Patents by Inventor Omar Abdel-Rahman Ali

Omar Abdel-Rahman Ali has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Controlled delivery of TLR3 agonists in structural polymeric devices
    Patent number: 9821045
    Abstract: The present invention comprises compositions, methods, and devices for creating an stimulating an antigen-specific dendritic cell immune response. Devices and methods provide prophylactic and therapeutic immunity to subjects against cancer and infectious agents.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: November 21, 2017
    Assignees: President and Fellows of Harvard College, Dana-Farber Cancer Institute
    Inventors: Omar Abdel-Rahman Ali, Glenn Dranoff, David J. Mooney
  • Scaffolds for cell collection or elimination
    Patent number: 9770535
    Abstract: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated therein or thereon, or diffusing from the scaffold composition such that the scaffold composition and/or a bioactive composition captures and eliminates undesirable cells from the body a mammalian subject. The devices mediate active recruitment, sequestration, and removal or elimination of undesirable cells from their host.
    Type: Grant
    Filed: June 11, 2008
    Date of Patent: September 26, 2017
    Assignee: President and Fellows of Harvard College
    Inventors: David J. Mooney, Omar Abdel-Rahman Ali
  • PATHOGEN VACCINES AND METHODS OF PRODUCING AND USING THE SAME
    Publication number: 20170246281
    Abstract: The present invention provides vaccine compositions and methods of producing such compositions. Other embodiments of the invention include methods of treating a pathogen infection, methods of vaccinating a subject against a pathogen infection, and methods for treating an antibiotic-resistance bacterial infection in a subject in need thereof. In further embodiments, the invention includes methods of decreasing the level of a pathogen in a subject having a pathogen infection, methods of increasing the surviving rate of a subject having a pathogen infection, methods of reducing the level of pain associated with a pathogen infection, and methods of reducing the level of distress associated with a pathogen infection in a subject in need thereof. Novel scaffold compositions and opsonin-bound or lectin-bound pathogen compositions, and uses thereof, are also provided herein.
    Type: Application
    Filed: February 16, 2017
    Publication date: August 31, 2017
    Inventors: Michael Super, Edward J. Doherty, Mark Cartwright, Des White, Alexander G. Stafford, Omar Abdel-Rahman Ali, Amanda Graveline, Donald E. Ingber, David J. Mooney, Benjamin Seiler
  • Combination Vaccine Devices and Methods of Killing Cancer Cells
    Publication number: 20170042995
    Abstract: The present invention comprises compositions, methods, and devices for enhancing an endogenous immune response against a cancer. Devices and methods provide therapeutic immunity to subjects against cancer.
    Type: Application
    Filed: April 30, 2015
    Publication date: February 16, 2017
    Inventors: Omar Abdel-Rahman Ali, David J. Mooney, Glenn Dranoff
  • Controlled Delivery of TLR Agonists in Structural Polymeric Devices
    Publication number: 20160296611
    Abstract: The present invention comprises compositions, methods, and devices for creating an stimulating an antigen-specific dendritic cell immune response. Devices and methods provide prophylactic and therapeutic immunity to subjects against cancer and infectious agents.
    Type: Application
    Filed: April 21, 2016
    Publication date: October 13, 2016
    Inventors: Omar Abdel-Rahman Ali, Glenn Dranoff, David J. Mooney
  • Scaffolds For Cell Transplantation
    Publication number: 20160279220
    Abstract: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.
    Type: Application
    Filed: April 21, 2016
    Publication date: September 29, 2016
    Inventors: David J. Mooney, Omar Abdel-Rahman Ali, Eduardo Alexandre Barros E Silva, Hyun Joon Kong, Elliot Earl Hill, JR., Tanyarut Boontheekul
  • Scaffolds For Cell Transplantation
    Publication number: 20160279219
    Abstract: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.
    Type: Application
    Filed: April 21, 2016
    Publication date: September 29, 2016
    Inventors: David J. Mooney, Omar Abdel-Rahman Ali, Eduardo Alexandre Barros E Silva, Hyun Joon Kong, Elliot Earl Hill, JR., Tanyarut Boontheekul
  • SCAFFOLDS FOR CELL TRANSPLANTATION
    Publication number: 20160271298
    Abstract: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.
    Type: Application
    Filed: March 30, 2016
    Publication date: September 22, 2016
    Inventors: David J. Mooney, Omar Abdel-Rahman Ali, Eduardo Alexandre Barros E Silva, Hyun Joon Kong, Elliot Earl Hill, JR., Tanyarut Boontheekul
  • Scaffolds for cell transplantation
    Patent number: 9446107
    Abstract: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: September 20, 2016
    Assignees: President and Fellows of Harvard College, Regents of the University of Michigan
    Inventors: David J. Mooney, Omar Abdel-Rahman Ali, Eduardo Alexandre Barros E Silva, Hyun Joon Kong, Elliot Earl Hill, Jr., Tanyarut Boontheekul
  • Continuous Cell Programming Devices
    Publication number: 20160228543
    Abstract: The present invention comprises compositions, methods, and devices for creating an infection-mimicking environment within a polymer scaffold to stimulate antigen-specific dendritic cell activation. Devices of the present invention are used to provide protective immunity to subjects against infection and cancer.
    Type: Application
    Filed: April 21, 2016
    Publication date: August 11, 2016
    Inventors: David J. Mooney, Omar Abdel-Rahman Ali, Glenn Dranoff
  • Continuous Cell Programming Devices
    Publication number: 20160220668
    Abstract: The present invention comprises compositions, methods, and devices for creating an infection-mimicking environment within a polymer scaffold to stimulate antigen-specific dendritic cell activation. Devices of the present invention are used to provide protective immunity to subjects against infection and cancer.
    Type: Application
    Filed: April 21, 2016
    Publication date: August 4, 2016
    Inventors: David J. Mooney, Omar Abdel-Rahman Ali, Glenn Dranoff
  • CONTINUOUS CELL PROGRAMMING DEVICES
    Publication number: 20160220667
    Abstract: The present invention comprises compositions, methods, and devices for creating an infection-mimicking environment within a polymer scaffold to stimulate antigen-specific dendritic cell activation. Devices of the present invention are used to provide protective immunity to subjects against infection and cancer.
    Type: Application
    Filed: April 21, 2016
    Publication date: August 4, 2016
    Inventors: David J. Mooney, Omar Abdel-Rahman Ali, Glenn Dranoff
  • Controlled delivery of TLR agonists in structural polymeric devices
    Patent number: 9370558
    Abstract: The present invention comprises compositions, methods, and devices for creating an stimulating an antigen-specific dendritic cell immune response. Devices and methods provide prophylactic and therapeutic immunity to subjects against cancer and infectious agents.
    Type: Grant
    Filed: January 14, 2013
    Date of Patent: June 21, 2016
    Assignees: President and Fellows of Harvard College, Dana-Farber Cancer Institute, Inc.
    Inventors: Omar Abdel-Rahman Ali, Glenn Dranoff, David J. Mooney
  • Scaffolds For Cell Transplantation
    Publication number: 20150366956
    Abstract: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.
    Type: Application
    Filed: June 25, 2015
    Publication date: December 24, 2015
    Inventors: David J. Mooney, Omar Abdel-Rahman Ali, Eduardo Alexandre Barros E Silva, Hyun Joon Kong, Elliot Earl Hill, JR., Tanyarut Boontheekul
  • Scaffolds for cell transplantation
    Patent number: 9132210
    Abstract: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.
    Type: Grant
    Filed: March 24, 2014
    Date of Patent: September 15, 2015
    Assignees: President and Fellows of Harvard College, Regents of the University of Michigan
    Inventors: David J. Mooney, Omar Abdel-Rahman Ali, Eduardo Alexandre Barros E Silva, Hyun Joon Kong, Elliot Earl Hill, Jr., Tanyarut Boontheekul
  • Scaffolds For Cell Transplantation
    Publication number: 20150024026
    Abstract: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.
    Type: Application
    Filed: March 24, 2014
    Publication date: January 22, 2015
    Applicants: REGENTS OF THE UNIVERSITY OF MICHIGAN, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: David J. Mooney, Omar Abdel-Rahman Ali, Eduardo Alexandre Barros E Silva, Hyun Joon Kong, Elliot Earl Hill, JR., Tanyarut Boontheekul
  • Scaffolds For Cell Transplantation
    Publication number: 20120134967
    Abstract: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.
    Type: Application
    Filed: November 28, 2011
    Publication date: May 31, 2012
    Inventors: DAVID J. MOONEY, OMAR ABDEL-RAHMAN ALI, EDUARDO ALEXANDRE BARROS E SILVA, HYUN JOON KONG, ELLIOT EARL HILL, JR., TANYARUT BOONTHEEKUL
  • Scaffolds for cell transplantation
    Patent number: 8067237
    Abstract: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.
    Type: Grant
    Filed: December 13, 2006
    Date of Patent: November 29, 2011
    Assignees: President and Fellows of Harvard College, Regents of the University of Michigan
    Inventors: David J. Mooney, Omar Abdel-Rahman Ali, Eduardo Alexandre Barros e Silva, Hyun Joon Kong, Elliott Earl Hill, Jr., Tanyarut Boontheekul
  • SCAFFOLDS FOR CELL COLLECTION OR ELIMINATION
    Publication number: 20110020216
    Abstract: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated therein or thereon, or diffusing from the scaffold composition such that the scaffold composition and/or a bioactive composition captures and eliminates undesirable cells from the body a mammalian subject. The devices mediate active recruitment, sequestration, and removal or elimination of undesirable cells from their host.
    Type: Application
    Filed: June 11, 2008
    Publication date: January 27, 2011
    Inventors: David James Mooney, Omar abdel-Rahman Ali