Abstract: Process for bulk autoclaving of polysaccharides, wherein the process includes: a) dissolving the polysaccharides in an aqueous solution and mixing until a homogeneous solution is obtained; b) filling the resulting solution in at least one container; c) placing the filled container(s) including the solution in an autoclave; d) placing a sensor in at least one of the containers; and e) autoclaving the filled containers.

Abstract: A device for dispensing at least two mutually reactive components, such as fibrinogen and thrombin, comprising a supplier (12A, 12B) having a primary channel for supplying a respective one of said at least two reactive components to a dispenser (14) having secondary channels (18A, 18B) for separately discharging said components at a distal end orifice thereof opening into a target area for external intimate mixing of the respective reactive components outside a distal tip end of said dispenser (14). A distributor (38, 40) is interposed between said supplier and said dispenser for multiplying the number of the respective primary channels with at least a factor 2. Adjacent ones of said secondary channels (18A, 18B) are adjoined to primary channels (32, 34) intended for supply of reactive components of different kind.

Abstract: A dispenser comprising at least two parallel, hollow cylinders for supplying different mutually reactive components to a mixing device located downstream of the cylinders. The dispenser comprises a respective first piston moveable in each of the cylinders and displaceable by a piston rod connected to the respective piston. A component for actuating the pistons rods to perform a forward stroke of the pistons in their respective cylinders for dispensing an amount of the reactive components to the mixing device comprises at least one rotatable member biased in a rotational direction by a torsion spring, and at least one flexible string attached to the rotatable member and to an element connected to the piston rods. A manually operable brake member is arranged to normally act on the rotatable member to hold it still, but, when deactivated, adapted to release the rotatable member thereby causing the pistons to dispense the reactive components to the mixing device.

Abstract: A dispenser comprising at least two parallel, hollow cylinders for supplying different mutually reactive components to a mixing device located downstream of said cylinders. The dispenser comprises a respective first piston moveable in each of the cylinders and displaceable by a piston rod connected to the respective piston. A means for actuating the pistons rods to perform a forward stroke of the pistons in their respective cylinders for dispensing an amount of said reactive components to the mixing device comprises at least one rotatable member biased in a rotational direction by a torsion spring, and at least one flexible string attached to the rotatable member and to an element connected to the piston rods. A manually operable brake member is arranged to normally act on the rotatable member to hold it still, but, when deactivated, adapted to release the rotatable member thereby causing the pistons to dispense the reactive components to the mixing device.

Abstract: Process for bulk autoclaving of polysaccharides, wherein the process includes: a) dissolving the polysaccharides in an aqueous solution and mixing until a homogeneous solution is obtained; b) filling the resulting solution in at least one container; c) placing the filled container(s) including the solution in an autoclave; d) placing a sensor in at least one of the containers; and e) autoclaving the filled containers.

Abstract: A device for dispensing at least two mutually reactive components, such as fibrinogen and thrombin, comprising a supplier (12A, 12B) having a primary channel for supplying a respective one of said at least two reactive components to a dispenser (14) having secondary channels (18A, 18B) for separately discharging said components at a distal end orifice thereof opening into a target area for external intimate mixing of the respective reactive components outside a distal tip end of said dispenser (14). A distributor (38, 40) is interposed between said supplier and said dispenser for multiplying the number of the respective primary channels with at least a factor 2. Adjacent ones of said secondary channels (18A, 18B) are adjoined to primary channels (32, 34) intended for supply of reactive components of different kind.

Abstract: The invention relates to an injection device for injecting a selectable dose of a liquid substance from an ampoule, located in an ampoule holder, comprising a piston and a sleeve-shaped mechanism holder, mechanically coupled thereto, in the interior of which a longitudinally shiftable shaft is provided which acts on the ampoule.

Abstract: A multi-chamber ampoule comprises a container having at least one movable partition therein, the movable partition being adapted to sealingly isolate at least two substances to be mixed with each other, a seal or plunger movably disposed in the container, a holder connected to the container, and a screw actuator engageable with the seal or plunger for displacing the same in the container. The screw actuator has a male thread, and the holder includes a female thread engageable with the screw actuator male thread. The screw actuator is provided with a bore therethrough for slidably receiving a dispensing rod.

Abstract: The invention relates to an injection device for injecting a selectable dose of a liquid substance from an ampoule (2), located in an ampoule holder (1), comprising a piston (12) and a sleeve-shaped mechanism holder (3), mechanically coupled thereto, in the interior of which a longitudinally shiftable shaft (4) is provided which acts on the ampoule (2), the shaft (4) being surrounded by an also longitudinally shiftable advancing sleeve (5), mechanically coupled thereto, which in its upper end area is closed by a lid (7). For selecting a dose of the liquid substance to be injected, a dosing sleeve (6) with a stepped member (13) is provided, which is disposed on the mechanism holder (3) in its upper end area, the dose to be respectively administered being adjustable by a rotation of the dosing sleeve (6) with the stepped member (13).

Abstract: An injection device for injecting a preselectable dose of a liquid substance from an ampoule (2) with a stopper (12) located in an ampoule-holder (1) has a sleeve-shaped mechanism holder (3) mechanically linked to the stopper (12) and containing a sliding rod (4) which acts on the ampoule (2). The sliding rod (4) is surrounded by a sliding sleeve (5) mechanically coupled to the ampoule (2) and closed at its upper end by a lid (7). A dosing sleeve (13) is provided with a stepped member (13) arranged at the upper end of the mechanism holder (3) to preselect the dose of liquid substance to be injected. The dose to be administered can be adjusted by turning the dosing sleeve (6) provided with the stepped member (13).

Abstract: A device for displacing a plunger (35), movably disposed in a container (23), e.g. a medical multi-chamber ampoule, which has at least one movable partition (29), sealingly isolating at least two substances to be mixed with each other, comprises a holder means (6) for releasable connection to the container (23), a screw actuator (4) engageable with the plunger (37) for displacing it in the container (23), the holder means (6) further having a female thread, engageable with the corresponding male thread of the screw actuator. The female thread is divided into at least two parts, which are movable between a first position, in which the parts of the female thread are not engageable with the screw actuator, and a second position, in which the parts of the female thread are engageable with the actuator. The bolder means (8) has actuating means for moving the female read parts between said first and second positions.

Abstract: An injection cartridge of the dual-chamber type, which comprises a cylindrical cartridge barrel having a front chamber for a solid product and a rear chamber for a liquid product. The chambers are sealingly separated by a displaceable piston of a resilient material, and have an openable bypass connection for liquid from the rear chamber to the front chamber and a resilient sealing closure of the front end of the front chamber.

Abstract: An injection cartridge is disclosed which has provision for the after injection of a rinsing solution to wash off the medicament that is first injected. The novel cartridge has a forward compartment and a rearward compartment, each having a piston disposed rearwardly thereof. A by-pass conduit is provided at the forward end of the cartridge which is longer than the thickness of the forwardmost piston. A medicament is positioned in the forward compartment and a rinsing solution is positioned in the rearward compartment. Moving the rearward piston forward forces the rinsing solution against the forward piston which in turn forces the medicament forward and expels it from the forward compartment. After the forward piston has reached its forward stop, the forward by-pass becomes open to the rearward compartment and continued forward movement of the rearward piston causes the rinsing solution to be forced through the forward by-pass and out the outlet end of the cartridge.

Abstract: A piston (11) to be used in displacing a liquid inside a cylindrical chamber, such as in an injection cartridge of the dual-chamber type, has at least one of its end surfaces (12) shaped convex such that said end surface or surfaces (12) are essentially planar when the piston has been arranged inside the barrel of said cartridge. Preferably both pistons in the cartridge have such a shape, their planar surfaces facing each other.

Abstract: A liquid preparation of a pharmaceutically active agent having a defined composation is repeatedly dosed from a multi-dose container having a defined volume. The amount dosed is selected as 1/N of the volume of the multi-dose container, N being an integer having a value of 2 or higher.A device for dosing a liquid preparation comprises a holder (1) for a multi-dose container (2), which has a movable rear wall (5) acting as a piston for expelling the liquid preparation (6) from the container, and a piston rod (7), which is provided with releasable blocking means (11, 14, 19, 22), such that the movement of the piston rod is limited to a preset length (35) corresponding to an expelled volume of 1/N of the volume of said multi-dose container, N being an integer having a value of 2 or higher.A preferred embodiment of the device is as an injection device for repeated parenteral injections from an injection cartridge.

Abstract: A method for manufacturing an injectable preparation of a pharmaceutically active agent suitable for storage in a dual-chamber injection cartridge. A dual chamber injection cartridge is provided, including: a barrel; a front chamber for a solid component; a rear chamber for a liquid component; a displaceable front piston separating the front and rear chambers; a closure sealing the front end of the barrel; and a constriction between the front and rear ends of the barrel. The constriction has a non-circular cross-section and an openable bypass connection permitting passage of liquid between the rear and front chambers. Prior to opening the bypass connection, the front piston is positioned between the constriction and the rear end of the barrel. The constriction resists displacement of the front piston in a direction of the front end of the barrel when the piston is in the vicinity of the constriction.

Abstract: A medicine dispensing device including a slotted housing, a front end, a rear end, at least one threaded portion in the vicinity of the rear end, a dosage ampoule fitting in the vicinity of the front end and a discharge conduit for connection with a discharge ampoule. A hollow screw-threaded device receives the ampoule therein. The screw-threaded device is received by the rear end of the housing. The screw-threaded device includes an exterior surface provided with a threaded surface engaging the at least one threaded portion for securing the ampoule within the housing. A medicine discharge and metering device for metering and discharging the contents of the ampoule is received within the screw-threaded device and is movable in a direction of a longitudinal axis thereof.

Abstract: A device for an injection apparatus, including a dual-chamber injection cartridge. The cartridge includes a front end, a rear end, a front opening in the vicinity of a front end of the cartridge, a front chamber located in the vicinity of the front opening and including a drug freeze-dried in the front chamber, a rear chamber including a liquid component, a movable wall separating the front chamber and the rear chamber, a bypass for transferring the liquid component between the front chamber and the rear chamber, and a rear piston. The cartridge is slidably arranged within a cylindrical sleeve substantially the same length as the cartridge. A stopper is located in the vicinity of the front opening of the cartridge. The stopper is directed rearwardly coaxially with the cartridge, wherein as the sleeve is displaced rearwardly after the freeze-drying of the drug, the stopper enters the front opening of the cartridge to sealingly close the cartridge.

Abstract: Device and method for dosing a liquid product from a tubular container are provided. The container includes a plurality of doses of the liquid product and a plate for pinching the container together locally such that it is divided into a plurality of separate liquid chambers containing a desired dose.