Patents by Inventor Om NARAYAN

Om NARAYAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process of storing and preparing the protein
    Patent number: 12760062
    Abstract: The present invention provides a method for reducing the protein aggregation by adjusting the pH below 6.0 of liquid formulation comprising the antibody or fusion protein. The present invention also provides methods for storing the pre-formulation for longer period without using any sugar or additives which can be utilized for preparation of liquid or lyophilized formulation.
    Type: Grant
    Filed: May 28, 2021
    Date of Patent: October 13, 2026
    Assignee: Kashiv BioSciences, LLC
    Inventors: Om Narayan, Tarun Kumar Gupta, Mayankkumar Thakkar, Kishor Galani
  • PROCESS OF AFFINITY CHROMATOGRAPHY
    Publication number: 20260295463
    Abstract: A process for purification of antibody or fusion protein by affinity chromatography wherein the elution is performed with high salt concentration which reduce turbidity in protein mixture during neutralization steps. The present invention provides an improved process of purifying antibodies through affinity chromatography using high salt-based elution.
    Type: Application
    Filed: June 8, 2026
    Publication date: October 1, 2026
    Inventors: Om Narayan, Tarun Kumar Gupta, Mayankkumar Thakkar
  • PROCESS OF PURIFICATION OF PROTEIN
    Publication number: 20260258078
    Abstract: The invention provides a process of purification of antibody or fusion protein from protein mixture comprising product and process related impurities. The process provides the use of hydroxyapatite chromatography for the separation of low molecular weight impurities and basic variants. In addition, invention further provides a scalable purification process to remove product and process related impurities.
    Type: Application
    Filed: April 23, 2026
    Publication date: September 3, 2026
    Inventors: Om Narayan, Tarun Kumar Gupta, Mayankkumar Thakkar
  • IMPROVED PROCESS OF PURIFICATION OF PROTEIN
    Publication number: 20260242412
    Abstract: The invention provides a process of purification of antibody or fusion protein from protein mixture comprising product and process related impurities. The process provides the use of hydroxyapatite chromatography for the separation of low molecular weight impurities and basic variants. In addition, invention further provides a scalable purification process to remove product and process related impurities.
    Type: Application
    Filed: April 7, 2026
    Publication date: August 20, 2026
    Inventors: Om Narayan, Tarun Kumar Gupta, Mayankkumar Thakkar
  • MULTICISTRON EXPRESSION VECTOR FOR COVID-19 VACCINE
    Publication number: 20260159553
    Abstract: The present invention provides an expression vector comprises gene of interest encode more than one structural protein to enhance immune responses against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) and its variants. Furthermore, the expression vector to produce mRNA expresses more than one structural protein to generate immune response against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) and its variants.
    Type: Application
    Filed: November 3, 2022
    Publication date: June 11, 2026
    Inventors: Sudharti Gupta, Om Narayan, Narahari Ponnapu Reddy, Chandramauli Rawal
  • PROCESS OF PURIFICATION OF PROTEIN
    Publication number: 20260116917
    Abstract: The invention provides a process of purification of antibody or fusion protein from protein mixture comprising product and process related impurities. The process provides the use of hydroxyapatite chromatography for the separation of low molecular weight impurities and basic variants. In addition, invention further provides a scalable purification process to remove product and process related impurities.
    Type: Application
    Filed: December 24, 2025
    Publication date: April 30, 2026
    Inventors: Om Narayan, Tarun Kumar Gupta, Mayankkumar Thakkar
  • PROCESS OF PURIFICATION OF PROTEIN
    Publication number: 20260117000
    Abstract: A process for purification of antibody or fusion protein through anion exchange chromatography to produce an antibody or fusion protein which is substantially free of at least one of the product-related impurities.
    Type: Application
    Filed: December 24, 2025
    Publication date: April 30, 2026
    Inventors: Om Narayan, Tarun Kumar Gupta, Mayankkumar Thakkar
  • PROCESS OF PURIFICATION OF PROTEIN
    Publication number: 20260103542
    Abstract: A process for purification of antibody or fusion protein through anion exchange chromatography to produce an antibody or fusion protein which is substantially free of at least one of the product-related impurities.
    Type: Application
    Filed: May 27, 2025
    Publication date: April 16, 2026
    Inventors: Om Narayan, Tarun Kumar Gupta, Mayankkumar Thakkar
  • Process of purification of protein
    Patent number: 12600747
    Abstract: The invention provides a process of purification of antibody or fusion protein from protein mixture comprising product and process related impurities. The process provides the use of hydroxyapatite chromatography for the separation of low molecular weight impurities and basic variants. In addition, invention further provides a scalable purification process to remove product and process related impurities.
    Type: Grant
    Filed: March 27, 2025
    Date of Patent: April 14, 2026
    Assignee: Kashiv BioSciences, LLC
    Inventors: Om Narayan, Tarun Kumar Gupta, Mayankkumar Thakkar
  • PROCESS OF PURIFICATION OF PROTEIN
    Publication number: 20250353877
    Abstract: The invention provides a process of purification of antibody or fusion protein from protein mixture comprising product and process related impurities. The process provides the use of hydroxyapatite chromatography for the separation of low molecular weight impurities and basic variants. In addition, invention further provides a scalable purification process to remove product and process related impurities.
    Type: Application
    Filed: July 28, 2025
    Publication date: November 20, 2025
    Inventors: Om Narayan, Tarun Kumar Gupta, Mayankkumar Thakkar
  • Process of purification of protein
    Patent number: 12435106
    Abstract: The invention provides a process of purification of antibody or fusion protein from protein mixture comprising product and process related impurities. The process provides the use of hydroxyapatite chromatography for the separation of low molecular weight impurities and basic variants. In addition, invention further provides a scalable purification process to remove product and process related impurities.
    Type: Grant
    Filed: January 18, 2024
    Date of Patent: October 7, 2025
    Assignee: Kashiv BioSciences, LLC
    Inventors: Om Narayan, Tarun Kumar Gupta, Mayankkumar Thakkar
  • AN IMPROVED PROCESS OF PURIFICATION OF PROTEIN
    Publication number: 20250296015
    Abstract: A process for purification of antibody or fusion protein through anion exchange chromatography to produce an antibody or fusion protein which is substantially free of at least one of the product-related impurities.
    Type: Application
    Filed: June 6, 2025
    Publication date: September 25, 2025
    Inventors: Om Narayan, Tarun Kumar Gupta, Mayankkumar Thakkar
  • AN IMPROVED PROCESS OF PURIFICATION OF PROTEIN
    Publication number: 20250296014
    Abstract: A process for purification of antibody or fusion protein through anion exchange chromatography to produce an antibody or fusion protein which is substantially free of at least one of the product-related impurities.
    Type: Application
    Filed: June 6, 2025
    Publication date: September 25, 2025
    Inventors: Om Narayan, Tarun Kumar Gupta, Mayankkumar Thakkar
  • PROCESS OF PURIFICATION OF PROTEIN
    Publication number: 20250282814
    Abstract: The invention provides a process of purification of antibody or fusion protein from protein mixture comprising product and process related impurities. The process provides the use of hydroxyapatite chromatography for the separation of low molecular weight impurities and basic variants. In addition, invention further provides a scalable purification process to remove product and process related impurities.
    Type: Application
    Filed: March 27, 2025
    Publication date: September 11, 2025
    Inventors: Om Narayan, Tarun Kumar Gupta, Mayankkumar Thakkar
  • Process of purification of protein
    Patent number: 12378282
    Abstract: The invention provides a process of purification of antibody or fusion protein from protein mixture comprising product and process related impurities. The process provides the use of hydroxyapatite chromatography for the separation of low molecular weight impurities and basic variants. In addition, invention further provides a scalable purification process to remove product and process related impurities.
    Type: Grant
    Filed: September 23, 2024
    Date of Patent: August 5, 2025
    Assignee: Kashiv BioSciences, LLC
    Inventors: Om Narayan, Tarun Kumar Gupta, Mayankkumar Thakkar
  • PROCESS OF AFFINITY CHROMATOGRAPHY
    Publication number: 20250099873
    Abstract: A process for purification of antibody or fusion protein by affinity chromatography wherein the elution is performed with high salt concentration which reduce turbidity in protein mixture during neutralization steps. The present invention provides an improved process of purifying antibodies through affinity chromatography using high salt-based elution.
    Type: Application
    Filed: December 6, 2024
    Publication date: March 27, 2025
    Inventors: Om Narayan, Tarun Kumar Gupta, Mayankkumar Thakkar
  • FORMULATION OF HIGHLY CONCENTRATED PHARMACOLOGICALLY ACTIVE ANTIBODY
    Publication number: 20250043027
    Abstract: The present disclosure describes pharmaceutically stable high concentration liquid formulations of antibody. Such formulations comprise, in addition to the antibody, at least one anti-aggregating agent selected from arginine or lysine, buffer and poloxamer 188. In addition, the present disclosure provides high concentrated antibody formulation having high monomer, low aggregates and desirable viscosity.
    Type: Application
    Filed: October 25, 2024
    Publication date: February 6, 2025
    Inventors: Bruce Weaver, Om Narayan, Sumit Maheshkumar Shah
  • PROCESS OF PURIFICATION OF PROTEIN
    Publication number: 20250011395
    Abstract: The invention provides a process of purification of antibody or fusion protein from protein mixture comprising product and process related impurities. The process provides the use of hydroxyapatite chromatography for the separation of low molecular weight impurities and basic variants. In addition, invention further provides a scalable purification process to remove product and process related impurities.
    Type: Application
    Filed: September 23, 2024
    Publication date: January 9, 2025
    Inventors: Om Narayan, Tarun Kumar Gupta, Mayankkumar Thakkar
  • AN IMPROVED PROCESS FOR PURIFICATION OF FUSION PROTEIN
    Publication number: 20240400612
    Abstract: The present invention relates to purification process of pharmacologically active cytotoxic T lymphocyte-associated 4-immunoglobulin (CTLA4-lg) fusion protein by using three column chromatography steps that provides purified form of the fusion protein, substantially free of misfolded species, charge variants and aggregates. A method for purifying a fusion protein from a protein mixture comprising a fusion protein and high molecular weight (HMW) impurity.
    Type: Application
    Filed: September 28, 2022
    Publication date: December 5, 2024
    Inventors: Om Narayan, Mayankkumar Thakkar, Anuj Kumar
  • Process of purification of protein
    Patent number: 12139510
    Abstract: The invention provides a process of purification of antibody or fusion protein from protein mixture comprising product and process related impurities. The process provides the use of hydroxyapatite chromatography for the separation of low molecular weight impurities and basic variants. In addition, invention further provides a scalable purification process to remove product and process related impurities.
    Type: Grant
    Filed: January 18, 2024
    Date of Patent: November 12, 2024
    Assignee: Kashiv BioSciences, LLC
    Inventors: Om Narayan, Tarun Kumar Gupta, Mayankkumar Thakkar