Patents by Inventor Om NARAYAN

Om NARAYAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS OF PURIFICATION OF PROTEIN
    Publication number: 20240158437
    Abstract: The invention provides a process of purification of antibody or fusion protein from protein mixture comprising product and process related impurities. The process provides the use of hydroxyapatite chromatography for the separation of low molecular weight impurities and basic variants. In addition, invention further provides a scalable purification process to remove product and process related impurities.
    Type: Application
    Filed: January 18, 2024
    Publication date: May 16, 2024
    Inventors: Om Narayan, Tarun Kumar Gupta, Mayankkumar Thakkar
  • NOVEL FORMULATION OF FUSION PROTEIN
    Publication number: 20240156907
    Abstract: The present invention relates to novel liquid formulations comprising pharmacologically active fusion protein. The present invention discloses the use of histidine buffer in combination with other excipients to stabilize the fusion protein by lowering the product related impurities. In another aspects invention provides a formulation of fusion protein with low viscosity.
    Type: Application
    Filed: March 16, 2022
    Publication date: May 16, 2024
    Inventors: Om Narayan, Tarun Kumar Gupta, Kiran Suresh Avadhani, Kaushal Joshi
  • AN IMPROVED PROCESS OF STORING AND PREPARING THE PROTEIN
    Publication number: 20230348530
    Abstract: The present invention provides a method for reducing the protein aggregation by adjusting the pH below 6.0 of liquid formulation comprising the antibody or fusion protein. The present invention also provides methods for storing the pre-formulation for longer period without using any sugar or additives which can be utilized for preparation of liquid or lyophilized formulation.
    Type: Application
    Filed: May 28, 2021
    Publication date: November 2, 2023
    Inventors: Om Narayan, Tarun Kumar Gupta, Mayankkumar Thakkar, Kishor Galani
  • AN IMPROVED PROCESS OF PURIFICATION OF PROTEIN
    Publication number: 20230167153
    Abstract: The invention provides a process of purification of antibody or fusion protein from protein mixture comprising product and process related impurities. The process provides the use of hydroxyapatite chromatography for the separation of low molecular weight impurities and basic variants. In addition, invention further provides a scalable purification process to remove product and process related impurities.
    Type: Application
    Filed: May 1, 2021
    Publication date: June 1, 2023
    Inventors: Om Narayan, Tarun Kumar Gupta, Mayankkumar Thakkar
  • AN IMPROVED PROCESS OF PURIFICATION OF PROTEIN
    Publication number: 20230166200
    Abstract: A process for purification of antibody or fusion protein through anion exchange chromatography to produce an antibody or fusion protein which is substantially free of at least one of the product-related impurities.
    Type: Application
    Filed: May 1, 2021
    Publication date: June 1, 2023
    Inventors: Om Narayan, Tarun Kumar Gupta, Mayankkumar Thakkar
  • AN IMPROVED PROCESS OF AFFINITY CHROMATOGRAPHY
    Publication number: 20230166201
    Abstract: A process for purification of antibody or fusion protein by affinity chromatography wherein the elution is performed with high salt concentration which reduce turbidity in protein mixture during neutralization steps. The present invention provides an improved process of purifying antibodies through affinity chromatography using high salt-based elution.
    Type: Application
    Filed: May 1, 2021
    Publication date: June 1, 2023
    Inventors: Om Narayan, Tarun Kumar Gupta, Mayankkumar Thakkar
  • FORMULATION OF HIGHLY CONCENTRATED PHARMACOLOGICALLY ACTIVE ANTIBODY
    Publication number: 20220267473
    Abstract: The present disclosure describes pharmaceutically stable high concentration liquid formulations of antibody. Such formulations comprise, in addition to the antibody, at least one anti-aggregating agent selected from arginine or lysine, buffer and poloxamer 188. In addition, the present disclosure provides high concentrated antibody formulation having high monomer, low aggregates and desirable viscosity.
    Type: Application
    Filed: February 28, 2022
    Publication date: August 25, 2022
    Inventors: Bruce WEAVER, Om NARAYAN, Sumit Maheshkumar SHAH