Patents by Inventor Omar Amirana
Omar Amirana has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230404373Abstract: Systems and methods for imaging tissue using a magnetic catheter are provided. In some embodiments, a catheter is provided that includes a catheter body having a proximal end, a distal end, and one or more lumens therebetween. One or more magnetic bodies are positioned along a length of the catheter body and are responsive to an applied magnetic field. At least one of the one or more magnetic bodies can be located at or near the distal end of the catheter body so that the distal end of the catheter can be manipulated with a magnetic field.Type: ApplicationFiled: June 16, 2023Publication date: December 21, 2023Applicant: 460Medical, Inc.Inventors: Terrance J. Ransbury, Omar Amirana
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Publication number: 20230293000Abstract: Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue comprising: a catheter having a distal end and a proximal end; an inflatable balloon disposed about the distal end of the catheter; and an optical housing extending from the distal end of the catheter into the balloon, the optical housing being configured to position inside the balloon a light source for illuminating a tissue outside the balloon and a camera for imaging the illuminated tissue.Type: ApplicationFiled: January 20, 2023Publication date: September 21, 2023Applicants: 460Medical, Inc.Inventors: Omar Amirana, Kenneth C. Armstrong, Matthew W. Kay, Marco A. Mercader, Terrance J. Ransbury, Narine Sarvazyan
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Patent number: 11596472Abstract: Ablation and visualization systems and methods to access quality of contact between a catheter and tissue are provided. In some embodiments, a method for monitoring tissue ablation of the present disclosure comprises advancing a distal tip of an ablation catheter to a tissue in need of ablation; illuminating the tissue with UV light to excite NADH in the tissue, wherein the tissue is illuminated in a radial direction, an axial direction, or both; determining from a level of NADH fluorescence in the illuminated tissue when the distal tip of the catheter is in contact with the tissue; and delivering ablation energy to the tissue to form a lesion in the tissue.Type: GrantFiled: May 21, 2020Date of Patent: March 7, 2023Assignee: 460Medical, Inc.Inventors: Terrance J. Ransbury, Kenneth C. Armstrong, Omar Amirana, Cinnamon Larson, James Bowen
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Patent number: 11559192Abstract: Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue comprising: a catheter having a distal end and a proximal end; an inflatable balloon disposed about the distal end of the catheter; and an optical housing extending from the distal end of the catheter into the balloon, the optical housing being configured to position inside the balloon a light source for illuminating a tissue outside the balloon and a camera for imaging the illuminated tissue.Type: GrantFiled: May 21, 2020Date of Patent: January 24, 2023Assignees: The George Washington University, 460Medical, Inc.Inventors: Omar Amirana, Kenneth C. Armstrong, Matthew W. Kay, Marco A. Mercader, Terrance J. Ransbury, Narine Sarvazyan
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Patent number: 11559352Abstract: Ablation visualization and monitoring systems and methods are provided. In some embodiments, such methods comprise applying ablation energy to a tissue to form a lesion in the tissue, illuminating the tissue with a light to excite NADH in the tissue, wherein the tissue is illuminated in a radial direction, an axial direction, or both, monitoring a level of NADH fluorescence in the illuminated tissue to determine when the level of NADH fluorescence decreases from a base level in the beginning of the ablating to a predetermined lower level, and stopping ablation of the tissue when the level of NADH fluorescence reaches the predetermined lower level.Type: GrantFiled: May 21, 2020Date of Patent: January 24, 2023Assignees: The George Washington University, 460Medical, Inc.Inventors: Omar Amirana, Kenneth C. Armstrong, James Bowen, Cinnamon Larson, Marco A. Mercader, Terrance J. Ransbury, Narine Sarvazyan
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Publication number: 20220142482Abstract: Systems, catheter and methods for treating Atrial Fibrillation (AF) are provided, which are configure to illuminate a heart tissue having a lesion site; obtain a mitochondrial nicotinamide adenine dinucleotide hydrogen (NADH) fluorescence intensity from the illuminated heart tissue along a first line across the lesion site; create a 2-dimensional (2D) map of the depth of the lesion site along the first line based on the NADH fluorescence intensity; and determine a depth of the lesion site at a selected point along the first line from the 2D map, wherein a lower NADH fluorescence intensity corresponds to a greater depth in the lesion site and a higher NADH fluorescence intensity corresponds to an unablated tissue. The process may be repeated to create a 3 dimensional map of the depth of the lesion.Type: ApplicationFiled: July 29, 2021Publication date: May 12, 2022Inventors: Marco A. Mercader, Narine Sarvazyan, Terrance J. Ransbury, Kenneth C. Armstrong, Omar Amirana
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Publication number: 20220133172Abstract: Systems and methods for ablation optimization are provided. In some embodiments, a catheter system is provided for determining tissue thickness and includes a catheter including a catheter body with a distal tip, source openings in the distal tip for passing light energy to tissue, and detector openings in the distal tip for passing light energy from tissue. A visualization system includes a light source, a light measuring instrument, and optical fibers extending through the catheter body. The optical fibers include source fibers to pass light energy to the tissue through the source openings and detector fibers to detect light energy from the tissue through the detector openings. The source and detector openings are aligned in a longitudinal arrangement along a length of the distal tip and are paired and spaced apart from one another by a separation distance calculated based on a thickness of the tissue to be measured.Type: ApplicationFiled: November 5, 2021Publication date: May 5, 2022Inventors: Terrance J. Ransbury, Omar Amirana
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Publication number: 20220031377Abstract: System and methods for optical tissue interrogation are provided. In some embodiments, a catheter for visualizing ablated tissue is provided, and can include a catheter body, and a distal tip positioned at a distal end of the catheter body. The distal tip can have one or more openings for exchange of light energy between the distal tip of the catheter and tissue.Type: ApplicationFiled: July 28, 2021Publication date: February 3, 2022Inventors: Terrance J. Ransbury, Omar Amirana
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Patent number: 11096584Abstract: Systems, catheter and methods for treating Atrial Fibrillation (AF) are provided, which are configure to illuminate a heart tissue having a lesion site; obtain a mitochondrial nicotinamide adenine dinucleotide hydrogen (NADH) fluorescence intensity from the illuminated heart tissue along a first line across the lesion site; create a 2-dimensional (2D) map of the depth of the lesion site along the first line based on the NADH fluorescence intensity; and determine a depth of the lesion site at a selected point along the first line from the 2D map, wherein a lower NADH fluorescence intensity corresponds to a greater depth in the lesion site and a higher NADH fluorescence intensity corresponds to an unablated tissue. The process may be repeated to create a 3 dimensional map of the depth of the lesion.Type: GrantFiled: November 14, 2014Date of Patent: August 24, 2021Assignees: The George Washington University, 460Medical, Inc.Inventors: Marco A. Mercader, Narine Sarvazyan, Terrance J. Ransbury, Kenneth C. Armstrong, Omar Amirana
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Publication number: 20210205017Abstract: In some embodiments, a system for optical tissue interrogation comprises a catheter having a plurality of electrodes disposed in an array at a distal end of the catheter, the plurality of electrodes being configured to deliver ablation energy to tissue; and one or more optical fibers extending through the catheter to deliver light from a light source to the tissue and to deliver optical information comprising nicotinamide adenine dinucleotide hydrogen (NADH) fluorescence from the tissue to a sensor, wherein each electrode of the plurality of electrodes is associated with at least one of the one or more optical fibers.Type: ApplicationFiled: January 8, 2021Publication date: July 8, 2021Inventors: Omar Amirana, Terrance J. Ransbury, Arun Jaganathan
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Publication number: 20210045834Abstract: Catheter for visualizing ablated tissue comprises a catheter body; a distal tip positioned at a distal end of the catheter body, the distal tip defining a illumination cavity, the distal tip having one or more openings for exchange of light energy between the illumination cavity and tissue; a light directing member disposed within the illumination cavity, the light directing member being configured to split light energy received from a light source into multiple beams and to such beams to the tissue through the corresponding more openings in the distal tip.Type: ApplicationFiled: July 30, 2020Publication date: February 18, 2021Inventors: Terrance J. Ransbury, Kenneth C. Armstrong, Omar Amirana, Cinnamon Larson
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Publication number: 20210015365Abstract: Optical sensors, systems, and methods are described, which may be used to provide or analyze information about a subject. The optical sensor may be placed in proximity to the subject and may include optical sources and optical detectors. The optical sources may irradiate the subject with optical signals and the optical detectors can detect signals from the subject. Analysis of the detected signals can yield information about the subject.Type: ApplicationFiled: May 5, 2020Publication date: January 21, 2021Applicant: Invisio Medical, Inc.Inventors: Thomas Muehlemann, Catherine Pace, Karim Haroud, Stefan Troller, Azadeh Khanicheh, Michel Bruehwiler, Jeffery J. Caputo, Russell L. Herrig, Omar Amirana, Joseph Culver, John Shambroom
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Patent number: 10867720Abstract: Composite materials are made by impregnating a non-conductive material with a conducting monomer to form a monomer-impregnated non-conductive material, and polymerizing the monomer-impregnated non-conductive material to form the composite material. The composite materials are used in medical devices and implants.Type: GrantFiled: September 24, 2018Date of Patent: December 15, 2020Assignee: Heraeus Medical Components LLCInventors: Kyle Mallires, Jeffrey L. Hendricks, Sarah Richardson-Burns, Omar Amirana
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Publication number: 20200352425Abstract: Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue comprising: a catheter having a distal end and a proximal end; an inflatable balloon disposed about the distal end of the catheter; and an optical housing extending from the distal end of the catheter into the balloon, the optical housing being configured to position inside the balloon a light source for illuminating a tissue outside the balloon and a camera for imaging the illuminated tissue.Type: ApplicationFiled: May 21, 2020Publication date: November 12, 2020Inventors: Omar Amirana, Kenneth C. Armstrong, Matthew W. Kay, Marco A. Mercader, Terrance J. Ransbury, Narine Sarvazyan
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Publication number: 20200352645Abstract: Ablation visualization and monitoring systems and methods are provided. In some embodiments, such methods comprise applying ablation energy to a tissue to form a lesion in the tissue, illuminating the tissue with a light to excite NADH in the tissue, wherein the tissue is illuminated in a radial direction, an axial direction, or both, monitoring a level of NADH fluorescence in the illuminated tissue to determine when the level of NADH fluorescence decreases from a base level in the beginning of the ablating to a predetermined lower level, and stopping ablation of the tissue when the level of NADH fluorescence reaches the predetermined lower level.Type: ApplicationFiled: May 21, 2020Publication date: November 12, 2020Inventors: Omar Amirana, Kenneth C. Armstrong, James Bowen, Cinnamon Larson, Marco A. Mercader, Terrance J. Ransbury, Narine Sarvazyan
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Publication number: 20200352644Abstract: Ablation and visualization systems and methods to access quality of contact between a catheter and tissue are provided. In some embodiments, a method for monitoring tissue ablation of the present disclosure comprises advancing a distal tip of an ablation catheter to a tissue in need of ablation; illuminating the tissue with UV light to excite NADH in the tissue, wherein the tissue is illuminated in a radial direction, an axial direction, or both; determining from a level of NADH fluorescence in the illuminated tissue when the distal tip of the catheter is in contact with the tissue; and delivering ablation energy to the tissue to form a lesion in the tissue.Type: ApplicationFiled: May 21, 2020Publication date: November 12, 2020Inventors: Terrance J. Ransbury, Kenneth C. Armstrong, Omar Amirana, Cinnamon Larson, James Bowen
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Patent number: 10779904Abstract: Catheter for visualizing ablated tissue comprises a catheter body; a distal tip positioned at a distal end of the catheter body, the distal tip defining a illumination cavity, the distal tip having one or more openings for exchange of light energy between the illumination cavity and tissue; a light directing member disposed within the illumination cavity, the light directing member being configured to split light energy received from a light source into multiple beams and to such beams to the tissue through the corresponding more openings in the distal tip.Type: GrantFiled: October 21, 2015Date of Patent: September 22, 2020Assignee: 460Medical, Inc.Inventors: Terrance J. Ransbury, Kenneth C. Armstrong, Omar Amirana, Cinnamon Larson
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Patent number: 10722301Abstract: Ablation visualization and monitoring systems and methods are provided. In some embodiments, such methods comprise applying ablation energy to a tissue to form a lesion in the tissue, illuminating the tissue with a light to excite NADH in the tissue, wherein the tissue is illuminated in a radial direction, an axial direction, or both, monitoring a level of NADH fluorescence in the illuminated tissue to determine when the level of NADH fluorescence decreases from a base level in the beginning of the ablating to a predetermined lower level, and stopping ablation of the tissue when the level of NADH fluorescence reaches the predetermined lower level.Type: GrantFiled: November 3, 2015Date of Patent: July 28, 2020Assignees: The George Washington University, 460Medical, Inc.Inventors: Omar Amirana, Kenneth C. Armstrong, James Bowen, Cinnamon Larson, Marco A. Mercader, Terrance J. Ransbury, Narine Sarvazyan
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Patent number: 10716462Abstract: Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue comprising: a catheter having a distal end and a proximal end; an inflatable balloon disposed about the distal end of the catheter; and an optical housing extending from the distal end of the catheter into the balloon, the optical housing being configured to position inside the balloon a light source for illuminating a tissue outside the balloon and a camera for imaging the illuminated tissue.Type: GrantFiled: May 23, 2018Date of Patent: July 21, 2020Assignees: The George Washington University, 460Medical, Inc.Inventors: Omar Amirana, Kenneth C. Armstrong, Matthew W. Kay, Marco A. Mercader, Terrance J. Ransbury, Narine Sarvazyan
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Patent number: 10682179Abstract: Ablation and visualization systems and methods to access quality of contact between a catheter and tissue are provided. In some embodiments, a method for monitoring tissue ablation of the present disclosure comprises advancing a distal tip of an ablation catheter to a tissue in need of ablation; illuminating the tissue with UV light to excite NADH in the tissue, wherein the tissue is illuminated in a radial direction, an axial direction, or both; determining from a level of NADH fluorescence in the illuminated tissue when the distal tip of the catheter is in contact with the tissue; and delivering ablation energy to the tissue to form a lesion in the tissue.Type: GrantFiled: October 23, 2018Date of Patent: June 16, 2020Assignee: 460Medical, Inc.Inventors: Terrance J. Ransbury, Kenneth C. Armstrong, Omar Amirana, Cinnamon Larson, James Bowen