Abstract: A sensor monitoring system includes a plurality of image capture devices. Each image capture device includes one or more sensors to detect image data representing an environment about the image capture device, communications circuitry to receive sensor data from a sensor device and remote sensor data including at least one of a second image of the sensor or second position data regarding the sensor device, and processing circuitry to validate the sensor device based on the sensor data, determine first position data regarding the sensor device based on at least one of the first network connection or the remote sensor data, determine that the sensor device is in an image capture range based on the first position data, retrieve one or more images of the sensor device, and generate an alert based on the first position data.

Abstract: A method for placing content in an augmented reality system. A notification is received regarding availability of new content to display in the augmented reality system. A confirmation is received that indicates acceptance of the new content. Three dimensional information that describes the physical environment is provided, to an external computing device, to enable the external computing device to be used for selecting an assigned location in the physical environment for the new content. Location information is received, from the external computing device, that indicates the assigned location. A display location on a display system of the augmented reality system at which to display the new content so that the new content appears to the user to be displayed as an overlay at the assigned location in the physical environment is determined, based on the location information. The new content is displayed on the display system at the display location.

Abstract: A gas hydrate desalination system that includes a reactor with a detachable water jacket and thermocouples. The reactor has a detachable lid having a liquid inlet, a gas inlet, sapphire glass lenses, and lid cameras. An exit concentrate channel is provided at a bottom of the reactor. A mixing unit of the system includes a liquid storage tank connected to the reactor through the liquid inlet, and a gas feed cylinder connected the reactor through the gas inlet. A resolving unit of the system includes a sieve filter column for filtering brine from gas hydrate. The sieve filter column is connected to the exit concentrate channel and a first fraction column, which is connected to a brine column. The channel is further connected to a second fraction column, which is connected to the brine column for separating freshwater from the gas hydrate.

Abstract: The present invention provides compositions and methods for detecting exhausted T cells in a subject. The present invention also provides methods for treating a subject having a disease characterized by the presence of exhausted T cells or certain subpopulations thereof.

Abstract: A method for placing content in an augmented reality system. A notification is received regarding availability of new content to display in the augmented reality system. A confirmation is received that indicates acceptance of the new content. Three dimensional information that describes the physical environment is provided, to an external computing device, to enable the external computing device to be used for selecting an assigned location in the physical environment for the new content. Location information is received, from the external computing device, that indicates the assigned location. A display location on a display system of the augmented reality system at which to display the new content so that the new content appears to the user to be displayed as an overlay at the assigned location in the physical environment is determined, based on the location information. The new content is displayed on the display system at the display location.

Abstract: Provided herein are recombinant nucleic acids encoding chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX. Also provided are systems of chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX, cells expressing such proteins and shRNA, and methods of use thereof.

Abstract: A computing resource of a cloud computing environment receives, from customers in a customer population, requests to enroll in group-based subscriptions provided by third-party providers. The requests include customer preferences associated with the customers. The computing resource determines customer account attributes for customer accounts, and determines, using a customer matching model, scores for the customers based on the customer preferences and the customer account attributes. The scores predict a successful matching among the customers in the customer population. The computing resource assigns a first subset of the customers in the customer population to a first group of customers based on the scores, enrolls the first group of customers in a first account for a first group-based subscription provided by a first third-party provider, and allocates a payment for the first group-based subscription among a first group of customer accounts associated with customers in the first group of customers.

Abstract: A video community system that provides conversation videos to a member who is one of a plurality of community members. The system can include a conversation video storage medium that stores conversation videos that are each associated with one of a plurality of thematic content events; and a member interface that couples the video community system to a plurality of user devices. The member interface receives a user request from the requesting community member for a conversation video that is associated with a particular thematic content event. In response, the video community system accesses the conversation video from the conversation video storage medium that is associated with the particular thematic content event identified in the user request. The video community system communicates the accessed conversation video and at least a portion of the particular thematic content event to the requesting community member's device for concurrent display.

Abstract: A fixation mechanism that more effectively limits or prevents relative movement between two adjacent objects includes an elongated tie having a free end and a joined end and a clasp coupled to the joined end of the tie. The clasp includes a housing having an insertion channel in which the free end of the tie is inserted and an exit channel through which the tie exits such that the tie and clasp form a loop that connects the two adjacent objects. The clasp further includes a locking mechanism positioned in the housing between the insertion channel and the exit channel. The locking mechanism includes a locking tine that permits the free end of the tine to pass forwardly through the insertion channel and out the exit channel but grips the tie to prevent it from moving rearwardly out of the housing.

Abstract: A sensor monitoring system includes a plurality of image capture devices. Each image capture device includes one or more sensors to detect image data representing an environment about the image capture device, communications circuitry to receive sensor data from a sensor device and remote sensor data including at least one of a second image of the sensor or second position data regarding the sensor device, and processing circuitry to validate the sensor device based on the sensor data, determine first position data regarding the sensor device based on at least one of the first network connection or the remote sensor data, determine that the sensor device is in an image capture range based on the first position data, retrieve one or more images of the sensor device, and generate an alert based on the first position data.

Abstract: A video community system that provides conversation videos to a member who is one of a plurality of community members. The system can include a conversation video storage medium that stores conversation videos that are each associated with one of a plurality of thematic content events; and a member interface that couples the video community system to a plurality of user devices. The member interface receives a user request from the requesting community member for a conversation video that is associated with a particular thematic content event. In response, the video community system accesses the conversation video from the conversation video storage medium that is associated with the particular thematic content event identified in the user request. The video community system communicates the accessed conversation video and at least a portion of the particular thematic content event to the requesting community member's device for concurrent display.

Abstract: Provided herein are recombinant nucleic acids encoding chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX. Also provided are systems of chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX, cells expressing such proteins and shRNA, and methods of use thereof.

Abstract: The present invention provides methods of preventing, reducing or reversing T cell exhaustion in a patient having a disease. The present invention also provides methods for treating a disease in a patient having the disease. The present invention also provides an engineered T cell, and uses thereof.

Abstract: Systems and methods of emulating a conversation about a thematic content event are disclosed. An exemplary embodiment receives a member dialogue video from a community member who is a member of a plurality of community members, wherein the member dialogue video includes video and audio portions, and wherein the member dialogue video expresses at least one of a personal opinion and a personal viewpoint about the thematic content event; generates dialogue text from the audio portion of each received member dialogue video, wherein the dialogue text comprises words and phrases spoken by the community member in the member dialogue video; receives a modified thematic content event; compares the words and phrases of the dialogue text with the plurality of keywords; and associates at least one portion of the member dialogue video having the words and phrases of the dialogue text that match with the matching keyword of the anchor point.

Abstract: A computing resource of a cloud computing environment receives, from customers in a customer population, requests to enroll in group-based subscriptions provided by third-party providers. The requests include customer preferences associated with the customers. The computing resource determines customer account attributes for customer accounts, and determines, using a customer matching model, scores for the customers based on the customer preferences and the customer account attributes. The scores predict a successful matching among the customers in the customer population. The computing resource assigns a first subset of the customers in the customer population to a first group of customers based on the scores, enrolls the first group of customers in a first account for a first group-based subscription provided by a first third-party provider, and allocates a payment for the first group-based subscription among a first group of customer accounts associated with customers in the first group of customers.

Abstract: A method for placing content in an augmented reality system. A notification is received regarding availability of new content to display in the augmented reality system. A confirmation is received that indicates acceptance of the new content. Three dimensional information that describes the physical environment is provided, to an external computing device, to enable the external computing device to be used for selecting an assigned location in the physical environment for the new content. Location information is received, from the external computing device, that indicates the assigned location. A display location on a display system of the augmented reality system at which to display the new content so that the new content appears to the user to be displayed as an overlay at the assigned location in the physical environment is determined, based on the location information. The new content is displayed on the display system at the display location.

Abstract: Nanoparticle compositions for delivery of nucleic acids to subjects including modified dendrimers comprising cores, one or more of homogeneous or heterogeneous intermediate and terminal layers, and therapeutic or immunogenic nucleic acid agents enclosed within nanop article compositions are described. Methods for treating or preventing diseases or conditions in a subject by administering the nanoparticle compositions that provide immune responses and synergistic therapeutic or preventive effects are provided.

Abstract: A computing resource of a cloud computing environment receives, from customers in a customer population, requests to enroll in group-based subscriptions provided by third-party providers. The requests include customer preferences associated with the customers. The computing resource determines customer account attributes for customer accounts, and determines, using a customer matching model, scores for the customers based on the customer preferences and the customer account attributes. The scores predict a successful matching among the customers in the customer population. The computing resource assigns a first subset of the customers in the customer population to a first group of customers based on the scores, enrolls the first group of customers in a first account for a first group-based subscription provided by a first third-party provider, and allocates a payment for the first group-based subscription among a first group of customer accounts associated with customers in the first group of customers.

Abstract: A method for placing content in an augmented reality system. A notification is received regarding availability of new content to display in the augmented reality system. A confirmation is received that indicates acceptance of the new content. Three dimensional information that describes the physical environment is provided, to an external computing device, to enable the external computing device to be used for selecting an assigned location in the physical environment for the new content. Location information is received, from the external computing device, that indicates the assigned location. A display location on a display system of the augmented reality system at which to display the new content so that the new content appears to the user to be displayed as an overlay at the assigned location in the physical environment is determined, based on the location information. The new content is displayed on the display system at the display location.

Abstract: The present invention provides methods of preventing, reversing or increasing T cell exhaustion in a patient having a disease. The present invention also provides methods for treating a disease in a patient having the disease. The present invention also provides an engineered T cell comprising a high priority epigenetic pathway that has been targeted, and uses thereof.