Patents by Inventor Om Srivastava

Om Srivastava has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Syntheses of 4-alkyl chromogenic glycosides and 7-alkyl chromogenic glycosides of N-acetylneuraminic acids
    Patent number: 6420552
    Abstract: The present invention provides improved method of preparing a 4-O-alkyl chromogenic ketoside of N-acetylneuraminic acid (Neu5Ac) and a 7-O-alkyl chromogenic ketoside of N-acetylneuraminic acid (Neu5Ac) for use in the selective detection of various influenza viruses and parainfluenza viruses. The ketosides are substrates that are selectively cleaved by a neuraminidase on the virus to be detected, but not by neuraminidases found on other viruses or on bacteria, or on the cells of the host. The syntheses are efficient and provide large quantities of the ketosides for commercial development. The synthesis includes a step of alkylating the 4- or 7-hydroxyl groups of a protected alkyl ester alkyl ketoside derivative of Neu5Ac by processes that include contacting the derivative with a composition comprising an alkyl halide to form a 4- or a 7-O-alkyl protected alkyl ester alkyl ketoside derivative of Neu5Ac.
    Type: Grant
    Filed: August 29, 2000
    Date of Patent: July 16, 2002
    Assignee: Zymetx, Inc.
    Inventors: Om Srivastava, Geeta Srivastava, Minghui Du, Ole Hingsgaul, David R. Bundle
  • Synthesis of 4,7-dialkyl chromogenic glycosides of N-acetylneuraminic acids
    Patent number: 6303764
    Abstract: The present invention provides an improved method of preparing a 4,7-di-O-alkyl chromogenic ketoside of N-acetylneuraminic acid (Neu5Ac) for use in detecting influenza virus types A and B. The ketosides are substrates that are selectively cleaved by a neuraminidase on influenza virus, but not be neuraminidases found on other viruses or on bacteria. The synthesis is efficient and provides large quantities of the ketoside for commercial development. The synthesis includes a step of alkylating the 4- and 7-hydroxyl groups of a protected alkyl ester alkyl ketoside derivative of Neu5Ac by a process that comprises contacting the derivative with a composition comprising an alkyl halide to form a 4,7-di-O-alkyl protected alkyl ester alkyl ketoside derivative of Neu5Ac. The synthesis alternatively includes protecting the 8- and 9-hydroxyl groups of an alkyl ester alkyl ketoside derivative of Neu5Ac by forming an 8,9-epoxide protected alkyl ester alkyl ketoside derivative of Neu5Ac.
    Type: Grant
    Filed: September 24, 1999
    Date of Patent: October 16, 2001
    Assignees: Zymetx, Inc., Palladin Opportunity Fund, LLC, Halifex Fund, L.P.
    Inventors: Om Srivastava, Geeta Srivastava, Minghui Du, Ole Hindsgaul, David R. Bundle, Avraham Liav
  • Modified .alpha.-D-Glc.rho.-(1-2)-.alpha.-D-Glc.rho.-(1-3)-.alpha.-D-Glc.rho.-ana logues
    Patent number: 5929037
    Abstract: Disclosed is the trisaccharide .alpha.-D-Glcp-(1-2)-.alpha.-D-Glcp-(1-3)-.alpha.-D-Glcp and compounds related thereto as well as pharmaceutical compositions thereof.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 27, 1999
    Assignee: Alberta Research Council
    Inventors: Om Srivastava, Roman Szweda
  • Modified kojibioside analogues
    Patent number: 5877157
    Abstract: Disclosed are novel analogues of kojibiose and pharmaceutical compositions comprising such analogues.
    Type: Grant
    Filed: March 7, 1997
    Date of Patent: March 2, 1999
    Assignee: Alberta Research Council
    Inventors: Om Srivastava, Roman Szweda, Ulrike Spohr
  • Processes for the synthesis of sialyl Lewis.sup.x compounds
    Patent number: 5654412
    Abstract: Disclosed are processes for the chemical synthesis of sialyl Lewis.sup.x -Y compounds where Y is --OH, --NHR, --SH, --SR or --OR, and R is an aglycon of at least one carbon atom.
    Type: Grant
    Filed: May 29, 1996
    Date of Patent: August 5, 1997
    Assignee: Glycomed Incorporated
    Inventors: Om Srivastava, Jonathan M. Gregson
  • Modified kojibiosides analogues
    Patent number: 5633233
    Abstract: Disclosed are novel analogues of kojibiose and pharmaceutical compositions comprising such analogues.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 27, 1997
    Assignee: Alberta Research Council
    Inventors: Om Srivastava, Roman Szweda, Ulrike Spohr