Abstract: Compounds having the structure of Formula (I): and pharmaceutically acceptable salts thereof, wherein X1, R1, R2, R3, R4, R5 and R6 are as defined in the specification; pharmaceutical compositions comprising such compounds and salts; use of such compounds and salts to treat or prevent Prolyl endopeptidase fibroblast activation protein (FAP)-mediated conditions; kits comprising such compounds and salts; and methods for manufacturing such compounds and salts.

Abstract: Compounds having the structure of Formula (I): and pharmaceutically acceptable salts thereof, wherein X1, R1, R2, R3, R4, R5 and R6 are as defined in the specification; pharmaceutical compositions comprising such compounds and salts; use of such compounds and salts to treat or prevent Prolyl endopeptidase fibroblast activation protein (FAP)-mediated conditions; kits comprising such compounds and salts; and methods for manufacturing such compounds and salts.

Abstract: There is provided compounds of formula I wherein R1, Rx, Y, Ry, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.

Abstract: There is provided compounds of formula I wherein R1, Rx, Y, Ry, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.

Abstract: There is provided compounds of formula I 1

Abstract: There is provided compounds of formula I wherein R1, Rx, Y, Ry, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.

Abstract: There is provided compounds of formulae I and IA wherein Y, R1, R2, R3, D1 and D2 have meanings given in the description which are useful as, or as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.

Abstract: There is provided compounds of formulae I and IA 1

Abstract: There is provided compounds of formula I, wherein R1, Rx, Y, Ry, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.

Abstract: There is provided compounds of formula I, 1

Abstract: There is provided compounds of formula I, wherein R1, R2, R3, Rx, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.

Abstract: There is provided compounds of formula I, 1

Abstract: There is provided compounds of formula I, wherein R1, Rx, Y, Ry, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.

Abstract: A method and arrangement for testing the serviceability and for setting and calibrating a test apparatus for the non-destructive electrical and/or magnetic testing of metallic blanks, particularly steel slabs, for defects, such as surface or below-surface cracks, laps, shrinkholes, blowholes or the like, comprising inspecting means capable of detecting defects such as these and mounted for displacement relative to the surface of the blank to be tested, test plate simulating a defective metallic blank being brought up to the test apparatus in a position in which they are in substantial alignment with the surface of the blank to be tested, the inspecting means of the test apparatus being tested by the test plates for working order and calibrated.

Abstract: Method and apparatus for producing metal blanks, in particular steel slabs, which at least in a predetermined surface area have substantially no defects such as cracks, seams, bubbles, scabs, or the like, at least the surface portion to be made free of defects being systematically and substantially completely scanned by means of at least one inspecting device which detects such defects at and closely beneath the surface as regards location and depth and a working means being controlled by means of the recorded defects, which by scarfing, grinding, milling, planning and/or another cutting machine and/or local material melt deposition and/or material replacement or the like removes the defects detected, the defects being recorded with their depth for surface sub-areas whose width transversely of the working means is substantially equal or less than the smallest working width of the working means and the working depth of the working means being controlled in accordance with the maximum defect depth recorded for

Abstract: Method and apparatus for producing metal blanks, in particular steel slabs, which at least in a predetermined surface area have substantially no defects such as cracks, seams, bubbles, scabs, or the like, at least the surface portion to be made free of defects being systematically and substantially completely scanned by means of at least one inspecting device which detects such defects at and closely beneath the surface as regards location and depth and a working means being controlled by means of the recorded defects, which by scarfing, grinding, milling, planing and/or another cutting machine and/or local material melt deposition and/or material replacement or the like removes the defects detected, the defects being recorded with their depth for surface sub-areas whose width transversely of the working means is sustantially equal or less than the smallest working width of the working means and the working depth of the working means being controlled in accordance with the maximum defect depth recorded for th

Abstract: Method and apparatus for producing metal blanks, in particular steel slabs, which at least in a predetermined surface area have substantially no defects such as cracks, seams, bubbles, scabs, or the like, at least the surface portion to be made free of defects being systematically and substantially completely scanned by means of at least one inspecting device which detects such defects at and closely beneath the surface as regards location and depth and a working means being controlled by means of the recorded defects, which by scarfing, grinding, milling, planing and/or another cutting machine and/or local material melt deposition and/or material replacement or the like removes the defects detected, the defects being recorded with their depth for surface sub-areas whose width transversely of the working means is substantially equal or less than the smallest working width of the working means and the working depth of the working means being controlled in accordance with the maximum defect depth recorded for t

Abstract: Apparatus for non-destructive testing of metal blanks, in particular steel slabs, flat steel, billets or blooms, for defects such as cracks, seams, cavities, bubbles or the like disposed at or near the surface comprising one or more inspecting heads movable relatively to the surface of the test objects and provided with inspecting means for detecting such defects, said inspecting heads being held by means of pressure and tension members which are carried by a common support arm and transmit the pressure and tension forces substantially separately from each other so as to be individually movable up and down perpendicularly to the slab surface and constrained to move in the travelling direction in engagement with the slab surface.