue; generating, from the set of acoustic signals, a sound speed map and an acoustic attenuation map of a region of the volume of tissue, generating a stiffness map derived from combination of a set of sound speed parameter values of the sound speed map and a corresponding set of acoustic attenuation parameter values of the acoustic attenuation map, the stiffness map representing the distribution of the stiffness parameter across the region; and at a display in communication with the computer processor, rendering a stiffness image of the volume of tissue, based upon the stiffness map.

Abstract: This application presents a system and related methods that analyze a volume of tissue using ultrasound waveform tomography imaging. By using frequency-domain waveform tomography techniques and a gradient descent algorithm, the system can reconstruct the sound speed distributions of a volume of tissue, such as breast tissue, of varying densities with different types of lesions. By allowing sound speed to have an imaginary component that characterizes sound attenuation, the system can classify the different types of lesions with a fine granularity.

Abstract: A method for manufacturing a dental restoration pre-form for use in a making a dental prosthesis is disclosed comprising providing a design of the prosthesis and a protocol for manufacturing the prosthesis and producing a dental restoration material pre-form having three dimensional (3D) characteristics based on said design of the prosthesis and steps of the protocol. There is also disclosed a method for manufacturing a dental prosthesis comprising providing dental restoration material pre-form having an associated 3D digital map, the 3D map comprising information on a spatial distribution of characteristics of the pre-form; and processing the pre-form according to a processing protocol the protocol based on a design of the prosthesis and the 3D map of the pre-form.

Abstract: A method and system for imaging a volume of tissue and defining a tissue boundary comprising: receiving a baseline dataset representative of a first set of signals interacting with a medium; receiving a reconstruction dataset representative of a second set of signals interacting with the medium and the volume of tissue present in the medium; determining a set of direct emitter-receiver pairs, each defining a direct trajectory that does not pass through the volume of tissue; from the set of direct emitter-receiver pairs, determining a set of tangential emitter-receiver pairs, each defining a bounding vector comprising a tangent point along the tissue boundary; determining a set of interior pixels, of the reconstruction dataset, characterized by a set of pixel locations within the tissue boundary; and reconstructing pixels of the set of interior pixels, thereby transforming the baseline and the reconstruction datasets into an image rendering of the volume of tissue.

Abstract: A system and method for optimising the preparation of dental restorations is provided. The system comprises a dental restoration surface processing unit, a dental restoration assessment unit, a database comprising a treatment parameters database and a processing protocols database, a processor operationally coupled to said dental restoration surface processing unit and a protocol selector. The method treats a dental restoration surface using the system and according to one or more selected processing protocol.

Abstract: The actuated leg prosthesis comprises a knee member, a socket connector provided over the knee member, an elongated trans-tibial member having a bottom end under which is connected an artificial foot, and a linear actuator. A first pivot assembly allows to operatively connect the trans-tibial member to the knee member. A second pivot assembly allows to operatively connect an upper end of the actuator to the knee member. A third pivot assembly allows to operatively connect a bottom end of the actuator to the bottom end of the trans-tibial member. The prosthesis can be provided as either a front actuator configuration or a rear actuator configuration.

Abstract: A method and system for generating an enhanced image of a volume of tissue, the method comprising: emitting acoustic waveforms toward the volume of tissue; detecting a set of acoustic signals derived from acoustic waveforms interacting with the volume of tissue; generating, from the set of acoustic signals, an initial model representing a distribution of an acoustomechanical parameter across a region of the volume of tissue; extracting a set of frequency components, from the set of acoustic signals; generating a first simulated wavefield with a first frequency component of the set of frequency components; generating an updated model of the initial model with the first simulated wavefield; iteratively refining the updated model with a set of simulated wavefields associated with the set of frequency components until a threshold condition is satisfied, thereby producing a final model; and generating the enhanced image from the final model of the volume of tissue.

Abstract: A method and system for analyzing stiffness in a volume of tissue, the method including: emitting acoustic waveforms toward the volume of tissue with an array of ultrasound transmitters; detecting, with an array of ultrasound receivers, a set of acoustic signals derived from acoustic waveforms transmitted through the volume of tissue; generating, from the set of acoustic signals, a sound speed map and an acoustic attenuation map of a region of the volume of tissue, generating a stiffness map derived from combination of a set of sound speed parameter values of the sound speed map and a corresponding set of acoustic attenuation parameter values of the acoustic attenuation map, the stiffness map representing the distribution of the stiffness parameter across the region; and at a display in communication with the computer processor, rendering a stiffness image of the volume of tissue, based upon the stiffness map.