Abstract: The present disclosure provides metabolites of belumosudil and uses of the metabolites in of treating patients with ROCK2-mediated diseases including cGVHD.

Abstract: The present disclosure provides metabolites of belumosudil and uses of the metabolites in of treating patients with ROCK2-mediated diseases including cGVHD.

Abstract: The present disclosure relates to the co-administration of Belumosudil with CYP3A Inducers and/or Proton Pump Inhibitors for use in the treatment of subjects with chronic graft-versus-host disease (cGVHD).

Abstract: The present disclosure relates generally to the treatment of patients with chronic graft-versus-host disease (cGVHD) following allogeneic hematopoietic stem cell transplantation by administering belumosudil at certain dosages.

Abstract: A connection mechanism including a plurality of microstructure features. The connection mechanism includes a first strip, with a plurality of protrusions extending from the first strip, and a second strip, with a plurality of protrusions extending from the second strip. The protrusions define grooves between adjacent protrusions. A pressure sensitive adhesive is provided in at least some of the grooves. When the first and second strips are brought together, the protrusions from one strip are received in the grooves of the other, and some of the protrusions contact the pressure sensitive adhesive, thereby connecting the first and second strips. The connection mechanism can be used as a closure mechanism for a plastic storage bag.

Abstract: A wall covering, a method of producing it and a method of covering a wall. The wall covering comprises a planar substrate, such as a nonwoven base substrate, having a front, and a back facing opposite the front. There is a barrier layer on the back of the substrate and an adhesive layer superimposed on the barrier layer. The adhesive layer comprises a first polymer component, a second polymer component, the first polymer component being a non crosslinked polymer and said second polymer component being a crosslinked polymer exhibiting properties of superabsorbency. The adhesive exhibits when exposed to water, a strength sufficient for binding to a wall substrate and a glide resistance low enough for allowing repositioning of the wall cover by sliding the wallcover on the wall without having to lift it up over a period of time of at least 5 minutes.

Abstract: Payload container and system for delivering a payload to a wellbore, the payload container includes a blister container having a cavity formed therein and an edge about the perimeter of the cavity, one or more payload substances contained within the cavity, a lidding material to cover the cavity, and optionally, an adhesive to bond the lidding material to the edge of the cavity, so that the one or more payload substances can be released in response to an external stimulus. The wellbore payload delivery system includes a plurality of payload containers and a pump system for injecting the one or more payload containers into a wellbore, the pump system has a pump and a length of tubing coupled with the pump and extending to a zone of a subterranean formation adjacent to the wellbore.

Abstract: Compositions, methods, and systems including an encapsulated additive comprising a treatment fluid additive at least partially encapsulated by an encapsulating material. The encapsulated additive has a target release profile for release of the treatment fluid additive from the encapsulating material in a specific wellbore environment. The encapsulating material is selected to achieve the target release profile, the target release profile being based on one or more conditions selected from the group consisting of: (1) a target anisotropic pressure that is greater than both an injection anisotropic pressure and an injection isotropic pressure, (2) an erosion number, (3) a temperature-driven degradation, (4) a pressure-driven degradation, (5) an amphiphilic water dispersibility, (6) an amphiphilic oil dispersibility, (7) a chemical flood degradation, (8) a water ingress value, and, (9) a radiation-driven degradation.

Abstract: A method for improving wear control in an engine or other mechanical component lubricated with a lubricating oil by using as the lubricating oil a formulated oil. The formulated oil has a composition including a lubricating oil base stock as a major component, and encapsulated boron-containing microscale particles, as a minor component. The minor component preferably contains no metal or sulfur, and preferably no phosphorus. The encapsulated boron-containing microscale particles include an encapsulating material and a boron-containing compound encapsulated by the encapsulating material. The boron-containing compound is a boron oxide, a boric acid, or mixtures thereof. The encapsulating material is a carboxylic acid selected from an aliphatic carboxylic acid, a cycloaliphatic carboxylic acid, an aromatic carboxylic acid, and mixtures thereof. The lubricating oils are useful in internal combustion engines.

Abstract: A method for improving wear control in an engine or other mechanical component lubricated with a lubricating oil by using as the lubricating oil a formulated oil. The formulated oil has a composition including a lubricating oil base stock as a major component, and encapsulated microscale particles, as a minor component. The minor component contains no sulfur or phosphorus. The encapsulated microscale particles include an encapsulating material and a core material encapsulated by the encapsulating material. The core material includes at least one metal salt selected from a metal oxide, metal hydroxide, metal carbonate, or mixtures thereof. The encapsulating material is derived from a carboxylic acid selected from an aliphatic carboxylic acid, a cycloaliphatic carboxylic acid, an aromatic carboxylic acid, and mixtures thereof. The lubricating oils are useful in internal combustion engines.

Abstract: Payload container and system for delivering a payload to a wellbore, the payload container includes a blister container having a cavity formed therein and an edge about the perimeter of the cavity, one or more payload substances contained within the cavity, a lidding material to cover the cavity, and optionally, an adhesive to bond the lidding material to the edge of the cavity, so that the one or more payload substances can be released in response to an external stimulus. The wellbore payload delivery system includes a plurality of payload containers and a pump system for injecting the one or more payload containers into a wellbore, the pump system has a pump and a length of tubing coupled with the pump and extending to a zone of a subterranean formation adjacent to the wellbore.

Abstract: A method for improving wear control in an engine or other mechanical component lubricated with a lubricating oil by using as the lubricating oil a formulated oil. The formulated oil has a composition including a lubricating oil base stock as a major component, and encapsulated boron-containing microscale particles, as a minor component. The minor component preferably contains no metal or sulfur, and preferably no phosphorus. The encapsulated boron-containing microscale particles include an encapsulating material and a boron-containing compound encapsulated by the encapsulating material. The boron-containing compound is derived from a boron powder, a boron alkoxide, a boron oxide, a boric acid, a borane, or mixtures thereof. The encapsulating material is derived from a carboxylic acid selected from an aliphatic carboxylic acid, a cycloaliphatic carboxylic acid, an aromatic carboxylic acid, and mixtures thereof. The lubricating oils are useful in internal combustion engines.

Abstract: A method for improving wear control in an engine or other mechanical component lubricated with a lubricating oil by using as the lubricating oil a formulated oil. The formulated oil has a composition including a lubricating oil base stock as a major component, and encapsulated microscale particles, as a minor component. The minor component contains no sulfur or phosphorus. The encapsulated microscale particles include an encapsulating material and a core material encapsulated by the encapsulating material. The core material includes at least one metal salt selected from a metal oxide, metal hydroxide, metal carbonate, or mixtures thereof. The encapsulating material is derived from a carboxylic acid selected from an aliphatic carboxylic acid, a cycloaliphatic carboxylic acid, an aromatic carboxylic acid, and mixtures thereof. The lubricating oils are useful in internal combustion engines.

Abstract: A compound of formula A having improved non-specific binding characteristics and pharmacokinetic properties is provided: or a pharmaceutically acceptable salt, stereoisomer, or hydrate thereof.

Abstract: A connection mechanism including a plurality of microstructure features. The connection mechanism includes a first strip, with a plurality of protrusions extending from the first strip, and a second strip, with a plurality of protrusions extending from the second strip. The protrusions define grooves between adjacent protrusions. A pressure sensitive adhesive is provided in at least some of the grooves. When the first and second strips are brought together, the protrusions from one strip are received in the grooves of the other, and some of the protrusions contact the pressure sensitive adhesive, thereby connecting the first and second strips. The connection mechanism can be used as a closure mechanism for a plastic storage bag.

Abstract: The present invention relates to methods of modulating the pharmacokinetic and/or pharmacodynamic properties of a compound by attaching at least one functional unit or group to the compound, thereby improving its non-specific binding characteristics and/or pharmacokinetic properties. Compounds comprising at least one functional residue are provided, as are pharmaceutical compositions comprising said compounds.

Abstract: A compound of formula A having improved non-specific binding characteristics and pharmacokinetic properties is provided: or a pharmaceutically acceptable salt, stereoisomer, or hydrate thereof.

Abstract: A compound of formula A having improved non-specific binding characteristics and pharmacokinetic properties is provided: or pharmaceutically acceptable salt, stereoisomer, or hydrate thereof, wherein R1 is lower alkyl, R2 and R3 are independently selected from lower alkyl, and lower alkenyl and lower alkynyl, wherein the lower alkyl, lower alkenyl, and lower alkynyl may be optionally substituted with one or more halogen, lower alkoxy, hydroxy, CN, NO2, amino, acylamino, amido, carbonyl, and alkylthio, A is N or C—H, B is N, C—H, C—(SO2—R4), or C—CO—R4, D is N, C—H, C—(SO2—R4) or C—CO—R4, E is N or C—H, wherein only one of A, B or E may be N, and one of B or D is C—(SO2—R4) or C—CO—R4, R4 is a group having the formula: in which each R5, R6, R7 and R8 are independently selected from H and lower alkyl, wherein the lower alkyl may be optionally substituted with one or more halogen, lower alkoxy, hydroxy, CN, NO2, amino, acylamino, amido, carbonyl, and alkylthio; and additionally or alternatively R6 and R5

Abstract: A deformable stamp for patterning a surface. The stamp can be placed in contact with an entire 3-dimensional object, such as a rod, in a single step. The stamp can also be used to pattern the inside of a tube or rolled over a surface to form a continuous pattern. The stamp may also be used for fluidic patterning by flowing material through channels defined by raised and recessed portions in the surface of the stamp as it contacts the substrate. The stamp may be used to deposit self-assembled monolayers, biological materials, metals, polymers, ceramics, or a variety of other materials. The patterned substrates may be used in a variety of engineering and medical applications.

Abstract: Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the flat surface, then removed to yield a flat surface that facilitates the performance of processes on and/or detection of the immobilized material.